adisease

Showing entry for Thyroid Diseases

General Disease Information
BXGD Id	BXGD002844
Disease Name	Thyroid Diseases
Disease CUI Id	C0040128
MeSH Codes	C19
Disease Class Name	Endocrine System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000818
Human Phenotype Ontology Term	Abnormality of the endocrine system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15119	BXGT004128	T-box transcription factor TBX3	6926	reviewed	Transcription factor
O15178	BXGT004135	T-box transcription factor T	6862	reviewed	Transcription factor
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60462	BXGT004876	Neuropilin-2	8828	reviewed
O95256	BXGT005364	Interleukin-18 receptor accessory protein	8807	reviewed	Receptor
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02765	BXGT005952	Alpha-2-HS-glycoprotein	197	reviewed	Enzyme modulator
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04731	BXGT006251	Metallothionein-1A	4489	reviewed
P04732	BXGT006252	Metallothionein-1E	4493	reviewed
P04733	BXGT006253	Metallothionein-1F	4494	reviewed
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07438	BXGT006625	Metallothionein-1B	4490	reviewed
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P09382	BXGT006882	Galectin-1	3956	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P09923	BXGT006942	Intestinal-type alkaline phosphatase	248	reviewed	Enzyme
P10323	BXGT007557	Acrosin	49	reviewed	Enzyme
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10646	BXGT007598	Tissue factor pathway inhibitor	7035	reviewed	Enzyme modulator
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10827	BXGT007623	Thyroid hormone receptor alpha	7067	reviewed	Nuclear receptor
P10997	BXGT007643	Islet amyloid polypeptide	3375	reviewed	Signaling
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13640	BXGT007935	Metallothionein-1G	4495	reviewed
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23945	BXGT008931	Follicle-stimulating hormone receptor	2492	reviewed	G-protein coupled receptor
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P28702	BXGT009287	Retinoic acid receptor RXR-beta	6257	reviewed	Nuclear receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P30874	BXGT009475	Somatostatin receptor type 2	6752	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P36021	BXGT009893	Monocarboxylate transporter 8	6567	reviewed	Transporter
P36969	BXGT009949	Phospholipid hydroperoxide glutathione peroxidase	2879	reviewed	Enzyme
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48039	BXGT010607	Melatonin receptor type 1A	4543	reviewed	G-protein coupled receptor
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P51684	BXGT010880	C-C chemokine receptor type 6	1235	reviewed	G-protein coupled receptor
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P56937	BXGT011205	3-keto-steroid reductase	51478	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P80294	BXGT011890	Metallothionein-1H	4496	reviewed
P80297	BXGT011891	Metallothionein-1X	4501	reviewed
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
Q02363	BXGT012650	DNA-binding protein inhibitor ID-2	3398	reviewed	Transcription factor
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q06710	BXGT012887	Paired box protein Pax-8	7849	reviewed
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q08499	BXGT012988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	5144	reviewed
Q08722	BXGT013002	Leukocyte surface antigen CD47	961	reviewed
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q14392	BXGT013465	Transforming growth factor beta activator LRRC32	2615	reviewed	Receptor
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q6VVX0	BXGT016585	Vitamin D 25-hydroxylase	120227	reviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8N339	BXGT018503	Metallothionein-1M	4499	reviewed
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q9BQE4	BXGT020110	Selenoprotein S	55829	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9H2X6	BXGT020458	Homeodomain-interacting protein kinase 2	28996	reviewed	Kinase
Q9NNW7	BXGT021139	Thioredoxin reductase 2, mitochondrial	10587	reviewed	Enzyme
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UPY3	BXGT021802	Endoribonuclease Dicer	23405	reviewed	Enzyme
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
P31358	BXGT025061	CAMPATH-1 antigen	1043	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
Q9NRR4	BXGT025788	Ribonuclease 3	29102	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}