Showing entry for Neural Tube Defects


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002036
Disease NameNeural Tube Defects
Disease CUI IdC0027794
MeSH Codes C16   C10  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Semantic TypeCongenital Abnormality
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A4D126 BXGT001208 D-ribitol-5-phosphate cytidylyltransferase 729920 reviewed
O14641 BXGT004078 Segment polarity protein dishevelled homolog DVL-2 1856 reviewed Signaling
O14717 BXGT004083 tRNA (cytosine(38)-C(5))-methyltransferase 1787 reviewed
O14727 BXGT004084 Apoptotic protease-activating factor 1 317 reviewed
O15178 BXGT004135 T-box transcription factor T 6862 reviewed Transcription factor
O15353 BXGT004155 Forkhead box protein N1 8456 reviewed
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O43293 BXGT004584 Death-associated protein kinase 3 1613 reviewed Kinase
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60494 BXGT004879 Cubilin 8029 reviewed
O75530 BXGT005135 Polycomb protein EED 8726 reviewed
O75581 BXGT005136 Low-density lipoprotein receptor-related protein 6 4040 reviewed
O94788 BXGT005333 Retinal dehydrogenase 2 8854 reviewed Enzyme
P00374 BXGT005520 Dihydrofolate reductase 1719 reviewed Enzyme
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01031 BXGT005720 Complement C5 727 reviewed Enzyme modulator
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P02775 BXGT005960 Platelet basic protein 5473 reviewed Signaling
P04264 BXGT006176 Keratin, type II cytoskeletal 1 3848 reviewed
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05177 BXGT006336 Cytochrome P450 1A2 1544 reviewed Enzyme
P05556 BXGT006368 Integrin beta-1 3688 reviewed Receptor
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P06276 BXGT006430 Cholinesterase 590 reviewed
P08758 BXGT006821 Annexin A5 308 reviewed
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P0DPH7 BXGT007527 Tubulin alpha-3C chain 7278 reviewed
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10599 BXGT007583 Thioredoxin 7295 reviewed
P10600 BXGT007584 Transforming growth factor beta-3 proprotein 7043 reviewed Signaling
P11168 BXGT007663 Solute carrier family 2, facilitated glucose transporter member 2 6514 reviewed Transporter
P11586 BXGT007723 C-1-tetrahydrofolate synthase, cytoplasmic 4522 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P13497 BXGT007915 Bone morphogenetic protein 1 649 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14207 BXGT007993 Folate receptor beta 2350 reviewed
P15328 BXGT008108 Folate receptor alpha 2348 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P17252 BXGT008294 Protein kinase C alpha type 5578 reviewed Kinase
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha 5566 reviewed Kinase
P18206 BXGT008389 Vinculin 7414 reviewed
P18440 BXGT008404 Arylamine N-acetyltransferase 1 9 reviewed Enzyme
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P20061 BXGT008542 Transcobalamin-1 6947 reviewed
P20062 BXGT008543 Transcobalamin-2 6948 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21730 BXGT008687 C5a anaphylatoxin chemotactic receptor 1 728 reviewed G-protein coupled receptor
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22033 BXGT008721 Methylmalonyl-CoA mutase, mitochondrial 4594 reviewed Enzyme
P22694 BXGT008797 cAMP-dependent protein kinase catalytic subunit beta 5567 reviewed Kinase
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P23378 BXGT008859 Glycine dehydrogenase (decarboxylating), mitochondrial 2731 reviewed Enzyme
P23921 BXGT008927 Ribonucleoside-diphosphate reductase large subunit 6240 reviewed Enzyme
P25929 BXGT009078 Neuropeptide Y receptor type 1 4886 reviewed G-protein coupled receptor
P27352 BXGT009174 Cobalamin binding intrinsic factor 2694 reviewed
P29373 BXGT009337 Cellular retinoic acid-binding protein 2 1382 reviewed
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30307 BXGT009421 M-phase inducer phosphatase 3 995 reviewed Enzyme
P30793 BXGT009466 GTP cyclohydrolase 1 2643 reviewed Enzyme
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase 208 reviewed Kinase
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P34896 BXGT009767 Serine hydroxymethyltransferase, cytosolic 6470 reviewed Enzyme
P35221 BXGT009798 Catenin alpha-1 1495 reviewed Cellular structure
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P37802 BXGT010013 Transgelin-2 8407 reviewed Cellular structure
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P41440 BXGT010261 Folate transporter 1 6573 reviewed Transporter
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42702 BXGT010335 Leukemia inhibitory factor receptor 3977 reviewed Signaling
P42785 BXGT010338 Lysosomal Pro-X carboxypeptidase 5547 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P48506 BXGT010635 Glutamate--cysteine ligase catalytic subunit 2729 reviewed Enzyme
P48728 BXGT010654 Aminomethyltransferase, mitochondrial 275 reviewed
P49327 BXGT010694 Fatty acid synthase 2194 reviewed Enzyme
P49916 BXGT010764 DNA ligase 3 3980 reviewed Enzyme
P50225 BXGT010781 Sulfotransferase 1A1 6817 reviewed
P51787 BXGT010889 Potassium voltage-gated channel subfamily KQT member 1 3784 reviewed Ion channel
P54764 BXGT011078 Ephrin type-A receptor 4 2043 reviewed Kinase
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P62805 BXGT011457 Histone H4 8370 reviewed
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P68366 BXGT011595 Tubulin alpha-4A chain 7277 reviewed Cellular structure
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q01831 BXGT012621 DNA repair protein complementing XP-C cells 7508 reviewed Nucleic acid binding
Q02363 BXGT012650 DNA-binding protein inhibitor ID-2 3398 reviewed Transcription factor
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q04609 BXGT012768 Glutamate carboxypeptidase 2 2346 reviewed Enzyme
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13394 BXGT013347 Putative nucleotidyltransferase MAB21L1 4081 reviewed
Q13427 BXGT013354 Peptidyl-prolyl cis-trans isomerase G 9360 reviewed
Q13796 BXGT013395 Protein Shroom2 357 reviewed
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 9817 reviewed
Q14160 BXGT013450 Protein scribble homolog 23513 reviewed
Q14397 BXGT013467 Glucokinase regulatory protein 2646 reviewed
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15465 BXGT013573 Sonic hedgehog protein 6469 reviewed
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle 4638 reviewed Kinase
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16651 BXGT013649 Prostasin 5652 reviewed Enzyme
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16678 BXGT013656 Cytochrome P450 1B1 1545 reviewed Enzyme
Q16739 BXGT013663 Ceramide glucosyltransferase 7357 reviewed Enzyme
Q86VW1 BXGT017621 Solute carrier family 22 member 16 85413 reviewed Transporter
Q86X55 BXGT017627 Histone-arginine methyltransferase CARM1 10498 reviewed Epigenetic regulator
Q8NBP7 BXGT018541 Proprotein convertase subtilisin/kexin type 9 255738 reviewed Enzyme
Q92979 BXGT019402 Ribosomal RNA small subunit methyltransferase NEP1 10436 reviewed Nucleic acid binding
Q93088 BXGT019458 Betaine--homocysteine S-methyltransferase 1 635 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q99683 BXGT019947 Mitogen-activated protein kinase kinase kinase 5 4217 reviewed Kinase
Q99707 BXGT019952 Methionine synthase 4548 reviewed
Q99757 BXGT019959 Thioredoxin, mitochondrial 25828 reviewed Enzyme
Q9BUZ4 BXGT020139 TNF receptor-associated factor 4 9618 reviewed Signaling
Q9BX84 BXGT020161 Transient receptor potential cation channel subfamily M member 6 140803 reviewed Kinase
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO 79068 reviewed
Q9H251 BXGT020449 Cadherin-23 64072 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9NPF0 BXGT021153 CD320 antigen 51293 reviewed
Q9NRR6 BXGT021193 Phosphatidylinositol polyphosphate 5-phosphatase type IV 56623 reviewed
Q9UBK8 BXGT021655 Methionine synthase reductase 4552 reviewed
Q9UMX1 BXGT021778 Suppressor of fused homolog 51684 reviewed
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
O60936 BXGT022857 Nucleolar protein 3 8996 reviewed
Q92922 BXGT023066 SWI/SNF complex subunit SMARCC1 6599 reviewed Enzyme
Q8TBZ3 BXGT023141 WD repeat-containing protein 20 91833 reviewed
Q15583 BXGT024027 Homeobox protein TGIF1 7050 reviewed Enzyme
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
P35251 BXGT025853 Replication factor C subunit 1 5981 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease