Showing entry for UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004147
Protein NameUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Uniport IdO15294
GeneOGT
Gene Id8473
DomainGlyco_transf_41; TPR_1; TPR_11; TPR_12; TPR_16; TPR_8
Pfam PF13844   PF00515   PF13181  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00514 Other types of O-glycan biosynthesis
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0080182 histone H3-K4 trimethylation
Biological Process GO:0043984 histone H4-K16 acetylation
Biological Process GO:0043981 histone H4-K5 acetylation
Biological Process GO:0043982 histone H4-K8 acetylation
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0031397 negative regulation of protein ubiquitination
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0061087 positive regulation of histone H3-K27 methylation
Biological Process GO:0045862 positive regulation of proteolysis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006493 protein O-linked glycosylation
Biological Process GO:0016485 protein processing
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0006110 regulation of glycolytic process
Biological Process GO:0046626 regulation of insulin receptor signaling pathway
Biological Process GO:0035020 regulation of Rac protein signal transduction
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0032868 response to insulin
Biological Process GO:0007584 response to nutrient
Biological Process GO:0007165 signal transduction
Biological Process GO:0016032 viral process
molecular function GO:0008375 acetylglucosaminyltransferase activity
molecular function GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
molecular function GO:0016262 protein N-acetylglucosaminyltransferase activity
molecular function GO:0097363 protein O-GlcNAc transferase activity
cellular component GO:0042995 cell projection
cellular component GO:0005829 cytosol
cellular component GO:0000123 histone acetyltransferase complex
cellular component GO:0031966 mitochondrial membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
cellular component GO:0017122 protein N-acetylglucosaminyltransferase complex
Reactome
Pathway Id Pathway Name
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-392499 Metabolism of proteins
R-HSA-4839726 Chromatin organization
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218859 Regulated Necrosis
R-HSA-5357801 Programmed Cell Death
R-HSA-5675482 Regulation of necroptotic cell death
R-HSA-5688426 Deubiquitination
R-HSA-5689603 UCH proteinases
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007107 BXGD000428 Malignant neoplasm of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027070 BXGD001967 Myoepithelioma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0240379 BXGD005033 Open mouth (finding)
C0241355 BXGD005092 Small testicle
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0342283 BXGD007453 Hyperproinsulinemia Nutritional and Metabolic Diseases; Endocrine System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0595989 BXGD009632 Carcinoma of larynx Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0949664 BXGD011583 Tauopathies Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1845977 BXGD014769 X- linked recessive
C1855925 BXGD015561 Hyperopia, High Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4478379 BXGD022923 MENTAL RETARDATION, X-LINKED 106
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002591 Potassium 39.1
BXGC0003193 Aldehydes 30.03
BXGC0003993 Uridine diphosphate 404.16
BXGC0005000 2-Benzoxazolone 135.12
BXGC0040682 2-Hydroxyquinoline-4-carboxylic acid 189.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein