adisease

Showing entry for Hypospadias

General Disease Information
BXGD Id	BXGD010882
Disease Name	Hypospadias
Disease CUI Id	C0848558
MeSH Codes	C16 C13 C12
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Semantic Type	Congenital Abnormality
Human Phenotype Ontology Id	HP:0000119
Human Phenotype Ontology Term	Abnormality of the genitourinary system
Disease Ontology Id	DOID:0080015
Disease Ontology Class Name	physical disorder
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00755	BXGT003945	Protein Wnt-7a	7476	reviewed	Signaling
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	2563	reviewed	Ion channel
O15230	BXGT004138	Laminin subunit alpha-5	3911	reviewed	Enzyme modulator
O15294	BXGT004147	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	8473	reviewed
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O43854	BXGT004630	EGF-like repeat and discoidin I-like domain-containing protein 3	10085	reviewed	Enzyme
O43929	BXGT004638	Origin recognition complex subunit 4	5000	reviewed	Nucleic acid binding
O60566	BXGT004884	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	701	reviewed	Kinase
O75147	BXGT005102	Obscurin-like protein 1	23363	reviewed
O75496	BXGT005132	Geminin	51053	reviewed
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
O94811	BXGT005336	Tubulin polymerization-promoting protein	11076	reviewed	Cellular structure
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O96028	BXGT005417	Histone-lysine N-methyltransferase NSD2	7468	reviewed	Epigenetic regulator
P00167	BXGT005473	Cytochrome b5	1528	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P02461	BXGT005880	Collagen alpha-1(III) chain	1281	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05108	BXGT006317	Cholesterol side-chain cleavage enzyme, mitochondrial	1583	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P07437	BXGT006624	Tubulin beta chain	203068	reviewed	Cellular structure
P07510	BXGT006631	Acetylcholine receptor subunit gamma	1146	reviewed	Ion channel
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08686	BXGT006813	Steroid 21-hydroxylase	1589	reviewed
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12273	BXGT007787	Prolactin-inducible protein	5304	reviewed
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P16070	BXGT008186	CD44 antigen	960	reviewed
P16234	BXGT008209	Platelet-derived growth factor receptor alpha	5156	reviewed	Kinase
P16435	BXGT008226	NADPH--cytochrome P450 reductase	5447	reviewed
P18075	BXGT008375	Bone morphogenetic protein 7	655	reviewed	Signaling
P18405	BXGT008400	3-oxo-5-alpha-steroid 4-dehydrogenase 1	6715	reviewed	Enzyme
P18847	BXGT008431	Cyclic AMP-dependent transcription factor ATF-3	467	reviewed	Transcription factor
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21333	BXGT008638	Filamin-A	2316	reviewed
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22314	BXGT008755	Ubiquitin-like modifier-activating enzyme 1	7317	reviewed	Enzyme
P27635	BXGT009194	60S ribosomal protein L10	6134	reviewed	Nucleic acid binding
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31213	BXGT009515	3-oxo-5-alpha-steroid 4-dehydrogenase 2	6716	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37058	BXGT009956	Testosterone 17-beta-dehydrogenase 3	3293	reviewed
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41227	BXGT010238	N-alpha-acetyltransferase 10	8260	reviewed	Enzyme
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P45984	BXGT010495	Mitogen-activated protein kinase 9	5601	reviewed	Kinase
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P50542	BXGT010808	Peroxisomal targeting signal 1 receptor	5830	reviewed	Transporter
P51843	BXGT010897	Nuclear receptor subfamily 0 group B member 1	190	reviewed	Nuclear receptor
P52788	BXGT010953	Spermine synthase	6611	reviewed
P52799	BXGT010956	Ephrin-B2	1948	reviewed	Signaling
P55263	BXGT011115	Adenosine kinase	132	reviewed	Kinase
P56937	BXGT011205	3-keto-steroid reductase	51478	reviewed
P57772	BXGT011220	Selenocysteine-specific elongation factor	60678	reviewed	Enzyme
P60953	BXGT011342	Cell division control protein 42 homolog	998	reviewed	Enzyme modulator
P61224	BXGT011370	Ras-related protein Rap-1b	5908	reviewed	Enzyme modulator
P62834	BXGT011464	Ras-related protein Rap-1A	5906	reviewed	Enzyme modulator
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P68133	BXGT011578	Actin, alpha skeletal muscle	58	reviewed	Cellular structure
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P78330	BXGT011833	Phosphoserine phosphatase	5723	reviewed	Enzyme
Q02790	BXGT012672	Peptidyl-prolyl cis-trans isomerase FKBP4	2288	reviewed	Enzyme
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q08499	BXGT012988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	5144	reviewed
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q13233	BXGT013330	Mitogen-activated protein kinase kinase kinase 1	4214	reviewed	Kinase
Q13285	BXGT013335	Steroidogenic factor 1	2516	reviewed	Nuclear receptor
Q13303	BXGT013336	Voltage-gated potassium channel subunit beta-2	8514	reviewed	Ion channel
Q13363	BXGT013344	C-terminal-binding protein 1	1487	reviewed	Transcription factor
Q13415	BXGT013350	Origin recognition complex subunit 1	4998	reviewed	Nucleic acid binding
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q14289	BXGT013459	Protein-tyrosine kinase 2-beta	2185	reviewed	Kinase
Q14332	BXGT013462	Frizzled-2	2535	reviewed	G-protein coupled receptor
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q15465	BXGT013573	Sonic hedgehog protein	6469	reviewed
Q15637	BXGT013586	Splicing factor 1	7536	reviewed	Nucleic acid binding
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q16874	BXGT013685	Cytochrome P450 21-hydroxylase	1589	unreviewed
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q2MKA7	BXGT014140	R-spondin-1	284654	reviewed
Q6PCD5	BXGT016464	E3 ubiquitin-protein ligase RFWD3	55159	reviewed	Enzyme
Q6UWP2	BXGT016567	Dehydrogenase/reductase SDR family member 11	79154	reviewed	Enzyme
Q86VP1	BXGT017619	Tax1-binding protein 1	8887	reviewed
Q86YC2	BXGT017633	Partner and localizer of BRCA2	79728	reviewed
Q8IYD8	BXGT018367	Fanconi anemia group M protein	57697	reviewed	Enzyme
Q8NCC3	BXGT018546	Group XV phospholipase A2	23659	reviewed	Enzyme
Q8NFD5	BXGT018560	AT-rich interactive domain-containing protein 1B	57492	reviewed
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q96QV1	BXGT019722	Hedgehog-interacting protein	64399	reviewed
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9NPD8	BXGT021152	Ubiquitin-conjugating enzyme E2 T	29089	reviewed
Q9NPI8	BXGT021161	Fanconi anemia group F protein	2188	reviewed
Q9NW38	BXGT021230	E3 ubiquitin-protein ligase FANCL	55120	reviewed	Enzyme
Q9NX14	BXGT021242	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	54539	reviewed	Enzyme
Q9NZJ5	BXGT021275	Eukaryotic translation initiation factor 2-alpha kinase 3	9451	reviewed	Kinase
Q9UBM7	BXGT021657	7-dehydrocholesterol reductase	1717	reviewed	Enzyme
Q9UGL1	BXGT021685	Lysine-specific demethylase 5B	10765	reviewed	Epigenetic regulator
Q9UI95	BXGT021714	Mitotic spindle assembly checkpoint protein MAD2B	10459	reviewed
Q9UJ71	BXGT021725	C-type lectin domain family 4 member K	50489	reviewed	Receptor
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9UPZ9	BXGT021804	Serine/threonine-protein kinase ICK	22858	reviewed	Kinase
Q5KSL6	BXGT022671	Diacylglycerol kinase kappa	139189	reviewed	Enzyme
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
Q96L73	BXGT024676	Histone-lysine N-methyltransferase, H3 lysine-36 specific	64324	reviewed	Epigenetic regulator
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}