Showing entry for Cytoplasmic protein NCK2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004608
Protein NameCytoplasmic protein NCK2
Uniport IdO43639
GeneNCK2
Gene Id8440
DomainSH2; SH3_1; SH3_9
Pfam PF00017   PF00018   PF14604  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04012 ErbB signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05130 Pathogenic Escherichia coli infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0016477 cell migration
Biological Process GO:0060996 dendritic spine development
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0007173 epidermal growth factor receptor signaling pathway
Biological Process GO:0001771 immunological synapse formation
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
Biological Process GO:0033137 negative regulation of peptidyl-serine phosphorylation
Biological Process GO:1903898 negative regulation of PERK-mediated unfolded protein response
Biological Process GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
Biological Process GO:0007176 regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0007172 signal complex assembly
Biological Process GO:0007165 signal transduction
Biological Process GO:0042110 T cell activation
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0008093 cytoskeletal anchor activity
molecular function GO:0001784 phosphotyrosine residue binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0097110 scaffold protein binding
molecular function GO:0035591 signaling adaptor activity
molecular function GO:0030159 signaling receptor complex adaptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0014069 postsynaptic density
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1500931 Cell-Cell communication
R-HSA-162582 Signal Transduction
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-194138 Signaling by VEGF
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373753 Nephrin family interactions
R-HSA-376176 Signaling by ROBO receptors
R-HSA-3928664 Ephrin signaling
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-428540 Activation of RAC1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-8985801 Regulation of cortical dendrite branching
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001925 BXGD000090 Albuminuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028326 BXGD002075 Noonan Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0152136 BXGD003548 Low Tension Glaucoma Eye Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0236969 BXGD004842 Substance-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
C3887942 BXGD019931 GLAUCOMA 1, OPEN ANGLE, B
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004266 2-Propanol 60.1
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein