Showing entry for GDP-mannose 4,6 dehydratase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004881
Protein NameGDP-mannose 4,6 dehydratase
Uniport IdO60547
GeneGMDS
Gene Id2762
DomainGDP_Man_Dehyd
Pfam PF16363  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042351 'de novo' GDP-L-fucose biosynthetic process
Biological Process GO:0019673 GDP-mannose metabolic process
Biological Process GO:0007219 Notch signaling pathway
molecular function GO:0008446 GDP-mannose 4,6-dehydratase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0070401 NADP+ binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-392499 Metabolism of proteins
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-597592 Post-translational protein modification
R-HSA-6787639 GDP-fucose biosynthesis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017612 BXGD001129 Glaucoma, Open-Angle Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018935 BXGD001252 Hematocrit procedure
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0040420 BXGD002861 Tonometry
C0042834 BXGD003004 Vital capacity
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202239 BXGD004087 Uric acid measurement (procedure)
C0271217 BXGD006176 Impairment level: total impairment of both eyes (disorder) Eye Diseases
C0302362 BXGD006845 Brucella melitensis infection Infections
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0518015 BXGD009068 Hemoglobin measurement
C0557874 BXGD009444 Global developmental delay
C0563625 BXGD009484 Agnosia for Pain Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1879328 BXGD016573 Blindness both eyes NOS (disorder) Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0006198 Citric acid 192.12
BXGC0012750 Guanosine Diphosphate Fucose 589.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein