Showing entry for Ribonuclease H1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004910
Protein NameRibonuclease H1
Uniport IdO60930
GeneRNASEH1
Gene Id246243
DomainCauli_VI; RNase_H
Pfam PF01693   PF00075  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03030 DNA replication
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043137 DNA replication, removal of RNA primer
Biological Process GO:0006401 RNA catabolic process
Biological Process GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
molecular function GO:0000287 magnesium ion binding
molecular function GO:0003676 nucleic acid binding
molecular function GO:0004540 ribonuclease activity
molecular function GO:0003723 RNA binding
molecular function GO:0004523 RNA-DNA hybrid ribonuclease activity
cellular component GO:0005737 cytoplasm
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0162292 BXGD003930 External Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0162666 BXGD003967 Mitochondrial Encephalomyopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0162674 BXGD003973 Chronic progressive external ophthalmoplegia Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0265289 BXGD005502 Metaphyseal chondrodysplasia Schmid type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0424551 BXGD008533 Impaired exercise tolerance
C0427055 BXGD008601 Facial Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0587246 BXGD009616 Muscle weakness of limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1836150 BXGD014082 Gait imbalance
C1836440 BXGD014115 Increased serum lactate Nutritional and Metabolic Diseases
C1836842 BXGD014167 Psychomotor deterioration Mental Disorders
C1843637 BXGD014597 Neck flexor weakness
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1847609 BXGD014877 Deficit in phonologic short-term memory Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C1849097 BXGD015006 Loss of ability to walk
C1850830 BXGD015181 Exercise-induced myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1854489 BXGD015408 Limb dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1856694 BXGD015632 Areflexia of lower limbs Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865916 BXGD016355 Bilateral ptosis Eye Diseases
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4025244 BXGD021603 Abnormal atrioventricular conduction
C4025647 BXGD021708 Abnormality of the spinocerebellar tracts
C4225312 BXGD022219 PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MITOCHONDRIAL DNA DELETIONS, AUTOSOMAL RECESSIVE 2
C4511138 BXGD022996 Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein