adisease

Showing entry for Dysarthria

General Disease Information
BXGD Id	BXGD000817
Disease Name	Dysarthria
Disease CUI Id	C0013362
MeSH Codes	C23 C10
Disease Class Name	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00142	BXGT003883	Thymidine kinase 2, mitochondrial	7084	reviewed	Kinase
O00217	BXGT003898	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	4728	reviewed	Enzyme
O00305	BXGT003907	Voltage-dependent L-type calcium channel subunit beta-4	785	reviewed	Ion channel
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O00483	BXGT003930	Cytochrome c oxidase subunit NDUFA4	4697	reviewed	Enzyme
O00555	BXGT003936	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	773	reviewed	Ion channel
O00754	BXGT003944	Lysosomal alpha-mannosidase	4125	reviewed
O14656	BXGT004080	Torsin-1A	1861	reviewed	Chaperone
O14773	BXGT004096	Tripeptidyl-peptidase 1	1200	reviewed	Enzyme
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O15305	BXGT004152	Phosphomannomutase 2	5373	reviewed	Enzyme
O15409	BXGT004166	Forkhead box protein P2	93986	reviewed
O43181	BXGT004576	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	4724	reviewed
O43424	BXGT004592	Glutamate receptor ionotropic, delta-2	2895	reviewed	Ion channel
O43497	BXGT004596	Voltage-dependent T-type calcium channel subunit alpha-1G	8913	reviewed	Ion channel
O43678	BXGT004613	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	4695	reviewed	Enzyme
O43896	BXGT004632	Kinesin-like protein KIF1C	10749	reviewed	Cellular structure
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O60930	BXGT004910	Ribonuclease H1	246243	reviewed
O75251	BXGT005107	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	374291	reviewed
O75306	BXGT005108	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	4720	reviewed	Enzyme
O75489	BXGT005131	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	4722	reviewed
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
O95278	BXGT005370	Laforin	7957	reviewed
O95299	BXGT005372	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	4705	reviewed	Enzyme
O95363	BXGT005375	Phenylalanine--tRNA ligase, mitochondrial	10667	reviewed	Enzyme
O95622	BXGT005386	Adenylate cyclase type 5	111	reviewed
P00326	BXGT005499	Alcohol dehydrogenase 1C	126	reviewed	Enzyme
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	3251	reviewed	Enzyme
P00846	BXGT005674	ATP synthase subunit a	4508	reviewed	Transporter
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P02708	BXGT005927	Acetylcholine receptor subunit alpha	1134	reviewed	Ion channel
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02792	BXGT005966	Ferritin light chain	2512	reviewed	Storage
P03886	BXGT006108	NADH-ubiquinone oxidoreductase chain 1	4535	reviewed	Enzyme
P03905	BXGT006113	NADH-ubiquinone oxidoreductase chain 4	4538	reviewed	Enzyme
P03915	BXGT006114	NADH-ubiquinone oxidoreductase chain 5	4540	reviewed	Enzyme
P03923	BXGT006115	NADH-ubiquinone oxidoreductase chain 6	4541	reviewed
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04156	BXGT006156	Major prion protein	5621	reviewed
P04350	BXGT006193	Tubulin beta-4A chain	10382	reviewed	Cellular structure
P05129	BXGT006322	Protein kinase C gamma type	5582	reviewed	Kinase
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07602	BXGT006646	Prosaposin	5660	reviewed
P07686	BXGT006657	Beta-hexosaminidase subunit beta	3074	reviewed	Enzyme
P07737	BXGT006663	Profilin-1	5216	reviewed
P07902	BXGT006697	Galactose-1-phosphate uridylyltransferase	2592	reviewed	Enzyme
P08034	BXGT006716	Gap junction beta-1 protein	2705	reviewed	Cell-cell junction
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P08559	BXGT006788	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	5160	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10301	BXGT007556	Ras-related protein R-Ras	6237	reviewed	Enzyme modulator
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12235	BXGT007774	ADP/ATP translocase 1	291	reviewed	Transporter
P13637	BXGT007933	Sodium/potassium-transporting ATPase subunit alpha-3	478	reviewed	Transporter
P13639	BXGT007934	Elongation factor 2	1938	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19404	BXGT008477	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	4729	reviewed
P19634	BXGT008504	Sodium/hydrogen exchanger 1	6548	reviewed	Transporter
P20711	BXGT008594	Aromatic-L-amino-acid decarboxylase	1644	reviewed
P21817	BXGT008693	Ryanodine receptor 1	6261	reviewed	Ion channel
P22033	BXGT008721	Methylmalonyl-CoA mutase, mitochondrial	4594	reviewed	Enzyme
P22459	BXGT008773	Potassium voltage-gated channel subfamily A member 4	3739	reviewed	Ion channel
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P28331	BXGT009252	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	4719	reviewed	Enzyme
P30084	BXGT009398	Enoyl-CoA hydratase, mitochondrial	1892	reviewed	Enzyme
P30531	BXGT009432	Sodium- and chloride-dependent GABA transporter 1	6529	reviewed	Transporter
P31040	BXGT009503	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	6389	reviewed	Enzyme
P34949	BXGT009775	Mannose-6-phosphate isomerase	4351	reviewed	Enzyme
P35219	BXGT009797	Carbonic anhydrase-related protein	767	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35270	BXGT009807	Sepiapterin reductase	6697	reviewed
P35462	BXGT009835	D(3) dopamine receptor	1814	reviewed	G-protein coupled receptor
P35914	BXGT009880	Hydroxymethylglutaryl-CoA lyase, mitochondrial	3155	reviewed	Enzyme
P36021	BXGT009893	Monocarboxylate transporter 8	6567	reviewed	Transporter
P36507	BXGT009923	Dual specificity mitogen-activated protein kinase kinase 2	5605	reviewed	Kinase
P36894	BXGT009939	Bone morphogenetic protein receptor type-1A	657	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P40225	BXGT010168	Thrombopoietin	7066	reviewed
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P43003	BXGT010347	Excitatory amino acid transporter 1	6507	reviewed	Transporter
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P43354	BXGT010381	Nuclear receptor subfamily 4 group A member 2	4929	reviewed	Nuclear receptor
P48506	BXGT010635	Glutamate--cysteine ligase catalytic subunit	2729	reviewed	Enzyme
P48547	BXGT010643	Potassium voltage-gated channel subfamily C member 1	3746	reviewed	Ion channel
P48637	BXGT010649	Glutathione synthetase	2937	reviewed	Enzyme
P49448	BXGT010709	Glutamate dehydrogenase 2, mitochondrial	2747	reviewed	Enzyme
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49638	BXGT010720	Alpha-tocopherol transfer protein	7274	reviewed	Transporter
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49792	BXGT010743	E3 SUMO-protein ligase RanBP2	5903	reviewed	Enzyme modulator
P49821	BXGT010748	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	4723	reviewed
P49959	BXGT010766	Double-strand break repair protein MRE11	4361	reviewed
P50993	BXGT010826	Sodium/potassium-transporting ATPase subunit alpha-2	477	reviewed	Transporter
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P52788	BXGT010953	Spermine synthase	6611	reviewed
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54136	BXGT011033	Arginine--tRNA ligase, cytoplasmic	5917	reviewed
P54278	BXGT011038	Mismatch repair endonuclease PMS2	5395	reviewed	Nucleic acid binding
P54886	BXGT011092	Delta-1-pyrroline-5-carboxylate synthase	5832	reviewed	Enzyme
P55072	BXGT011103	Transitional endoplasmic reticulum ATPase	7415	reviewed
P55265	BXGT011117	Double-stranded RNA-specific adenosine deaminase	103	reviewed	Enzyme
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P60891	BXGT011337	Ribose-phosphate pyrophosphokinase 1	5631	reviewed	Kinase
P84074	BXGT012030	Neuron-specific calcium-binding protein hippocalcin	3208	reviewed
P98155	BXGT012226	Very low-density lipoprotein receptor	7436	reviewed
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q04844	BXGT012789	Acetylcholine receptor subunit epsilon	1145	reviewed	Ion channel
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06210	BXGT012864	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	2673	reviewed	Enzyme
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q07889	BXGT012946	Son of sevenless homolog 1	6654	reviewed	Enzyme modulator
Q09470	BXGT013037	Potassium voltage-gated channel subfamily A member 1	3736	reviewed	Ion channel
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q13144	BXGT013317	Translation initiation factor eIF-2B subunit epsilon	8893	reviewed
Q13148	BXGT013318	TAR DNA-binding protein 43	23435	reviewed
Q13255	BXGT013332	Metabotropic glutamate receptor 1	2911	reviewed	G-protein coupled receptor
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13426	BXGT013353	DNA repair protein XRCC4	7518	reviewed
Q13472	BXGT013360	DNA topoisomerase 3-alpha	7156	reviewed	Enzyme
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q13509	BXGT013366	Tubulin beta-3 chain	10381	reviewed	Cellular structure
Q14003	BXGT013434	Potassium voltage-gated channel subfamily C member 3	3748	reviewed	Ion channel
Q14108	BXGT013440	Lysosome membrane protein 2	950	reviewed	Receptor
Q14203	BXGT013455	Dynactin subunit 1	1639	reviewed	Chaperone
Q14232	BXGT013457	Translation initiation factor eIF-2B subunit alpha	1967	reviewed
Q14643	BXGT013493	Inositol 1,4,5-trisphosphate receptor type 1	3708	reviewed	Ion channel
Q14671	BXGT013496	Pumilio homolog 1	9698	reviewed	Nucleic acid binding
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16566	BXGT013639	Calcium/calmodulin-dependent protein kinase type IV	814	reviewed	Kinase
Q16595	BXGT013643	Frataxin, mitochondrial	2395	reviewed	Enzyme
Q16795	BXGT013671	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	4704	reviewed	Enzyme
Q16828	BXGT013676	Dual specificity protein phosphatase 6	1848	reviewed
Q5JTZ9	BXGT015458	Alanine--tRNA ligase, mitochondrial	57505	reviewed	Nucleic acid binding
Q6PI48	BXGT016471	Aspartate--tRNA ligase, mitochondrial	55157	reviewed	Enzyme
Q7LG56	BXGT016999	Ribonucleoside-diphosphate reductase subunit M2 B	50484	reviewed	Enzyme
Q7Z2E3	BXGT017246	Aprataxin	54840	reviewed	Nucleic acid binding
Q86SX6	BXGT017601	Glutaredoxin-related protein 5, mitochondrial	51218	reviewed	Enzyme
Q8N183	BXGT018497	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	91942	reviewed
Q8TD30	BXGT018805	Alanine aminotransferase 2	84706	reviewed	Enzyme
Q8WXF7	BXGT019011	Atlastin-1	51062	reviewed	Enzyme modulator
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q92743	BXGT019368	Serine protease HTRA1	5654	reviewed	Enzyme
Q92963	BXGT019401	GTP-binding protein Rit1	6016	reviewed	Enzyme modulator
Q96PY6	BXGT019712	Serine/threonine-protein kinase Nek1	4750	reviewed	Kinase
Q96T60	BXGT019745	Bifunctional polynucleotide phosphatase/kinase	11284	reviewed
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q99574	BXGT019936	Neuroserpin	5274	reviewed	Enzyme modulator
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q99714	BXGT019954	3-hydroxyacyl-CoA dehydrogenase type-2	3028	reviewed	Enzyme
Q99720	BXGT019955	Sigma non-opioid intracellular receptor 1	10280	reviewed
Q9BV79	BXGT020141	Enoyl-[acyl-carrier-protein] reductase, mitochondrial	51102	reviewed
Q9BZ23	BXGT020194	Pantothenate kinase 2, mitochondrial	80025	reviewed	Kinase
Q9GZZ9	BXGT020430	Ubiquitin-like modifier-activating enzyme 5	79876	reviewed	Enzyme
Q9H4W6	BXGT020478	Transcription factor COE3	253738	reviewed
Q9HCG7	BXGT020533	Non-lysosomal glucosylceramidase	57704	reviewed
Q9HD40	BXGT020542	O-phosphoseryl-tRNA(Sec) selenium transferase	51091	reviewed
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	55775	reviewed	Enzyme
Q9NW15	BXGT021229	Anoctamin-10	55129	reviewed
Q9NX46	BXGT021243	ADP-ribose glycohydrolase ARH3	54936	reviewed
Q9NY47	BXGT021249	Voltage-dependent calcium channel subunit alpha-2/delta-2	9254	reviewed	Ion channel
Q9NZJ4	BXGT021274	Sacsin	26278	reviewed
Q9P0J0	BXGT021287	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	51079	reviewed	Enzyme
Q9UHD2	BXGT021697	Serine/threonine-protein kinase TBK1	29110	reviewed	Kinase
Q9UI09	BXGT021710	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	55967	reviewed
Q9UK17	BXGT021735	Potassium voltage-gated channel subfamily D member 3	3752	reviewed	Ion channel
Q9UMX1	BXGT021778	Suppressor of fused homolog	51684	reviewed
Q9UPT6	BXGT021801	C-Jun-amino-terminal kinase-interacting protein 3	23162	reviewed	Enzyme modulator
Q9Y233	BXGT022210	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	10846	reviewed
Q9Y234	BXGT022211	Lipoyltransferase 1, mitochondrial	51601	reviewed	Enzyme
Q9Y2M0	BXGT022241	Fanconi-associated nuclease 1	22909	reviewed
Q9Y3I1	BXGT022260	F-box only protein 7	25793	reviewed
Q9NYP7	BXGT022661	Elongation of very long chain fatty acids protein 5	60481	reviewed	Enzyme
Q5KSL6	BXGT022671	Diacylglycerol kinase kappa	139189	reviewed	Enzyme
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
Q9UBP0	BXGT023601	Spastin	6683	reviewed	Cellular structure
P35670	BXGT023695	Copper-transporting ATPase 2	540	reviewed	Transporter
Q53GS7	BXGT023762	Nucleoporin GLE1	2733	reviewed	Transporter
Q9UNE7	BXGT025000	E3 ubiquitin-protein ligase CHIP	10273	reviewed
Q9Y4W6	BXGT025025	AFG3-like protein 2	10939	reviewed	Enzyme
Q96DA2	BXGT025522	Ras-related protein Rab-39B	116442	reviewed
P28715	BXGT025675	DNA repair protein complementing XP-G cells	2073	reviewed
Q6IQ55	BXGT025689	Tau-tubulin kinase 2	146057	reviewed	Kinase
Q96MF2	BXGT025769	SH3 and cysteine-rich domain-containing protein 3	246329	reviewed
P35251	BXGT025853	Replication factor C subunit 1	5981	reviewed
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme
P61916	BXGT025881	NPC intracellular cholesterol transporter 2	10577	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}