Showing entry for SLIT-ROBO Rho GTPase-activating protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005097
Protein NameSLIT-ROBO Rho GTPase-activating protein 2
Uniport IdO75044
GeneSRGAP2
Gene Id23380
DomainFCH; RhoGAP; SH3_1
Pfam PF00611   PF00620   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051014 actin filament severing
Biological Process GO:0060996 dendritic spine development
Biological Process GO:0021816 extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration
Biological Process GO:0046847 filopodium assembly
Biological Process GO:0003363 lamellipodium assembly involved in ameboidal cell migration
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:2001223 negative regulation of neuron migration
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0043547 positive regulation of GTPase activity
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007165 signal transduction
Biological Process GO:0034446 substrate adhesion-dependent cell spreading
molecular function GO:0005096 GTPase activator activity
molecular function GO:0042802 identical protein binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0048365 Rac GTPase binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0044327 dendritic spine head
cellular component GO:0030027 lamellipodium
cellular component GO:0005654 nucleoplasm
cellular component GO:0045335 phagocytic vesicle
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0045211 postsynaptic membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194840 Rho GTPase cycle
R-HSA-195258 RHO GTPase Effectors
R-HSA-376176 Signaling by ROBO receptors
R-HSA-422475 Axon guidance
R-HSA-428543 Inactivation of CDC42 and RAC1
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0020217 BXGD001365 Hydatidiform Mole Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0025202 BXGD001832 melanoma Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027658 BXGD002011 Neoplasms, Germ Cell and Embryonal Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3463897 BXGD018900 HYDATIDIFORM MOLE, RECURRENT, 1
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4552072 BXGD023482 X-linked infantile spasms Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004187 D-Malic acid 134.09
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein