Showing entry for D-Malic acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0004187
Compound NameD-Malic acid
Structure
FormulaC4H6O5
InchiKeyBJEPYKJPYRNKOW-UWTATZPHSA-N
SMILESO[C@H](CC(O)=O)C(O)=O
InchiInChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m1/s1
IUPAC(2R)-2-hydroxybutanedioic acid
Molecular Weight134.09
Pubchem Id92824
Chembl IdCHEMBL225986
Targets of Information Source
DrugBank DB03499
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P74645 BXGT011739 Circadian clock protein KaiB reviewed - kaiB experimental -
P05042 BXGT006300 Fumarate hydratase class II reviewed - fumC experimental -
P9WK17 BXGT012353 Malate synthase G reviewed - glcB experimental -
P23368 BXGT008856 NAD-dependent malic enzyme, mitochondrial reviewed Enzyme ME2 experimental -
O75390 BXGT005123 Citrate synthase, mitochondrial reviewed Enzyme CS experimental -
Q57265 BXGT015115 Capsule biosynthesis protein unreviewed - synC experimental -
PDB MLT
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P23007 BXGT008826 Citrate synthase, mitochondrial reviewed CS - - - - -
P05042 BXGT006300 Fumarate hydratase class II reviewed fumC - - - - -
P9WK17 BXGT012353 Malate synthase G reviewed glcB - - - - -
P0A786 BXGT007099 Aspartate carbamoyltransferase catalytic subunit reviewed pyrB - - - - -
P93114 BXGT012115 Lectin reviewed - - - - -
P23368 BXGT008856 NAD-dependent malic enzyme, mitochondrial reviewed ME2 Enzyme - - - -
P74645 BXGT011739 Circadian clock protein KaiB reviewed kaiB - - - - -
O57767 BXGT004761 Quinolinate synthase A reviewed nadA - - - - -
Q57265 BXGT015115 Capsule biosynthesis protein unreviewed synC - - - - -
P55211 BXGT011111 Caspase-9 reviewed CASP9 Enzyme - - - -
P9WK65 BXGT012357 Putative phthiocerol dimycocerosate transporter LppX reviewed lppX - - - - -
P40926 BXGT010207 Malate dehydrogenase, mitochondrial reviewed MDH2 Enzyme - - - -
P24305 BXGT008962 Outer membrane porin protein 32 reviewed omp32 - - - - -
O43175 BXGT004575 D-3-phosphoglycerate dehydrogenase reviewed PHGDH Enzyme - - - -
Q9BVJ7 BXGT020145 Dual specificity protein phosphatase 23 reviewed DUSP23 - - - - -
P78504 BXGT011844 Protein jagged-1 reviewed JAG1 - - - - -
P9WIC1 BXGT012316 Intracellular chorismate mutase reviewed Rv0948c - - - - -
P22523 BXGT008780 Chromosome partition protein MukB reviewed mukB - - - - -
Q9WZQ4 BXGT022033 Probable 2-phosphosulfolactate phosphatase reviewed comB - - - - -
Q93ZN9 BXGT019547 LL-diaminopimelate aminotransferase, chloroplastic reviewed DAP - - - - -
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 reviewed PTPN11 - - - - -
P0AEC8 BXGT007308 Sensor histidine kinase DcuS reviewed dcuS - - - - -
Q8ZNF9 BXGT019220 L-rhamnonate dehydratase reviewed rhmD - - - - -
P59310 BXGT011266 N-acetyl-gamma-glutamyl-phosphate reductase reviewed argC - - - - -
P16692 BXGT008258 Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase reviewed phnP - - - - -
A0A3Q0L2Q1 BXGT022700 General secretion pathway protein G unreviewed gspG - - - - -
P27707 BXGT009201 Deoxycytidine kinase reviewed DCK Kinase - - - -
A5I6N2 BXGT001319 4-hydroxy-tetrahydrodipicolinate synthase unreviewed dapA - - - - -
P38636 BXGT010058 Metal homeostasis factor ATX1 reviewed ATX1 - - - - -
Q81ST7 BXGT017366 N-acetyl-alpha-D-glucosaminyl L-malate synthase reviewed bshA - - - - -
Q93NW7 BXGT019515 AmphB unreviewed amphB - - - - -
Q9I6R5 BXGT020773 Probable dihydrodipicolinate synthetase unreviewed PA0223 - - - - -
Q5S3G7 BXGT015651 Fluorescent protein plum unreviewed - - - - -
Q9CJC1 BXGT020243 Uncharacterized protein unreviewed yahD - - - - -
Q0P8W7 BXGT013120 Biotin carboxylase unreviewed accC - - - - -
Q2TWF5 BXGT014225 Uncharacterized protein unreviewed AO090010000582 - - - - -
P0A7H3 BXGT007116 DNA repair protein RecO reviewed recO - - - - -
P9WJB7 BXGT012337 Nucleoid-associated protein EspR reviewed espR - - - - -
Q8A5V9 BXGT017833 Putative beta-phosphoglucomutase unreviewed BT_2127 - - - - -
D1C982 BXGT002811 Alpha/beta hydrolase fold protein unreviewed Sthe_2971 - - - - -
A0A0H3LYP5 BXGT000480 Chorismate mutase protein unreviewed tyrA - - - - -
B2UCA8 BXGT002011 D-galactonate dehydratase reviewed dgoD - - - - -
B1MGB2 BXGT001898 Methionine aminopeptidase unreviewed map - - - - -
Q2T095 BXGT014200 Pantothenate synthetase reviewed panC - - - - -
Q9H492 BXGT020472 Microtubule-associated proteins 1A/1B light chain 3A reviewed MAP1LC3A Cellular structure - - - -
Q06121 BXGT012855 Indole-3-glycerol phosphate synthase reviewed trpC - - - - -
A0A023GPI5 BXGT000004 CBIX unreviewed - - - - -
Q8Y850 BXGT019099 Lmo1068 protein unreviewed lmo1068 - - - - -
A0A0F6B221 BXGT000181 Putative cytoplasmic protein unreviewed yciF - - - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed MMP9 Enzyme - - - -
Q89F76 BXGT017740 ABC transporter substrate-binding protein unreviewed bll6825 - - - - -
Q9KTQ6 BXGT021001 Accessory colonization factor AcfC unreviewed VC_0841 - - - - -
P30615 BXGT009448 Pyruvate kinase 1 reviewed PYK1 - - - - -
S8GQK2 BXGT022542 Ribulose 5-phosphate isomerase unreviewed TGME49_239310 - - - - -
Q0C365 BXGT013063 Enoyl-CoA hydratase/isomerase family protein unreviewed HNE_1107 - - - - -
A3PQL6 BXGT001179 TRAP dicarboxylate transporter, DctP subunit unreviewed Rsph17029_3541 - - - - -
Q5NFG1 BXGT015585 Macrophage growth locus, subunit A unreviewed mglA - - - - -
A0A0M3KKY6 BXGT000556 Esterase unreviewed - - - - -
Q385Q9 BXGT014346 Aspartate aminotransferase, mitochondrial unreviewed Tb11.02.2740 - - - - -
P9WFX5 BXGT012254 Anthranilate phosphoribosyltransferase reviewed trpD - - - - -
P06126 BXGT006412 T-cell surface glycoprotein CD1a reviewed CD1A - - - - -
Q88QV5 BXGT017729 Coenzyme PQQ synthesis protein B reviewed pqqB - - - - -
Q10714 BXGT013206 Angiotensin-converting enzyme reviewed Ance - - - - -
G0S6M7 BXGT003395 Probable vacuolar protein sorting-associated protein 16 homolog unreviewed CTHT_0026760 - - - - -
Q4JH30 BXGT014827 Acidocalcisomal pyrophosphatase unreviewed C3747_44g24 - - - - -
Q9JMB8 BXGT020840 Contactin-6 reviewed Cntn6 - - - - -
Q05909 BXGT012843 Receptor-type tyrosine-protein phosphatase gamma reviewed Ptprg - - - - -
A0A384LMS9 BXGT000818 2',3'-cyclic-nucleotide 2'-phosphodiesterase unreviewed cpdB - - - - -
P42212 BXGT010284 Green fluorescent protein reviewed GFP - - - - -
O75044 BXGT005097 SLIT-ROBO Rho GTPase-activating protein 2 reviewed SRGAP2 Enzyme modulator - - - -
I6XG39 BXGT003709 Genome polyprotein unreviewed - - - - -
G3XD33 BXGT003492 Heme acquisition protein HasAp unreviewed hasAp - - - - -
O53611 BXGT004707 Isocitrate dehydrogenase [NADP] unreviewed icd2 - - - - -
Q58261 BXGT015182 Tetrahydromethanopterin S-methyltransferase subunit A reviewed mtrA - - - - -
P02689 BXGT005919 Myelin P2 protein reviewed PMP2 - - - - -
A0A2B6C3P9 BXGT000778 Uncharacterized protein unreviewed GBAA_1561 - - - - -
P08069 BXGT006723 Insulin-like growth factor 1 receptor reviewed IGF1R Kinase - - - -
Q56905 BXGT015103 dTDP-4-dehydrorhamnose reductase unreviewed wbbW - - - - -
P32021 BXGT009596 2-oxoglutarate-dependent ethylene/succinate-forming enzyme reviewed efe - - - - -
C5XC49 BXGT002527 Uncharacterized protein unreviewed SORBI_3002G195400 - - - - -
C3W5S0 BXGT002458 Polymerase acidic protein unreviewed PA - - - - -
Q9CQV8 BXGT020250 14-3-3 protein beta/alpha reviewed Ywhab - - - - -
Q6PIF6 BXGT016473 Unconventional myosin-VIIb reviewed MYO7B Cellular structure - - - -
A0A229Y1X4 BXGT000773 Thioredoxin reductase unreviewed TRR1 - - - - -
B4EEF2 BXGT002110 Dihydrolipoyl dehydrogenase unreviewed lpdV - - - - -
Q8ZFU4 BXGT019176 Dihydroorotase reviewed pyrC - - - - -
Q92SA6 BXGT019436 Polyphosphate:ADP phosphotransferase 1 reviewed SMc02148 - - - - -
P9WFX9 BXGT012256 Tryptophan synthase beta chain reviewed trpB - - - - -
J3BZS6 BXGT003731 L-lysine 4-hydroxylase reviewed PMI10_03368 - - - - -
Q70I53 BXGT016672 Histone deacetylase-like amidohydrolase reviewed hdaH - - - - -
G3I8R9 BXGT003477 Endoplasmic reticulum chaperone BiP reviewed HSPA5 - - - - -
A0A088E2H7 BXGT024315 Malate dehydrogenase unreviewed HA72_0455 - - - - -
Q1RQU8 BXGT024714 Putative hydrolase unreviewed SAMT0137 - - - - -
A0A2H4T920 BXGT024754 Taurine catabolism dioxygenase unreviewed - - - - -
B5ZA44 BXGT025200 Guanosine pentaphosphate phosphohydrolase unreviewed HPG27_257 - - - - -
H2VFG5 BXGT025246 N-acetylneuraminate synthase unreviewed synC - - - - -
Q9NZ08 BXGT021266 Endoplasmic reticulum aminopeptidase 1 reviewed ERAP1 Enzyme - - - -
Q84KR7 BXGT025698 Phosphoenolpyruvate carboxylase unreviewed ppc1 - - - - -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed IDH1 - - - - -
Binding DB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
CHEMBL CHEMBL225986
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 1258 nM
P40495 BXGT010187 Homoisocitrate dehydrogenase, mitochondrial reviewed - LYS12 Activity - - -
P80244 BXGT011887 ATP-dependent Clp protease proteolytic subunit reviewed - clpP Potency - 3981 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 3981 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00040 Pepper (C. annuum) Capsicum annuum Vegetables
BXGF00049 Chicory Cichorium intybus Vegetables
BXGF00087 Sea-buckthornberry Hippophae rhamnoides Fruits
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00818 Herbs and Spices Herbs and Spices
BXGF01140 Angelica gigas Angelica gigas Medicinal Plant
BXGF01147 Chelidonium majus Chelidonium majus Medicinal Plant
BXGF01185 Aloe vera Aloe vera Medicinal Plant
BXGF01426 Cornus officinalis Cornus officinalis Medicinal Plant
BXGF01900 Aloe ferox Aloe ferox Medicinal Plant
BXGF01911 Bupleurum scorzonerifolium Bupleurum scorzonerifolium Medicinal Plant
BXGF02049 Angelica sinensis Angelica sinensis Medicinal Plant
BXGF02377 Cichorium glandulosum Cichorium glandulosum Others
BXGF02787 Melia azedarach Melia azedarach Medicinal Plant
BXGF03488 Paeonia suffruticosa Paeonia suffruticosa Medicinal Plant
BXGF04573 Rubia akane Rubia akane Medicinal Plant
BXGF04631 Aloe spicata Aloe spicata Medicinal Plant
BXGF04659 Phyllanthus emblica Phyllanthus emblica Medicinal Plant
BXGF04712 Prunus mume Prunus mume Medicinal Plant
BXGF04842 Angelica acutiloba Angelica acutiloba Medicinal Plant
BXGF04875 Bupleurum chinense Bupleurum chinense Medicinal Plant
BXGF04889 Pogostemon cablin Pogostemon cablin Medicinal Plant
BXGF04909 Hippophae fructus Hippophae fructus Others
BXGF04926 Aloe africana Aloe africana Medicinal Plant
BXGF04981 Bupleurum falcatum Bupleurum falcatum Medicinal Plant
BXGF05210 Homalomena occulta Homalomena occulta Medicinal Plant
BXGF05297 Isatis tinctoria Isatis tinctoria Medicinal Plant
BXGF05421 Tussilago farfara Tussilago farfara Medicinal Plant
BXGF05571 Ziziphus jujuba Ziziphus jujuba Medicinal Plant
BXGF05834 Schisandra sphenanthera Schisandra sphenanthera Medicinal Plant
BXGF05977 Schisandra chinensis Schisandra chinensis Medicinal Plant
BXGF06143 Persicaria tinctoria Persicaria tinctoria Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease