Showing entry for Mental Retardation


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001866
Disease NameMental Retardation
Disease CUI IdC0025362
MeSH Codes C23   C16   C10   F03   F01  
Disease Class NamePathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id DOID:150  
Disease Ontology Class Namedisease of mental health
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A1Z1Q3 BXGT001069 ADP-ribose glycohydrolase MACROD2 140733 reviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O14936 BXGT004114 Peripheral plasma membrane protein CASK 8573 reviewed Kinase
O15119 BXGT004128 T-box transcription factor TBX3 6926 reviewed Transcription factor
O15120 BXGT004129 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 10555 reviewed
O15305 BXGT004152 Phosphomannomutase 2 5373 reviewed Enzyme
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O43854 BXGT004630 EGF-like repeat and discoidin I-like domain-containing protein 3 10085 reviewed Enzyme
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60488 BXGT004878 Long-chain-fatty-acid--CoA ligase 4 2182 reviewed Enzyme
O75044 BXGT005097 SLIT-ROBO Rho GTPase-activating protein 2 23380 reviewed Enzyme modulator
O75746 BXGT005148 Calcium-binding mitochondrial carrier protein Aralar1 8604 reviewed Transporter
O75914 BXGT005165 Serine/threonine-protein kinase PAK 3 5063 reviewed Kinase
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
O95831 BXGT005399 Apoptosis-inducing factor 1, mitochondrial 9131 reviewed Enzyme
P00156 BXGT005469 Cytochrome b 4519 reviewed
P00387 BXGT005525 NADH-cytochrome b5 reductase 3 1727 reviewed
P00439 BXGT005539 Phenylalanine-4-hydroxylase 5053 reviewed
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00558 BXGT005579 Phosphoglycerate kinase 1 5230 reviewed Kinase
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00918 BXGT005690 Carbonic anhydrase 2 760 reviewed
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P02458 BXGT005879 Collagen alpha-1(II) chain 1280 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04083 BXGT006147 Annexin A1 301 reviewed
P04424 BXGT006214 Argininosuccinate lyase 435 reviewed Enzyme
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06276 BXGT006430 Cholinesterase 590 reviewed
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08100 BXGT006725 Rhodopsin 6010 reviewed G-protein coupled receptor
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P08908 BXGT006837 5-hydroxytryptamine receptor 1A 3350 reviewed G-protein coupled receptor
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 1133 reviewed G-protein coupled receptor
P09417 BXGT006888 Dihydropteridine reductase 5860 reviewed Enzyme
P09884 BXGT006937 DNA polymerase alpha catalytic subunit 5422 reviewed
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10827 BXGT007623 Thyroid hormone receptor alpha 7067 reviewed Nuclear receptor
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11498 BXGT007714 Pyruvate carboxylase, mitochondrial 5091 reviewed Enzyme
P12273 BXGT007787 Prolactin-inducible protein 5304 reviewed
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P15036 BXGT008073 Protein C-ets-2 2114 reviewed Transcription factor
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P16473 BXGT008234 Thyrotropin receptor 7253 reviewed G-protein coupled receptor
P17735 BXGT008335 Tyrosine aminotransferase 6898 reviewed
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P20936 BXGT008619 Ras GTPase-activating protein 1 5921 reviewed Enzyme modulator
P21333 BXGT008638 Filamin-A 2316 reviewed
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21917 BXGT008707 D(4) dopamine receptor 1815 reviewed G-protein coupled receptor
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22304 BXGT008752 Iduronate 2-sulfatase 3423 reviewed
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25440 BXGT009044 Bromodomain-containing protein 2 6046 reviewed Epigenetic regulator
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29622 BXGT009370 Kallistatin 5267 reviewed Enzyme modulator
P30101 BXGT009402 Protein disulfide-isomerase A3 2923 reviewed
P30518 BXGT009428 Vasopressin V2 receptor 554 reviewed G-protein coupled receptor
P30566 BXGT009446 Adenylosuccinate lyase 158 reviewed Enzyme
P31327 BXGT009523 Carbamoyl-phosphate synthase [ammonia], mitochondrial 1373 reviewed Enzyme
P31943 BXGT009587 Heterogeneous nuclear ribonucleoprotein H 3187 reviewed Nucleic acid binding
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P32322 BXGT009624 Pyrroline-5-carboxylate reductase 1, mitochondrial 5831 reviewed
P35219 BXGT009797 Carbonic anhydrase-related protein 767 reviewed
P35475 BXGT009837 Alpha-L-iduronidase 3425 reviewed Enzyme
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P36021 BXGT009893 Monocarboxylate transporter 8 6567 reviewed Transporter
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P41229 BXGT010239 Lysine-specific demethylase 5C 8242 reviewed
P41250 BXGT010244 Glycine--tRNA ligase 2617 reviewed Enzyme
P41279 BXGT010254 Mitogen-activated protein kinase kinase kinase 8 1326 reviewed Kinase
P41594 BXGT010266 Metabotropic glutamate receptor 5 2915 reviewed G-protein coupled receptor
P42263 BXGT010295 Glutamate receptor 3 2892 reviewed Ion channel
P42658 BXGT010327 Dipeptidyl aminopeptidase-like protein 6 1804 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43003 BXGT010347 Excitatory amino acid transporter 1 6507 reviewed Transporter
P43005 BXGT010349 Excitatory amino acid transporter 3 6505 reviewed Transporter
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46934 BXGT010553 E3 ubiquitin-protein ligase NEDD4 4734 reviewed Enzyme
P48029 BXGT010606 Sodium- and chloride-dependent creatine transporter 1 6535 reviewed Transporter
P48051 BXGT010611 G protein-activated inward rectifier potassium channel 2 3763 reviewed Ion channel
P48058 BXGT010614 Glutamate receptor 4 2893 reviewed Ion channel
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial 3418 reviewed
P49711 BXGT010728 Transcriptional repressor CTCF 10664 reviewed Transcription factor
P49760 BXGT010735 Dual specificity protein kinase CLK2 1196 reviewed Kinase
P49888 BXGT010756 Estrogen sulfotransferase 6783 reviewed
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P50993 BXGT010826 Sodium/potassium-transporting ATPase subunit alpha-2 477 reviewed Transporter
P51114 BXGT010832 Fragile X mental retardation syndrome-related protein 1 8087 reviewed Nucleic acid binding
P51149 BXGT010835 Ras-related protein Rab-7a 7879 reviewed
P51531 BXGT010851 Probable global transcription activator SNF2L2 6595 reviewed Epigenetic regulator
P51532 BXGT010852 Transcription activator BRG1 6597 reviewed Epigenetic regulator
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 6197 reviewed Kinase
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P52732 BXGT010948 Kinesin-like protein KIF11 3832 reviewed Cellular structure
P52788 BXGT010953 Spermine synthase 6611 reviewed
P54802 BXGT011081 Alpha-N-acetylglucosaminidase 4669 reviewed
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P61086 BXGT011357 Ubiquitin-conjugating enzyme E2 K 3093 reviewed
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P63027 BXGT011487 Vesicle-associated membrane protein 2 6844 reviewed
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P69905 BXGT011649 Hemoglobin subunit alpha 3040 reviewed
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q00604 BXGT012538 Norrin 4693 reviewed
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q01538 BXGT012597 Myelin transcription factor 1 4661 reviewed Transcription factor
Q01968 BXGT012626 Inositol polyphosphate 5-phosphatase OCRL-1 4952 reviewed Enzyme
Q05586 BXGT012826 Glutamate receptor ionotropic, NMDA 1 2902 reviewed Ion channel
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q12756 BXGT013261 Kinesin-like protein KIF1A 547 reviewed Cellular structure
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A 2903 reviewed Ion channel
Q13002 BXGT013303 Glutamate receptor ionotropic, kainate 2 2898 reviewed Ion channel
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13510 BXGT013367 Acid ceramidase 427 reviewed Enzyme
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q14118 BXGT013444 Dystroglycan 1605 reviewed Receptor
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q14831 BXGT013506 Metabotropic glutamate receptor 7 2917 reviewed G-protein coupled receptor
Q14978 BXGT013517 Nucleolar and coiled-body phosphoprotein 1 9221 reviewed
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 8851 reviewed Enzyme modulator
Q15485 BXGT013574 Ficolin-2 2220 reviewed Signaling
Q16099 BXGT013620 Glutamate receptor ionotropic, kainate 4 2900 reviewed Ion channel
Q2M1P5 BXGT014129 Kinesin-like protein KIF7 374654 reviewed
Q59FK2 BXGT015276 Selenocysteine lyase variant 51540 unreviewed
Q5JRX3 BXGT015457 Presequence protease, mitochondrial 10531 reviewed Enzyme
Q5VT25 BXGT015887 Serine/threonine-protein kinase MRCK alpha 8476 reviewed Kinase
Q71U36 BXGT016705 Tubulin alpha-1A chain 7846 reviewed Cellular structure
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q8N0W4 BXGT018492 Neuroligin-4, X-linked 57502 reviewed
Q8NEM0 BXGT018555 Microcephalin 79648 reviewed Nucleic acid binding
Q8WZA1 BXGT019024 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 55624 reviewed
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92796 BXGT019376 Disks large homolog 3 1741 reviewed
Q96I15 BXGT019674 Selenocysteine lyase 51540 reviewed Enzyme
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96SW2 BXGT019743 Protein cereblon 51185 reviewed Enzyme
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha 6326 reviewed Ion channel
Q99519 BXGT019928 Sialidase-1 4758 reviewed Enzyme
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 3028 reviewed Enzyme
Q9H1D0 BXGT020445 Transient receptor potential cation channel subfamily V member 6 55503 reviewed Ion channel
Q9H8M5 BXGT020496 Metal transporter CNNM2 54805 reviewed
Q9HBA0 BXGT020516 Transient receptor potential cation channel subfamily V member 4 59341 reviewed Ion channel
Q9NWB1 BXGT021231 RNA binding protein fox-1 homolog 1 54715 reviewed Nucleic acid binding
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha 6328 reviewed Ion channel
Q9NZN1 BXGT021279 Interleukin-1 receptor accessory protein-like 1 11141 reviewed Receptor
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase 1717 reviewed Enzyme
Q9UHY7 BXGT021709 Enolase-phosphatase E1 58478 reviewed Enzyme
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9UPP1 BXGT021800 Histone lysine demethylase PHF8 23133 reviewed
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q9UQD0 BXGT021811 Sodium channel protein type 8 subunit alpha 6334 reviewed Ion channel
Q9Y3B4 BXGT022255 Splicing factor 3B subunit 6 51639 reviewed
Q9Y3Q4 BXGT022264 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 10021 reviewed Ion channel
Q9Y5Y6 BXGT022308 Suppressor of tumorigenicity 14 protein 6768 reviewed Enzyme
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
P09622 BXGT023116 Dihydrolipoyl dehydrogenase, mitochondrial 1738 reviewed Enzyme
P51784 BXGT023311 Ubiquitin carboxyl-terminal hydrolase 11 8237 reviewed Enzyme
Q9UBP0 BXGT023601 Spastin 6683 reviewed Cellular structure
Q15583 BXGT024027 Homeobox protein TGIF1 7050 reviewed Enzyme
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
Q9H9S5 BXGT024623 Fukutin-related protein 79147 reviewed
Q96L73 BXGT024676 Histone-lysine N-methyltransferase, H3 lysine-36 specific 64324 reviewed Epigenetic regulator
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
Q05086 BXGT025648 Ubiquitin-protein ligase E3A 7337 reviewed
Q8TAB3 BXGT025819 Protocadherin-19 57526 reviewed
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
Q8WXI2 BXGT026145 Connector enhancer of kinase suppressor of ras 2 22866 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease