adisease

Showing entry for Chondrosarcoma

General Disease Information
BXGD Id	BXGD000544
Disease Name	Chondrosarcoma
Disease CUI Id	C0008479
MeSH Codes	C04
Disease Class Name	Neoplasms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0002664 HP:0000924
Human Phenotype Ontology Term	Neoplasm; Abnormality of the skeletal system
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14745	BXGT004090	Na(+)/H(+) exchange regulatory cofactor NHE-RF1	9368	reviewed
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O14757	BXGT004092	Serine/threonine-protein kinase Chk1	1111	reviewed	Kinase
O14788	BXGT004100	Tumor necrosis factor ligand superfamily member 11	8600	reviewed	Signaling
O15054	BXGT004121	Lysine-specific demethylase 6B	23135	reviewed	Epigenetic regulator
O15119	BXGT004128	T-box transcription factor TBX3	6926	reviewed	Transcription factor
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O15350	BXGT004154	Tumor protein p73	7161	reviewed	Transcription factor
O15550	BXGT004179	Lysine-specific demethylase 6A	7403	reviewed	Epigenetic regulator
O43854	BXGT004630	EGF-like repeat and discoidin I-like domain-containing protein 3	10085	reviewed	Enzyme
O60341	BXGT004873	Lysine-specific histone demethylase 1A	23028	reviewed	Epigenetic regulator
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75044	BXGT005097	SLIT-ROBO Rho GTPase-activating protein 2	23380	reviewed	Enzyme modulator
O75173	BXGT005105	A disintegrin and metalloproteinase with thrombospondin motifs 4	9507	reviewed	Enzyme
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O94925	BXGT005342	Glutaminase kidney isoform, mitochondrial	2744	reviewed	Enzyme
O95718	BXGT005392	Steroid hormone receptor ERR2	2103	reviewed	Nuclear receptor
O95835	BXGT005400	Serine/threonine-protein kinase LATS1	9113	reviewed	Kinase
P00338	BXGT005504	L-lactate dehydrogenase A chain	3939	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02760	BXGT005948	Protein AMBP	259	reviewed
P02765	BXGT005952	Alpha-2-HS-glycoprotein	197	reviewed	Enzyme modulator
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04003	BXGT006124	C4b-binding protein alpha chain	722	reviewed
P04049	BXGT006133	RAF proto-oncogene serine/threonine-protein kinase	5894	reviewed	Kinase
P04156	BXGT006156	Major prion protein	5621	reviewed
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05106	BXGT006315	Integrin beta-3	3690	reviewed	Receptor
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06756	BXGT006499	Integrin alpha-V	3685	reviewed
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P08151	BXGT006731	Zinc finger protein GLI1	2735	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08476	BXGT006774	Inhibin beta A chain	3624	reviewed	Signaling
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08758	BXGT006821	Annexin A5	308	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10600	BXGT007584	Transforming growth factor beta-3 proprotein	7043	reviewed	Signaling
P10646	BXGT007598	Tissue factor pathway inhibitor	7035	reviewed	Enzyme modulator
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10909	BXGT007630	Clusterin	1191	reviewed
P11137	BXGT007656	Microtubule-associated protein 2	4133	reviewed
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12724	BXGT007837	Eosinophil cationic protein	6037	reviewed
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13631	BXGT007929	Retinoic acid receptor gamma	5916	reviewed	Nuclear receptor
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16070	BXGT008186	CD44 antigen	960	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18075	BXGT008375	Bone morphogenetic protein 7	655	reviewed	Signaling
P19113	BXGT008458	Histidine decarboxylase	3067	reviewed
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P20248	BXGT008554	Cyclin-A2	890	reviewed	Enzyme modulator
P21709	BXGT008685	Ephrin type-A receptor 1	2041	reviewed	Kinase
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23526	BXGT008878	Adenosylhomocysteinase	191	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P27037	BXGT009153	Activin receptor type-2A	92	reviewed	Kinase
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29400	BXGT009343	Collagen alpha-5(IV) chain	1287	reviewed
P30304	BXGT009418	M-phase inducer phosphatase 1	993	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35462	BXGT009835	D(3) dopamine receptor	1814	reviewed	G-protein coupled receptor
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P39900	BXGT010148	Macrophage metalloelastase	4321	reviewed	Enzyme
P40337	BXGT010174	von Hippel-Lindau disease tumor suppressor	7428	reviewed	Enzyme
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41161	BXGT010229	ETS translocation variant 5	2119	reviewed	Transcription factor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43235	BXGT010368	Cathepsin K	1513	reviewed	Enzyme
P43490	BXGT010395	Nicotinamide phosphoribosyltransferase	10135	reviewed	Signaling
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46937	BXGT010554	Transcriptional coactivator YAP1	10413	reviewed	Enzyme modulator
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49747	BXGT010732	Cartilage oligomeric matrix protein	1311	reviewed
P49767	BXGT010739	Vascular endothelial growth factor C	7424	reviewed	Signaling
P50281	BXGT010788	Matrix metalloproteinase-14	4323	reviewed	Enzyme
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P50747	BXGT010817	Biotin--protein ligase	3141	reviewed	Enzyme
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P51790	BXGT010890	H(+)/Cl(-) exchange transporter 3	1182	reviewed	Ion channel
P52803	BXGT010958	Ephrin-A5	1946	reviewed	Signaling
P53350	BXGT010984	Serine/threonine-protein kinase PLK1	5347	reviewed	Kinase
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P55042	BXGT011100	GTP-binding protein RAD	6236	reviewed
P55210	BXGT011110	Caspase-7	840	reviewed	Enzyme
P58004	BXGT011222	Sestrin-2	83667	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P68363	BXGT011594	Tubulin alpha-1B chain	10376	reviewed	Cellular structure
P78325	BXGT011832	Disintegrin and metalloproteinase domain-containing protein 8	101	reviewed	Enzyme
P78358	BXGT011838	Cancer/testis antigen 1	246100	reviewed
P98160	BXGT012228	Basement membrane-specific heparan sulfate proteoglycan core protein	3339	reviewed	Enzyme modulator
P98170	BXGT012231	E3 ubiquitin-protein ligase XIAP	331	reviewed	Enzyme modulator
P99999	BXGT012235	Cytochrome c	54205	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q03431	BXGT012714	Parathyroid hormone/parathyroid hormone-related peptide receptor	5745	reviewed	G-protein coupled receptor
Q07817	BXGT012941	Bcl-2-like protein 1	598	reviewed	Signaling
Q13126	BXGT013313	S-methyl-5'-thioadenosine phosphorylase	4507	reviewed	Enzyme
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13509	BXGT013366	Tubulin beta-3 chain	10381	reviewed	Cellular structure
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q13546	BXGT013372	Receptor-interacting serine/threonine-protein kinase 1	8737	reviewed	Kinase
Q13873	BXGT013398	Bone morphogenetic protein receptor type-2	659	reviewed	Kinase
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q14623	BXGT013490	Indian hedgehog protein	3549	reviewed
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15596	BXGT013582	Nuclear receptor coactivator 2	10499	reviewed	Enzyme
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16666	BXGT013654	Gamma-interferon-inducible protein 16	3428	reviewed	Transcription factor
Q86V24	BXGT017615	Adiponectin receptor protein 2	79602	reviewed	Receptor
Q8TCG1	BXGT018797	Protein CIP2A	57650	reviewed
Q8TDU6	BXGT018814	G-protein coupled bile acid receptor 1	151306	reviewed	G-protein coupled receptor
Q8WUI4	BXGT018992	Histone deacetylase 7	51564	reviewed	Epigenetic regulator
Q96AC1	BXGT019617	Fermitin family homolog 2	10979	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q99835	BXGT019969	Smoothened homolog	6608	reviewed	G-protein coupled receptor
Q99873	BXGT019972	Protein arginine N-methyltransferase 1	3276	reviewed	Epigenetic regulator
Q9BUZ4	BXGT020139	TNF receptor-associated factor 4	9618	reviewed	Signaling
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NRA0	BXGT021183	Sphingosine kinase 2	56848	reviewed	Kinase
Q9NYA1	BXGT021254	Sphingosine kinase 1	8877	reviewed	Kinase
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UBN7	BXGT021658	Histone deacetylase 6	10013	reviewed	Epigenetic regulator
Q9UER7	BXGT021672	Death domain-associated protein 6	1616	reviewed
Q9UH17	BXGT021691	DNA dC->dU-editing enzyme APOBEC-3B	9582	reviewed	Enzyme
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y5W5	BXGT022303	Wnt inhibitory factor 1	11197	reviewed	Calcium-binding protein
Q96C86	BXGT022803	m7GpppX diphosphatase	28960	reviewed	Enzyme
Q9GZQ8	BXGT023414	Microtubule-associated proteins 1A/1B light chain 3B	81631	reviewed	Cellular structure
P08123	BXGT024477	Collagen alpha-2(I) chain	1278	reviewed
Q96A54	BXGT024681	Adiponectin receptor protein 1	51094	reviewed	Receptor
Q12888	BXGT024878	TP53-binding protein 1	7158	reviewed	Epigenetic regulator
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
P20809	BXGT025043	Interleukin-11	3589	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme
V9HWB9	BXGT026149	L-lactate dehydrogenase	3939	unreviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}