Showing entry for Formimidoyltransferase-cyclodeaminase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005408
Protein NameFormimidoyltransferase-cyclodeaminase
Uniport IdO95954
GeneFTCD
Gene Id10841
DomainFTCD; FTCD_C; FTCD_N
Pfam PF02971   PF04961   PF07837  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00340 Histidine metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00670 One carbon pool by folate
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007010 cytoskeleton organization
Biological Process GO:0006760 folic acid-containing compound metabolic process
Biological Process GO:0006548 histidine catabolic process
Biological Process GO:0019556 histidine catabolic process to glutamate and formamide
Biological Process GO:0019557 histidine catabolic process to glutamate and formate
Biological Process GO:0035999 tetrahydrofolate interconversion
molecular function GO:0005542 folic acid binding
molecular function GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity
molecular function GO:0030407 formimidoyltransferase activity
molecular function GO:0030409 glutamate formimidoyltransferase activity
molecular function GO:0008017 microtubule binding
cellular component GO:0005814 centriole
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000139 Golgi membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0030868 smooth endoplasmic reticulum membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-70921 Histidine catabolism
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002888 BXGD000145 Anemia, Megaloblastic Hemic and Lymphatic Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0028259 BXGD002073 Nodule
C0238621 BXGD004947 Aminoaciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0268605 BXGD006004 Inherited disorder of folate metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268609 BXGD006006 Glutamate formiminotransferase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0333980 BXGD006974 Focal Nodular Hyperplasia Digestive System Diseases
C0343640 BXGD007635 African Burkitt's lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0456070 BXGD008863 Growth delay
C0851887 BXGD010930 Adenoviral infections
C1269955 BXGD012005 Tumor Cell Invasion
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4025288 BXGD021628 Hypersegmentation of neutrophil nuclei
C4025589 BXGD021680 Positive ferric chloride test
C4721444 BXGD023742 Burkitt Leukemia Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0018829 Leucovorin 473.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein