Showing entry for Ferritin heavy chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005967
Protein NameFerritin heavy chain
Uniport IdP02794
GeneFTH1
Gene Id2495
DomainFerritin
Pfam PF00210  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04216 Ferroptosis
4. Cellular Processes 4.2 Cell growth and death hsa04217 Necroptosis
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006879 cellular iron ion homeostasis
Biological Process GO:0006955 immune response
Biological Process GO:0006880 intracellular sequestering of iron ion
Biological Process GO:0006826 iron ion transport
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0048147 negative regulation of fibroblast proliferation
Biological Process GO:0043312 neutrophil degranulation
molecular function GO:0008199 ferric iron binding
molecular function GO:0008198 ferrous iron binding
molecular function GO:0004322 ferroxidase activity
molecular function GO:0005506 iron ion binding
cellular component GO:0044754 autolysosome
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0008043 intracellular ferritin complex
cellular component GO:0005634 nucleus
cellular component GO:1904724 tertiary granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-3000480 Scavenging by Class A Receptors
R-HSA-382551 Transport of small molecules
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004604 BXGD000278 Back Pain Pathological Conditions, Signs and Symptoms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011119 BXGD000698 Decompression Sickness Wounds and Injuries
C0011573 BXGD000730 Endogenous depression Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015302 BXGD000974 External exotoses Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0022548 BXGD001551 Keloid Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024003 BXGD001726 Lordosis Musculoskeletal Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025193 BXGD001831 Melancholia Mental Disorders
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032927 BXGD002381 Precancerous Conditions Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038016 BXGD002727 Spondylolisthesis Musculoskeletal Diseases
C0038017 BXGD002728 Congenital spondylolisthesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042769 BXGD002999 Virus Diseases Infections
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086133 BXGD003265 Depressive Syndrome Mental Disorders
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0202177 BXGD004079 Phospholipid measurement
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0241013 BXGD005075 Increased serum ferritin
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0259783 BXGD005221 mixed gliomas Neoplasms
C0270715 BXGD006089 Degenerative Diseases, Central Nervous System Nervous System Diseases
C0271742 BXGD006254 Glucocorticoid deficiency with achalasia Digestive System Diseases; Endocrine System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0281899 BXGD006788 Prolapsed lumbar disc Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0282126 BXGD006796 Depression, Neurotic Mental Disorders
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0282313 BXGD006803 Condition, Preneoplastic Neoplasms
C0339510 BXGD007257 Vitelliform Macular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346957 BXGD007836 Disseminated Malignant Neoplasm Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0400877 BXGD008262 Postoperative ileus Digestive System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751733 BXGD010569 Degenerative Diseases, Spinal Cord Nervous System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1851316 BXGD015208 Iron Overload, Autosomal Dominant Nutritional and Metabolic Diseases
C1853578 BXGD015346 Neuroferritinopathy Nutritional and Metabolic Diseases; Nervous System Diseases
C1856689 BXGD015630 FRIEDREICH ATAXIA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1956089 BXGD016615 Osteophyte Musculoskeletal Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2676033 BXGD017322 Hepatoblastoma Caused By Somatic Mutation Digestive System Diseases; Neoplasms
C2747816 BXGD017577 Complicated malaria Infections
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3662483 BXGD019270 Allergic sensitization
C3714514 BXGD019409 Infection Infections
C3888198 BXGD019958 BESTROPHINOPATHY, AUTOSOMAL RECESSIVE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087521 BXGD022158 Adjacent segment disease
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0008661 Iron 55.85
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein