adisease

Showing entry for Iron Overload

General Disease Information
BXGD Id	BXGD006798
Disease Name	Iron Overload
Disease CUI Id	C0282193
MeSH Codes	C18
Disease Class Name	Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O95390	BXGT005377	Growth/differentiation factor 11	10220	reviewed	Signaling
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02656	BXGT005913	Apolipoprotein C-III	345	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P02792	BXGT005966	Ferritin light chain	2512	reviewed	Storage
P02794	BXGT005967	Ferritin heavy chain	2495	reviewed	Storage
P02818	BXGT005969	Osteocalcin	632	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05187	BXGT006339	Alkaline phosphatase, placental type	250	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P09917	BXGT006941	Arachidonate 5-lipoxygenase	240	reviewed	Enzyme
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P13236	BXGT007891	C-C motif chemokine 4	6351	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P19440	BXGT008481	Glutathione hydrolase 1 proenzyme	2678	reviewed	Enzyme
P21399	BXGT008646	Cytoplasmic aconitate hydratase	48	reviewed	Enzyme
P22004	BXGT008718	Bone morphogenetic protein 6	654	reviewed	Signaling
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22557	BXGT008783	5-aminolevulinate synthase, erythroid-specific, mitochondrial	212	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24298	BXGT008960	Alanine aminotransferase 1	2875	reviewed	Enzyme
P24557	BXGT008976	Thromboxane-A synthase	6916	reviewed
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29508	BXGT009358	Serpin B3	6317	reviewed	Enzyme modulator
P30044	BXGT009395	Peroxiredoxin-5, mitochondrial	25824	reviewed
P30533	BXGT009434	Alpha-2-macroglobulin receptor-associated protein	4043	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36894	BXGT009939	Bone morphogenetic protein receptor type-1A	657	reviewed	Kinase
P36969	BXGT009949	Phospholipid hydroperoxide glutathione peroxidase	2879	reviewed	Enzyme
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41180	BXGT010230	Extracellular calcium-sensing receptor	846	reviewed	G-protein coupled receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42858	BXGT010341	Huntingtin	3064	reviewed
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46939	BXGT010555	Utrophin	7402	reviewed
P48147	BXGT010620	Prolyl endopeptidase	5550	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49281	BXGT010689	Natural resistance-associated macrophage protein 2	4891	reviewed	Transporter
P49763	BXGT010737	Placenta growth factor	5228	reviewed	Signaling
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P55774	BXGT011124	C-C motif chemokine 18	6362	reviewed	Signaling
P58004	BXGT011222	Sestrin-2	83667	reviewed	Enzyme
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P68871	BXGT011615	Hemoglobin subunit beta	3043	reviewed
P69905	BXGT011649	Hemoglobin subunit alpha	3040	reviewed
P78536	BXGT011847	Disintegrin and metalloproteinase domain-containing protein 17	6868	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P81172	BXGT011935	Hepcidin	57817	reviewed
Q04771	BXGT012783	Activin receptor type-1	90	reviewed	Kinase
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07817	BXGT012941	Bcl-2-like protein 1	598	reviewed	Signaling
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13231	BXGT013329	Chitotriosidase-1	1118	reviewed
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q15554	BXGT013577	Telomeric repeat-binding factor 2	7014	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16549	BXGT013637	Proprotein convertase subtilisin/kexin type 7	9159	reviewed
Q16595	BXGT013643	Frataxin, mitochondrial	2395	reviewed	Enzyme
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q53TN4	BXGT015019	Cytochrome b reductase 1	79901	reviewed	Enzyme
Q6ZVN8	BXGT016641	Hemojuvelin	148738	reviewed
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q86SX6	BXGT017601	Glutaredoxin-related protein 5, mitochondrial	51218	reviewed	Enzyme
Q8N4E7	BXGT018511	Ferritin, mitochondrial	94033	reviewed	Storage
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q92859	BXGT019386	Neogenin	4756	reviewed
Q96AT9	BXGT019619	Ribulose-phosphate 3-epimerase	6120	reviewed
Q96D42	BXGT019636	Hepatitis A virus cellular receptor 1	26762	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96Q11	BXGT019713	CCA tRNA nucleotidyltransferase 1, mitochondrial	51095	reviewed
Q99527	BXGT019930	G-protein coupled estrogen receptor 1	2852	reviewed	G-protein coupled receptor
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BXA5	BXGT020163	Succinate receptor 1	56670	reviewed	G-protein coupled receptor
Q9BXM7	BXGT020172	Serine/threonine-protein kinase PINK1, mitochondrial	65018	reviewed	Kinase
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9UIK4	BXGT021720	Death-associated protein kinase 2	23604	reviewed	Kinase
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
P16615	BXGT023653	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	488	reviewed	Transporter
O15198	BXGT024049	Mothers against decapentaplegic homolog 9	4093	reviewed	Transcription factor
O43583	BXGT024866	Density-regulated protein	8562	reviewed	Enzyme
Q9H1K1	BXGT025766	Iron-sulfur cluster assembly enzyme ISCU, mitochondrial	23479	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}