Showing entry for Malignant mesothelioma


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD007756
Disease NameMalignant mesothelioma
Disease CUI IdC0345967
MeSH Codes C04   C08  
Disease Class NameNeoplasms; Respiratory Tract Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0002664  
Human Phenotype Ontology TermNeoplasm
Disease Ontology Id DOID:14566  
Disease Ontology Class Namedisease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00182 BXGT003889 Galectin-9 3965 reviewed Signaling
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00571 BXGT003938 ATP-dependent RNA helicase DDX3X 1654 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O15151 BXGT004132 Protein Mdm4 4194 reviewed Nucleic acid binding
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O60462 BXGT004876 Neuropilin-2 8828 reviewed
O75475 BXGT005130 PC4 and SFRS1-interacting protein 11168 reviewed Signaling
O76082 BXGT005175 Solute carrier family 22 member 5 6584 reviewed Transporter
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95696 BXGT005390 Bromodomain-containing protein 1 23774 reviewed
O95835 BXGT005400 Serine/threonine-protein kinase LATS1 9113 reviewed Kinase
O96020 BXGT005416 G1/S-specific cyclin-E2 9134 reviewed Enzyme modulator
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02748 BXGT005940 Complement component C9 735 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02787 BXGT005962 Serotransferrin 7018 reviewed Enzyme
P02794 BXGT005967 Ferritin heavy chain 2495 reviewed Storage
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05156 BXGT006329 Complement factor I 3426 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P05937 BXGT006396 Calbindin 793 reviewed Calcium-binding protein
P07099 BXGT006546 Epoxide hydrolase 1 2052 reviewed
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07355 BXGT006609 Annexin A2 302 reviewed
P08138 BXGT006729 Tumor necrosis factor receptor superfamily member 16 4804 reviewed Receptor
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08670 BXGT006810 Vimentin 7431 reviewed
P08700 BXGT006816 Interleukin-3 3562 reviewed
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09525 BXGT006901 Annexin A4 307 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10147 BXGT007543 C-C motif chemokine 3 6348 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10586 BXGT007581 Receptor-type tyrosine-protein phosphatase F 5792 reviewed Enzyme
P10599 BXGT007583 Thioredoxin 7295 reviewed
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 5292 reviewed Kinase
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12830 BXGT007852 Cadherin-1 999 reviewed
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src 6714 reviewed Kinase
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13726 BXGT007950 Tissue factor 2152 reviewed Receptor
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14784 BXGT008054 Interleukin-2 receptor subunit beta 3560 reviewed Receptor
P15328 BXGT008108 Folate receptor alpha 2348 reviewed
P15529 BXGT008134 Membrane cofactor protein 4179 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18827 BXGT008427 Syndecan-1 6382 reviewed Extracellular structure
P18846 BXGT008430 Cyclic AMP-dependent transcription factor ATF-1 466 reviewed
P18847 BXGT008431 Cyclic AMP-dependent transcription factor ATF-3 467 reviewed Transcription factor
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P19793 BXGT008515 Retinoic acid receptor RXR-alpha 6256 reviewed Nuclear receptor
P20472 BXGT008578 Parvalbumin alpha 5816 reviewed Calcium-binding protein
P21291 BXGT008635 Cysteine and glycine-rich protein 1 1465 reviewed Cellular structure
P21709 BXGT008685 Ephrin type-A receptor 1 2041 reviewed Kinase
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22223 BXGT008744 Cadherin-3 1001 reviewed
P23921 BXGT008927 Ribonucleoside-diphosphate reductase large subunit 6240 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24557 BXGT008976 Thromboxane-A synthase 6916 reviewed
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P27707 BXGT009201 Deoxycytidine kinase 1633 reviewed Kinase
P28908 BXGT009302 Tumor necrosis factor receptor superfamily member 8 943 reviewed
P29317 BXGT009331 Ephrin type-A receptor 2 1969 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29460 BXGT009348 Interleukin-12 subunit beta 3593 reviewed Signaling
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29622 BXGT009370 Kallistatin 5267 reviewed Enzyme modulator
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30279 BXGT009415 G1/S-specific cyclin-D2 894 reviewed Enzyme modulator
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32320 BXGT009622 Cytidine deaminase 978 reviewed Enzyme
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P33981 BXGT009744 Dual specificity protein kinase TTK 7272 reviewed Kinase
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35475 BXGT009837 Alpha-L-iduronidase 3425 reviewed Enzyme
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36896 BXGT009940 Activin receptor type-1B 91 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41439 BXGT010260 Folate receptor gamma 2352 reviewed
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P43405 BXGT010386 Tyrosine-protein kinase SYK 6850 reviewed Kinase
P43489 BXGT010394 Tumor necrosis factor receptor superfamily member 4 7293 reviewed
P45381 BXGT010460 Aspartoacylase 443 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48507 BXGT010636 Glutamate--cysteine ligase regulatory subunit 2730 reviewed Enzyme
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49767 BXGT010739 Vascular endothelial growth factor C 7424 reviewed Signaling
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P50281 BXGT010788 Matrix metalloproteinase-14 4323 reviewed Enzyme
P50479 BXGT010804 PDZ and LIM domain protein 4 8572 reviewed Cellular structure
P51531 BXGT010851 Probable global transcription activator SNF2L2 6595 reviewed Epigenetic regulator
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P54760 BXGT011075 Ephrin type-B receptor 4 2050 reviewed Kinase
P54762 BXGT011076 Ephrin type-B receptor 1 2047 reviewed Kinase
P56524 BXGT011176 Histone deacetylase 4 9759 reviewed Epigenetic regulator
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P78504 BXGT011844 Protein jagged-1 182 reviewed
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q10588 BXGT013202 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 683 reviewed Enzyme
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13126 BXGT013313 S-methyl-5'-thioadenosine phosphorylase 4507 reviewed Enzyme
Q13164 BXGT013322 Mitogen-activated protein kinase 7 5598 reviewed Kinase
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q13616 BXGT013381 Cullin-1 8454 reviewed Enzyme
Q13938 BXGT013405 Calcyphosin 828 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14627 BXGT013492 Interleukin-13 receptor subunit alpha-2 3598 reviewed Signaling
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q14914 BXGT013513 Prostaglandin reductase 1 22949 reviewed Enzyme
Q15047 BXGT013528 Histone-lysine N-methyltransferase SETDB1 9869 reviewed
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15485 BXGT013574 Ficolin-2 2220 reviewed Signaling
Q15599 BXGT013583 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 9351 reviewed
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16206 BXGT013623 Ecto-NOX disulfide-thiol exchanger 2 10495 reviewed Enzyme
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q16881 BXGT013688 Thioredoxin reductase 1, cytoplasmic 7296 reviewed Enzyme
Q2M385 BXGT014131 Macrophage-expressed gene 1 protein 219972 reviewed
Q86U86 BXGT017611 Protein polybromo-1 55193 reviewed Epigenetic regulator
Q8IYS5 BXGT018369 Osteoclast-associated immunoglobulin-like receptor 126014 reviewed
Q8IYT8 BXGT018370 Serine/threonine-protein kinase ULK2 9706 reviewed Kinase
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92736 BXGT019367 Ryanodine receptor 2 6262 reviewed Ion channel
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q92945 BXGT019397 Far upstream element-binding protein 2 8570 reviewed Enzyme
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q99835 BXGT019969 Smoothened homolog 6608 reviewed G-protein coupled receptor
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9NPH5 BXGT021159 NADPH oxidase 4 50507 reviewed Enzyme
Q9NR12 BXGT021174 PDZ and LIM domain protein 7 9260 reviewed Cellular structure
Q9NRM7 BXGT021190 Serine/threonine-protein kinase LATS2 26524 reviewed Kinase
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UH17 BXGT021691 DNA dC->dU-editing enzyme APOBEC-3B 9582 reviewed Enzyme
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9UKV8 BXGT021752 Protein argonaute-2 27161 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UMX1 BXGT021778 Suppressor of fused homolog 51684 reviewed
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y286 BXGT022225 Sialic acid-binding Ig-like lectin 7 27036 reviewed Receptor
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y5W5 BXGT022303 Wnt inhibitory factor 1 11197 reviewed Calcium-binding protein
Q9Y5Y6 BXGT022308 Suppressor of tumorigenicity 14 protein 6768 reviewed Enzyme
Q9Y678 BXGT022320 Coatomer subunit gamma-1 22820 reviewed Transporter
Q9Y6X2 BXGT022343 E3 SUMO-protein ligase PIAS3 10401 reviewed
P35240 BXGT022927 Merlin 4771 reviewed
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q92922 BXGT023066 SWI/SNF complex subunit SMARCC1 6599 reviewed Enzyme
P56703 BXGT023722 Proto-oncogene Wnt-3 7473 reviewed Signaling
Q13007 BXGT023883 Interleukin-24 11009 reviewed
Q8IX03 BXGT024000 Protein KIBRA 23286 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease