Showing entry for Thyroxine-binding globulin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006366
Protein NameThyroxine-binding globulin
Uniport IdP05543
GeneSERPINA7
Gene Id6906
DomainSerpin
Pfam PF00079  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0010951 negative regulation of endopeptidase activity
Biological Process GO:0070327 thyroid hormone transport
molecular function GO:0004867 serine-type endopeptidase inhibitor activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010308 BXGD000661 Congenital Hypothyroidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015190 BXGD000968 Euthyroid Sick Syndromes Endocrine System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0040156 BXGD002849 Thyrotoxicosis Endocrine System Diseases
C0086438 BXGD003283 Hypogammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0271815 BXGD006264 Postpartum Thyroiditis Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0271836 BXGD006268 X-linked reduction of thyroxine-binding globulin
C0342185 BXGD007439 Hyperthyroxinemia, Familial Dysalbuminemic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0342881 BXGD007572 Familial hypercholesterolemia - homozygous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0349486 BXGD007910 Transient hypothyroxinemia Endocrine System Diseases
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0744620 BXGD010103 Metastatic Head and Neck Squamous Cell Carcinoma Neoplasms
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1837475 BXGD014236 Insulin-Like Growth Factor I Deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1839141 BXGD014359 Thyroxine-Binding Globulin Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3711378 BXGD019385 Inherited Thyroxine-Binding Globulin Deficiency Endocrine System Diseases
C3840565 BXGD019797 Autoimmune thyroid disease (AITD)
C3890933 BXGD020027 THYROXINE-BINDING GLOBULIN, VARIANT A PHENOTYPE
C3890934 BXGD020028 THYROXINE-BINDING GLOBULIN, VARIANT P PHENOTYPE
C4016583 BXGD020345 THYROXINE-BINDING GLOBULIN, SLOW
C4016587 BXGD020346 THYROXINE-BINDING GLOBULIN, CHICAGO
C4302200 BXGD022529 Congenital central hypothyroidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C4329989 BXGD022795 Feline Oral Squamous Cell Carcinoma
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002616 Copper 63.55
BXGC0002698 Fluorine 19
BXGC0003705 Chloride 35.45
BXGC0025862 Levothyroxine 776.69
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein