adisease

Showing entry for Hyperthyroidism

General Disease Information
BXGD Id	BXGD001429
Disease Name	Hyperthyroidism
Disease CUI Id	C0020550
MeSH Codes	C19
Disease Class Name	Endocrine System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000818
Human Phenotype Ontology Term	Abnormality of the endocrine system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00255	BXGT003903	Menin	4221	reviewed
O75369	BXGT005119	Filamin-B	2317	reviewed
O75390	BXGT005123	Citrate synthase, mitochondrial	1431	reviewed	Enzyme
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00450	BXGT005544	Ceruloplasmin	1356	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P00915	BXGT005689	Carbonic anhydrase 1	759	reviewed
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02652	BXGT005910	Apolipoprotein A-II	336	reviewed	Transporter
P02656	BXGT005913	Apolipoprotein C-III	345	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02765	BXGT005952	Alpha-2-HS-glycoprotein	197	reviewed	Enzyme modulator
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02818	BXGT005969	Osteocalcin	632	reviewed
P03886	BXGT006108	NADH-ubiquinone oxidoreductase chain 1	4535	reviewed	Enzyme
P03905	BXGT006113	NADH-ubiquinone oxidoreductase chain 4	4538	reviewed	Enzyme
P03915	BXGT006114	NADH-ubiquinone oxidoreductase chain 5	4540	reviewed	Enzyme
P03923	BXGT006115	NADH-ubiquinone oxidoreductase chain 6	4541	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04083	BXGT006147	Annexin A1	301	reviewed
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05090	BXGT006311	Apolipoprotein D	347	reviewed
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05543	BXGT006366	Thyroxine-binding globulin	6906	reviewed	Enzyme modulator
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07355	BXGT006609	Annexin A2	302	reviewed
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08185	BXGT006742	Corticosteroid-binding globulin	866	reviewed	Enzyme modulator
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P08758	BXGT006821	Annexin A5	308	reviewed
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10827	BXGT007623	Thyroid hormone receptor alpha	7067	reviewed	Nuclear receptor
P10828	BXGT007624	Thyroid hormone receptor beta	7068	reviewed	Nuclear receptor
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11169	BXGT007664	Solute carrier family 2, facilitated glucose transporter member 3	6515	reviewed	Transporter
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P11597	BXGT007727	Cholesteryl ester transfer protein	1071	reviewed
P12235	BXGT007774	ADP/ATP translocase 1	291	reviewed	Transporter
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13224	BXGT007890	Platelet glycoprotein Ib beta chain	2812	reviewed
P13489	BXGT007913	Ribonuclease inhibitor	6050	reviewed	Transcription factor
P13671	BXGT007941	Complement component C6	729	reviewed
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14672	BXGT008037	Solute carrier family 2, facilitated glucose transporter member 4	6517	reviewed	Transporter
P15309	BXGT008105	Prostatic acid phosphatase	55	reviewed	Enzyme
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P19634	BXGT008504	Sodium/hydrogen exchanger 1	6548	reviewed	Transporter
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22680	BXGT008794	Cholesterol 7-alpha-monooxygenase	1581	reviewed	Enzyme
P25311	BXGT009036	Zinc-alpha-2-glycoprotein	563	reviewed
P25325	BXGT009038	3-mercaptopyruvate sulfurtransferase	4357	reviewed	Enzyme
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P29320	BXGT009332	Ephrin type-A receptor 3	2042	reviewed	Kinase
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29536	BXGT009361	Leiomodin-1	25802	reviewed	Cellular structure
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32929	BXGT009682	Cystathionine gamma-lyase	1491	reviewed	Enzyme
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P36021	BXGT009893	Monocarboxylate transporter 8	6567	reviewed	Transporter
P36969	BXGT009949	Phospholipid hydroperoxide glutathione peroxidase	2879	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P39019	BXGT010082	40S ribosomal protein S19	6223	reviewed	Nucleic acid binding
P42226	BXGT010288	Signal transducer and activator of transcription 6	6778	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43490	BXGT010395	Nicotinamide phosphoribosyltransferase	10135	reviewed	Signaling
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50052	BXGT010768	Type-2 angiotensin II receptor	186	reviewed	G-protein coupled receptor
P51692	BXGT010885	Signal transducer and activator of transcription 5B	6777	reviewed	Nucleic acid binding
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P55899	BXGT011131	IgG receptor FcRn large subunit p51	2217	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q06710	BXGT012887	Paired box protein Pax-8	7849	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q08828	BXGT013008	Adenylate cyclase type 1	107	reviewed
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13370	BXGT013345	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	5140	reviewed
Q13698	BXGT013392	Voltage-dependent L-type calcium channel subunit alpha-1S	779	reviewed	Ion channel
Q13822	BXGT013396	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	5168	reviewed	Enzyme
Q14032	BXGT013438	Bile acid-CoA:amino acid N-acyltransferase	570	reviewed
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q15831	BXGT013604	Serine/threonine-protein kinase STK11	6794	reviewed	Kinase
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16568	BXGT013640	Cocaine- and amphetamine-regulated transcript protein	9607	reviewed
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q7LG56	BXGT016999	Ribonucleoside-diphosphate reductase subunit M2 B	50484	reviewed	Enzyme
Q86VQ6	BXGT017620	Thioredoxin reductase 3	114112	reviewed	Enzyme
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96IY4	BXGT019678	Carboxypeptidase B2	1361	reviewed	Enzyme
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9H4A3	BXGT020473	Serine/threonine-protein kinase WNK1	65125	reviewed	Kinase
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9NNW7	BXGT021139	Thioredoxin reductase 2, mitochondrial	10587	reviewed	Enzyme
Q9NQV5	BXGT021170	PR domain-containing protein 11	56981	reviewed
Q9NZL9	BXGT021277	Methionine adenosyltransferase 2 subunit beta	27430	reviewed
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UL51	BXGT021754	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	610	reviewed	Ion channel
Q9Y233	BXGT022210	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	10846	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y376	BXGT022254	Calcium-binding protein 39	51719	reviewed	Calcium-binding protein
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y646	BXGT022317	Carboxypeptidase Q	10404	reviewed	Enzyme
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
P16615	BXGT023653	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	488	reviewed	Transporter
O75208	BXGT023882	Ubiquinone biosynthesis protein COQ9, mitochondrial	57017	reviewed
Q9BQQ3	BXGT024065	Golgi reassembly-stacking protein 1	64689	reviewed
Q96Q15	BXGT025610	Serine/threonine-protein kinase SMG1	23049	reviewed	Kinase
P33993	BXGT025970	DNA replication licensing factor MCM7	4176	reviewed	Enzyme
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}