Showing entry for Histone H1.0


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006594
Protein NameHistone H1.0
Uniport IdP07305
GeneH1-0
Gene Id3005
DomainLinker_histone
Pfam PF00538  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006309 apoptotic DNA fragmentation
Biological Process GO:0006342 chromatin silencing
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0031936 negative regulation of chromatin silencing
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0016584 nucleosome positioning
Biological Process GO:2000679 positive regulation of transcription regulatory region DNA binding
Biological Process GO:0006355 regulation of transcription, DNA-templated
molecular function GO:0003680 AT DNA binding
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0031492 nucleosomal DNA binding
molecular function GO:0003723 RNA binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0005794 Golgi apparatus
cellular component GO:0042025 host cell nucleus
cellular component GO:0016604 nuclear body
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005719 nuclear euchromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0000786 nucleosome
cellular component GO:0005634 nucleus
cellular component GO:0017053 transcription repressor complex
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-140342 Apoptosis induced DNA fragmentation
R-HSA-2262752 Cellular responses to stress
R-HSA-2559583 Cellular Senescence
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-5357801 Programmed Cell Death
R-HSA-75153 Apoptotic execution phase
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0023283 BXGD001629 Leishmaniasis, Cutaneous Infections; Skin and Connective Tissue Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026998 BXGD001959 Acute Myeloid Leukemia, M1 Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0238190 BXGD004890 Inclusion Body Myositis (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0268135 BXGD005831 Xeroderma pigmentosum, group A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0338831 BXGD007216 Manic Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751713 BXGD010564 Inclusion Body Myopathy, Sporadic Musculoskeletal Diseases; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1879321 BXGD016572 Acute Myeloid Leukemia (AML-M2) Neoplasms
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003196 Aripiprazole 448.39
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein