adisease

Showing entry for Manic

General Disease Information
BXGD Id	BXGD007216
Disease Name	Manic
Disease CUI Id	C0338831
MeSH Codes	F03
Disease Class Name	Mental Disorders
Semantic Type	Mental or Behavioral Dysfunction
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14594	BXGT004073	Neurocan core protein	1463	reviewed	Extracellular structure
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O94759	BXGT005327	Transient receptor potential cation channel subfamily M member 2	7226	reviewed	Ion channel
O95864	BXGT005403	Acyl-CoA 6-desaturase	9415	reviewed
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P07305	BXGT006594	Histone H1.0	3005	reviewed	Nucleic acid binding
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P17516	BXGT008313	Aldo-keto reductase family 1 member C4	1109	reviewed	Enzyme
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18405	BXGT008400	3-oxo-5-alpha-steroid 4-dehydrogenase 1	6715	reviewed	Enzyme
P19404	BXGT008477	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	4729	reviewed
P19827	BXGT008523	Inter-alpha-trypsin inhibitor heavy chain H1	3697	reviewed	Enzyme modulator
P20472	BXGT008578	Parvalbumin alpha	5816	reviewed	Calcium-binding protein
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P21918	BXGT008708	D(1B) dopamine receptor	1816	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P23368	BXGT008856	NAD-dependent malic enzyme, mitochondrial	4200	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P42261	BXGT010293	Glutamate receptor 1	2890	reviewed	Ion channel
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48147	BXGT010620	Prolyl endopeptidase	5550	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49773	BXGT010741	Histidine triad nucleotide-binding protein 1	3094	reviewed	Enzyme
P49840	BXGT010749	Glycogen synthase kinase-3 alpha	2931	reviewed	Kinase
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P51114	BXGT010832	Fragile X mental retardation syndrome-related protein 1	8087	reviewed	Nucleic acid binding
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P60903	BXGT011339	Protein S100-A10	6281	reviewed	Calcium-binding protein
P78362	BXGT011839	SRSF protein kinase 2	6733	reviewed	Kinase
P78504	BXGT011844	Protein jagged-1	182	reviewed
Q01668	BXGT012605	Voltage-dependent L-type calcium channel subunit alpha-1D	776	reviewed	Ion channel
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q06520	BXGT012880	Bile salt sulfotransferase	6822	reviewed
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q08722	BXGT013002	Leukocyte surface antigen CD47	961	reviewed
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q13002	BXGT013303	Glutamate receptor ionotropic, kainate 2	2898	reviewed	Ion channel
Q13043	BXGT013307	Serine/threonine-protein kinase 4	6789	reviewed	Kinase
Q13541	BXGT013371	Eukaryotic translation initiation factor 4E-binding protein 1	1978	reviewed	Nucleic acid binding
Q13936	BXGT013404	Voltage-dependent L-type calcium channel subunit alpha-1C	775	reviewed	Ion channel
Q14416	BXGT013468	Metabotropic glutamate receptor 2	2912	reviewed	G-protein coupled receptor
Q15349	BXGT013558	Ribosomal protein S6 kinase alpha-2	6196	reviewed	Kinase
Q16620	BXGT013645	BDNF/NT-3 growth factors receptor	4915	reviewed	Kinase
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8NFD2	BXGT018559	Ankyrin repeat and protein kinase domain-containing protein 1	255239	reviewed	Kinase
Q96CW9	BXGT019634	Netrin-G2	84628	reviewed	Enzyme modulator
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96EN8	BXGT019649	Molybdenum cofactor sulfurase	55034	reviewed
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q96RR4	BXGT019734	Calcium/calmodulin-dependent protein kinase kinase 2	10645	reviewed	Kinase
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q9UJS0	BXGT021727	Calcium-binding mitochondrial carrier protein Aralar2	10165	reviewed	Transporter
Q9UQL6	BXGT021813	Histone deacetylase 5	10014	reviewed	Epigenetic regulator
Q9Y2I2	BXGT022236	Netrin-G1	22854	reviewed	Enzyme modulator
Q9UNS1	BXGT022882	Protein timeless homolog	8914	reviewed
Q9H694	BXGT024116	Protein bicaudal C homolog 1	80114	reviewed	Transporter

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}