Showing entry for Complement C1s subcomponent


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006932
Protein NameComplement C1s subcomponent
Uniport IdP09871
GeneC1S
Gene Id716
DomainCUB; FXa_inhibition; Sushi; Trypsin
Pfam PF00431   PF00084   PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006956 complement activation
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0045087 innate immune response
Biological Process GO:0030449 regulation of complement activation
molecular function GO:0005509 calcium ion binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004252 serine-type endopeptidase activity
cellular component GO:0072562 blood microparticle
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-166663 Initial triggering of complement
R-HSA-166786 Creation of C4 and C2 activators
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019243 BXGD001308 Angioedemas, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0030605 BXGD002248 Activated Partial Thromboplastin Time measurement
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0162154 BXGD003922 Atrophic scar Pathological Conditions, Signs and Symptoms
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0241074 BXGD005078 Hyperextensible skin
C0241181 BXGD005084 Fragile skin
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0266052 BXGD005614 Precocious exfoliation of primary tooth Stomatognathic Diseases
C0268347 BXGD005907 Ehlers-Danlos Syndrome, Type VIII Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C0349588 BXGD007933 Short stature
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0427460 BXGD008616 Red cell distribution width determination
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C1112433 BXGD011667 Thromboembolic stroke Cardiovascular Diseases
C1281901 BXGD012133 Fatty acid measurement
C1290511 BXGD012188 Anodontia of Permanent Dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1842774 BXGD014536 Hypermelanotic macule
C1855642 BXGD015519 Atrophy of alveolar ridges
C1862892 BXGD016142 Hereditary Angioedema Type II Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2717905 BXGD017517 Hereditary Angioedema Types I and II Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C2717906 BXGD017518 Hereditary Angioedema Type I Skin and Connective Tissue Diseases; Immune System Diseases; Cardiovascular Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2985280 BXGD018223 Blood Protein Measurement
C3151078 BXGD018387 Complement Component C1s Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3553764 BXGD019187 Joint hyperflexibility
C4025213 BXGD021594 Abnormality of complement system
C4310681 BXGD022622 EHLERS-DANLOS SYNDROME, PERIODONTAL TYPE, 2
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
BXGC0018397 beta-1,4-mannan 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein