adisease

Showing entry for Hashimoto Disease

General Disease Information
BXGD Id	BXGD009721
Disease Name	Hashimoto Disease
Disease CUI Id	C0677607
MeSH Codes	C19
Disease Class Name	Endocrine System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000818 HP:0002715
Human Phenotype Ontology Term	Abnormality of the endocrine system; Abnormality of the immune system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O43524	BXGT004599	Forkhead box protein O3	2309	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O75369	BXGT005119	Filamin-B	2317	reviewed
O95178	BXGT005357	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	4708	reviewed
O95256	BXGT005364	Interleukin-18 receptor accessory protein	8807	reviewed	Receptor
O95267	BXGT005368	RAS guanyl-releasing protein 1	10125	reviewed	Enzyme modulator
O95477	BXGT005383	Phospholipid-transporting ATPase ABCA1	19	reviewed	Transporter
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P00750	BXGT005642	Tissue-type plasminogen activator	5327	reviewed	Enzyme
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01308	BXGT005749	Insulin	3630	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01589	BXGT005773	Interleukin-2 receptor subunit alpha	3559	reviewed	Receptor
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02647	BXGT005908	Apolipoprotein A-I	335	reviewed
P02818	BXGT005969	Osteocalcin	632	reviewed
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P04183	BXGT006166	Thymidine kinase, cytosolic	7083	reviewed	Kinase
P04271	BXGT006177	Protein S100-B	6285	reviewed	Calcium-binding protein
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05109	BXGT006318	Protein S100-A8	6279	reviewed	Calcium-binding protein
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06126	BXGT006412	T-cell surface glycoprotein CD1a	909	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08575	BXGT006793	Receptor-type tyrosine-protein phosphatase C	5788	reviewed	Enzyme
P08887	BXGT006835	Interleukin-6 receptor subunit alpha	3570	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09871	BXGT006932	Complement C1s subcomponent	716	reviewed	Enzyme
P10144	BXGT007541	Granzyme B	3002	reviewed	Enzyme
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P10828	BXGT007624	Thyroid hormone receptor beta	7068	reviewed	Nuclear receptor
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P13501	BXGT007917	C-C motif chemokine 5	6352	reviewed	Signaling
P13631	BXGT007929	Retinoic acid receptor gamma	5916	reviewed	Nuclear receptor
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20338	BXGT008564	Ras-related protein Rab-4A	5867	reviewed
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P22352	BXGT008758	Glutathione peroxidase 3	2878	reviewed	Enzyme
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24666	BXGT008986	Low molecular weight phosphotyrosine protein phosphatase	52	reviewed
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25774	BXGT009066	Cathepsin S	1520	reviewed	Enzyme
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27707	BXGT009201	Deoxycytidine kinase	1633	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P29017	BXGT009305	T-cell surface glycoprotein CD1c	911	reviewed
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P33681	BXGT009739	T-lymphocyte activation antigen CD80	941	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P36639	BXGT009930	7,8-dihydro-8-oxoguanine triphosphatase	4521	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41182	BXGT010231	B-cell lymphoma 6 protein	604	reviewed
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49908	BXGT010760	Selenoprotein P	6414	reviewed	Extracellular structure
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P51451	BXGT010848	Tyrosine-protein kinase Blk	640	reviewed	Kinase
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P55040	BXGT011099	GTP-binding protein GEM	2669	reviewed
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P55157	BXGT011108	Microsomal triglyceride transfer protein large subunit	4547	reviewed	Transporter
P55899	BXGT011131	IgG receptor FcRn large subunit p51	2217	reviewed
P60033	BXGT011286	CD81 antigen	975	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P63146	BXGT011504	Ubiquitin-conjugating enzyme E2 B	7320	reviewed
P68036	BXGT011572	Ubiquitin-conjugating enzyme E2 L3	7332	reviewed	Enzyme
P78504	BXGT011844	Protein jagged-1	182	reviewed
P81172	BXGT011935	Hepcidin	57817	reviewed
Q02156	BXGT012639	Protein kinase C epsilon type	5581	reviewed	Kinase
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q07889	BXGT012946	Son of sevenless homolog 1	6654	reviewed	Enzyme modulator
Q09428	BXGT013036	ATP-binding cassette sub-family C member 8	6833	reviewed	Transporter
Q13478	BXGT013362	Interleukin-18 receptor 1	8809	reviewed	Receptor
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14393	BXGT013466	Growth arrest-specific protein 6	2621	reviewed	Extracellular structure
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q495A1	BXGT014764	T-cell immunoreceptor with Ig and ITIM domains	201633	reviewed
Q5JPH6	BXGT015456	Probable glutamate--tRNA ligase, mitochondrial	124454	reviewed	Enzyme
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6ZMJ4	BXGT016628	Interleukin-34	146433	reviewed
Q8IU54	BXGT018331	Interferon lambda-1	282618	reviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q96AZ6	BXGT019621	Interferon-stimulated gene 20 kDa protein	3669	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96F46	BXGT019656	Interleukin-17 receptor A	23765	reviewed
Q96J66	BXGT019680	ATP-binding cassette sub-family C member 11	85320	reviewed	Transporter
Q96PD4	BXGT019705	Interleukin-17F	112744	reviewed
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q9BQE4	BXGT020110	Selenoprotein S	55829	reviewed
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZX6	BXGT020428	Interleukin-22	50616	reviewed
Q9H015	BXGT020432	Solute carrier family 22 member 4	6583	reviewed	Transporter
Q9HBE5	BXGT020518	Interleukin-21 receptor	50615	reviewed	Receptor
Q9NR12	BXGT021174	PDZ and LIM domain protein 7	9260	reviewed	Cellular structure
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UBK8	BXGT021655	Methionine synthase reductase	4552	reviewed
Q9UKV8	BXGT021752	Protein argonaute-2	27161	reviewed
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q92911	BXGT022650	Sodium/iodide cotransporter	6528	reviewed	Transporter
Q92482	BXGT022676	Aquaporin-3	360	reviewed	Ion channel
P31994	BXGT023298	Low affinity immunoglobulin gamma Fc region receptor II-b	2213	reviewed	Cell adhesion
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q13635	BXGT024910	Protein patched homolog 1	5727	reviewed
Q96SD1	BXGT025929	Protein artemis	64421	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}