Showing entry for Histone H1.4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007566
Protein NameHistone H1.4
Uniport IdP10412
GeneH1-4
Gene Id3008
DomainLinker_histone
Pfam PF00538  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030261 chromosome condensation
Biological Process GO:0098532 histone H3-K27 trimethylation
Biological Process GO:0080182 histone H3-K4 trimethylation
Biological Process GO:0031936 negative regulation of chromatin silencing
Biological Process GO:0045910 negative regulation of DNA recombination
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0016584 nucleosome positioning
Biological Process GO:0006355 regulation of transcription, DNA-templated
molecular function GO:0043531 ADP binding
molecular function GO:0016208 AMP binding
molecular function GO:0005524 ATP binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0032564 dATP binding
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0005525 GTP binding
molecular function GO:0031492 nucleosomal DNA binding
molecular function GO:0003723 RNA binding
cellular component GO:0042025 host cell nucleus
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005719 nuclear euchromatin
cellular component GO:0005720 nuclear heterochromatin
cellular component GO:0000788 nuclear nucleosome
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-140342 Apoptosis induced DNA fragmentation
R-HSA-2262752 Cellular responses to stress
R-HSA-2559583 Cellular Senescence
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
R-HSA-5357801 Programmed Cell Death
R-HSA-75153 Apoptotic execution phase
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0004106 BXGD000254 Astigmatism Eye Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027960 BXGD002062 Nevus Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221369 BXGD004453 Acquired Camptodactyly
C0231341 BXGD004492 Premature aging syndrome Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0345392 BXGD007732 Congenital kyphoscoliosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0545053 BXGD009323 Advanced bone age
C0557874 BXGD009444 Global developmental delay
C0575158 BXGD009515 Kyphoscoliosis deformity of spine Musculoskeletal Diseases
C0600033 BXGD009682 Acquired Kyphoscoliosis Musculoskeletal Diseases
C0685409 BXGD009810 Congenital Camptodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1866231 BXGD016388 Full cheeks
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2986703 BXGD018240 Overgrowth Syndrome Pathological Conditions, Signs and Symptoms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021107 BXGD020557 Non-obstructive azoospermia Male Urogenital Diseases
C4479637 BXGD022944 RAHMAN SYNDROME
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein