Showing entry for Developmental Disabilities


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD000518
Disease NameDevelopmental Disabilities
Disease CUI IdC0008073
MeSH Codes F03  
Disease Class NameMental Disorders
Semantic TypeMental or Behavioral Dysfunction
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00151 BXGT003885 PDZ and LIM domain protein 1 9124 reviewed Cellular structure
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00429 BXGT003919 Dynamin-1-like protein 10059 reviewed Enzyme modulator
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta 2563 reviewed Ion channel
O14773 BXGT004096 Tripeptidyl-peptidase 1 1200 reviewed Enzyme
O15119 BXGT004128 T-box transcription factor TBX3 6926 reviewed Transcription factor
O15247 BXGT004142 Chloride intracellular channel protein 2 1193 reviewed Ion channel
O15305 BXGT004152 Phosphomannomutase 2 5373 reviewed Enzyme
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P07438 BXGT006625 Metallothionein-1B 4490 reviewed
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P10070 BXGT007534 Zinc finger protein GLI2 2736 reviewed
P10276 BXGT007553 Retinoic acid receptor alpha 5914 reviewed Nuclear receptor
P10412 BXGT007566 Histone H1.4 3008 reviewed Nucleic acid binding
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11233 BXGT007678 Ras-related protein Ral-A 5898 reviewed Enzyme modulator
P13637 BXGT007933 Sodium/potassium-transporting ATPase subunit alpha-3 478 reviewed Transporter
P13647 BXGT007937 Keratin, type II cytoskeletal 5 3852 reviewed
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P14550 BXGT008019 Aldo-keto reductase family 1 member A1 10327 reviewed Enzyme
P14679 BXGT008039 Tyrosinase 7299 reviewed Enzyme
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15328 BXGT008108 Folate receptor alpha 2348 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18089 BXGT008379 Alpha-2B adrenergic receptor 151 reviewed G-protein coupled receptor
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21583 BXGT008667 Kit ligand 4254 reviewed
P21675 BXGT008678 Transcription initiation factor TFIID subunit 1 6872 reviewed Kinase
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P22681 BXGT008795 E3 ubiquitin-protein ligase CBL 867 reviewed Enzyme
P23470 BXGT008872 Receptor-type tyrosine-protein phosphatase gamma 5793 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29033 BXGT009308 Gap junction beta-2 protein 2706 reviewed Cell-cell junction
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P30566 BXGT009446 Adenylosuccinate lyase 158 reviewed Enzyme
P31391 BXGT009535 Somatostatin receptor type 4 6754 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35348 BXGT009814 Alpha-1A adrenergic receptor 148 reviewed G-protein coupled receptor
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36507 BXGT009923 Dual specificity mitogen-activated protein kinase kinase 2 5605 reviewed Kinase
P41182 BXGT010231 B-cell lymphoma 6 protein 604 reviewed
P41227 BXGT010238 N-alpha-acetyltransferase 10 8260 reviewed Enzyme
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46939 BXGT010555 Utrophin 7402 reviewed
P48029 BXGT010606 Sodium- and chloride-dependent creatine transporter 1 6535 reviewed Transporter
P48051 BXGT010611 G protein-activated inward rectifier potassium channel 2 3763 reviewed Ion channel
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P48740 BXGT010659 Mannan-binding lectin serine protease 1 5648 reviewed Enzyme
P49336 BXGT010697 Cyclin-dependent kinase 8 1024 reviewed Kinase
P50416 BXGT010797 Carnitine O-palmitoyltransferase 1, liver isoform 1374 reviewed Enzyme
P50897 BXGT010823 Palmitoyl-protein thioesterase 1 5538 reviewed Enzyme
P51787 BXGT010889 Potassium voltage-gated channel subfamily KQT member 1 3784 reviewed Ion channel
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55157 BXGT011108 Microsomal triglyceride transfer protein large subunit 4547 reviewed Transporter
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P62266 BXGT011416 40S ribosomal protein S23 6228 reviewed Nucleic acid binding
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P68400 BXGT011599 Casein kinase II subunit alpha 1457 reviewed Kinase
P78504 BXGT011844 Protein jagged-1 182 reviewed
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q01105 BXGT012569 Protein SET 6418 reviewed Enzyme modulator
Q01453 BXGT012588 Peripheral myelin protein 22 5376 reviewed Cellular structure
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q04771 BXGT012783 Activin receptor type-1 90 reviewed Kinase
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q08499 BXGT012988 cAMP-specific 3',5'-cyclic phosphodiesterase 4D 5144 reviewed
Q12756 BXGT013261 Kinesin-like protein KIF1A 547 reviewed Cellular structure
Q12791 BXGT013264 Calcium-activated potassium channel subunit alpha-1 3778 reviewed Ion channel
Q12882 BXGT013276 Dihydropyrimidine dehydrogenase [NADP(+)] 1806 reviewed Enzyme
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B 2904 reviewed Ion channel
Q13467 BXGT013358 Frizzled-5 7855 reviewed G-protein coupled receptor
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q14003 BXGT013434 Potassium voltage-gated channel subfamily C member 3 3748 reviewed Ion channel
Q14004 BXGT013435 Cyclin-dependent kinase 13 8621 reviewed Kinase
Q14232 BXGT013457 Translation initiation factor eIF-2B subunit alpha 1967 reviewed
Q14527 BXGT013479 Helicase-like transcription factor 6596 reviewed
Q14643 BXGT013493 Inositol 1,4,5-trisphosphate receptor type 1 3708 reviewed Ion channel
Q14671 BXGT013496 Pumilio homolog 1 9698 reviewed Nucleic acid binding
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q14839 BXGT013509 Chromodomain-helicase-DNA-binding protein 4 1108 reviewed
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15465 BXGT013573 Sonic hedgehog protein 6469 reviewed
Q16620 BXGT013645 BDNF/NT-3 growth factors receptor 4915 reviewed Kinase
Q5HYI8 BXGT015421 Rab-like protein 3 285282 reviewed
Q6XUX3 BXGT016612 Dual serine/threonine and tyrosine protein kinase 25778 reviewed Kinase
Q7LBC6 BXGT016998 Lysine-specific demethylase 3B 51780 reviewed Epigenetic regulator
Q8NFD5 BXGT018560 AT-rich interactive domain-containing protein 1B 57492 reviewed
Q8TD30 BXGT018805 Alanine aminotransferase 2 84706 reviewed Enzyme
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92979 BXGT019402 Ribosomal RNA small subunit methyltransferase NEP1 10436 reviewed Nucleic acid binding
Q969I3 BXGT019609 Glycine N-acyltransferase-like protein 1 92292 reviewed
Q96T60 BXGT019745 Bifunctional polynucleotide phosphatase/kinase 11284 reviewed
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha 6326 reviewed Ion channel
Q99593 BXGT019939 T-box transcription factor TBX5 6910 reviewed Transcription factor
Q9BWP8 BXGT020153 Collectin-11 78989 reviewed Surfactant
Q9BXW4 BXGT020176 Microtubule-associated proteins 1A/1B light chain 3C 440738 reviewed
Q9GZZ9 BXGT020430 Ubiquitin-like modifier-activating enzyme 5 79876 reviewed Enzyme
Q9H9B1 BXGT020501 Histone-lysine N-methyltransferase EHMT1 79813 reviewed Epigenetic regulator
Q9NPC2 BXGT021150 Potassium channel subfamily K member 9 51305 reviewed Ion channel
Q9NRR6 BXGT021193 Phosphatidylinositol polyphosphate 5-phosphatase type IV 56623 reviewed
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase 1717 reviewed Enzyme
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B 10765 reviewed Epigenetic regulator
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UHX1 BXGT021707 Poly(U)-binding-splicing factor PUF60 22827 reviewed
Q9UIK4 BXGT021720 Death-associated protein kinase 2 23604 reviewed Kinase
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UPZ9 BXGT021804 Serine/threonine-protein kinase ICK 22858 reviewed Kinase
Q9Y243 BXGT022214 RAC-gamma serine/threonine-protein kinase 10000 reviewed Kinase
Q9Y2H9 BXGT022234 Microtubule-associated serine/threonine-protein kinase 1 22983 reviewed Kinase
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
Q9Y6K9 BXGT022333 NF-kappa-B essential modulator 8517 reviewed Kinase
Q15878 BXGT022659 Voltage-dependent R-type calcium channel subunit alpha-1E 777 reviewed Ion channel
Q7Z624 BXGT022792 Calmodulin-lysine N-methyltransferase 79823 reviewed
Q5FWF4 BXGT023211 DNA annealing helicase and endonuclease ZRANB3 84083 reviewed
P16615 BXGT023653 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 488 reviewed Transporter
Q15583 BXGT024027 Homeobox protein TGIF1 7050 reviewed Enzyme
Q9H0W8 BXGT024746 Protein SMG9 56006 reviewed
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
O43583 BXGT024866 Density-regulated protein 8562 reviewed Enzyme
A6NHR9 BXGT024875 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 23347 reviewed
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
P27918 BXGT025485 Properdin 5199 reviewed
Q96DA2 BXGT025522 Ras-related protein Rab-39B 116442 reviewed
Q05086 BXGT025648 Ubiquitin-protein ligase E3A 7337 reviewed
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
P19532 BXGT026110 Transcription factor E3 7030 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease