Showing entry for Premature aging syndrome


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004492
Disease NamePremature aging syndrome
Disease CUI IdC0231341
MeSH Codes C23  
Disease Class NamePathological Conditions, Signs and Symptoms
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O14980 BXGT004119 Exportin-1 7514 reviewed Receptor
O43464 BXGT004595 Serine protease HTRA2, mitochondrial 27429 reviewed
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O75844 BXGT005156 CAAX prenyl protease 1 homolog 10269 reviewed Enzyme
O94762 BXGT005329 ATP-dependent DNA helicase Q5 9400 reviewed Enzyme
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05230 BXGT006344 Fibroblast growth factor 1 2246 reviewed Signaling
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P08195 BXGT006745 4F2 cell-surface antigen heavy chain 6520 reviewed Transporter
P08236 BXGT006752 Beta-glucuronidase 2990 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10412 BXGT007566 Histone H1.4 3008 reviewed Nucleic acid binding
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15941 BXGT008176 Mucin-1 4582 reviewed
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P32322 BXGT009624 Pyrroline-5-carboxylate reductase 1, mitochondrial 5831 reviewed
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P42575 BXGT010318 Caspase-2 835 reviewed Enzyme
P45381 BXGT010460 Aspartoacylase 443 reviewed
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P54132 BXGT011032 Bloom syndrome protein 641 reviewed
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P78344 BXGT011835 Eukaryotic translation initiation factor 4 gamma 2 1982 reviewed Nucleic acid binding
Q00059 BXGT012512 Transcription factor A, mitochondrial 7019 reviewed
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q03468 BXGT012716 DNA excision repair protein ERCC-6 2074 reviewed
Q04760 BXGT012782 Lactoylglutathione lyase 2739 reviewed
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q09028 BXGT013025 Histone-binding protein RBBP4 5928 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13472 BXGT013360 DNA topoisomerase 3-alpha 7156 reviewed Enzyme
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase 7486 reviewed Enzyme
Q15554 BXGT013577 Telomeric repeat-binding factor 2 7014 reviewed
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q7L5Y1 BXGT016996 Mitochondrial enolase superfamily member 1 55556 reviewed Enzyme
Q7Z2E3 BXGT017246 Aprataxin 54840 reviewed Nucleic acid binding
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q8N6T7 BXGT018525 NAD-dependent protein deacetylase sirtuin-6 51548 reviewed Epigenetic regulator
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9GZR1 BXGT020423 Sentrin-specific protease 6 26054 reviewed Enzyme
Q9Y618 BXGT022315 Nuclear receptor corepressor 2 9612 reviewed Transcription factor
Q9Y6K9 BXGT022333 NF-kappa-B essential modulator 8517 reviewed Kinase
Q59FF6 BXGT023693 Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant 2074 unreviewed
Q9HAU4 BXGT024040 E3 ubiquitin-protein ligase SMURF2 64750 reviewed Enzyme
Q9H040 BXGT024831 SprT-like domain-containing protein Spartan 83932 reviewed
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
Q96MS0 BXGT025241 Roundabout homolog 3 64221 reviewed Receptor
Q9UKU9 BXGT025985 Angiopoietin-related protein 2 23452 reviewed Signaling
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease