Showing entry for 5-aminolevulinate synthase, nonspecific, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007886
Protein Name5-aminolevulinate synthase, nonspecific, mitochondrial
Uniport IdP13196
GeneALAS1
Gene Id211
DomainAminotran_1_2; Preseq_ALAS
Pfam PF00155   PF09029  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00260 Glycine, serine and threonine metabolism
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00860 Porphyrin and chlorophyll metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0048821 erythrocyte development
Biological Process GO:0006783 heme biosynthetic process
Biological Process GO:0042541 hemoglobin biosynthetic process
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0006782 protoporphyrinogen IX biosynthetic process
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0001666 response to hypoxia
molecular function GO:0003870 5-aminolevulinate synthase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0030170 pyridoxal phosphate binding
cellular component GO:0005829 cytosol
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-189445 Metabolism of porphyrins
R-HSA-189451 Heme biosynthesis
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002896 BXGD000153 Sideroblastic anemia Hemic and Lymphatic Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0032708 BXGD002368 Disorders of Porphyrin Metabolism Nutritional and Metabolic Diseases
C0035410 BXGD002546 Rhabdomyolysis Musculoskeletal Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0162530 BXGD003949 Porphyria, Erythropoietic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162531 BXGD003950 Hereditary Coproporphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162532 BXGD003951 Variegate Porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0162565 BXGD003957 Acute intermittent porphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162568 BXGD003959 Erythropoietic Protoporphyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C3149631 BXGD018283 MELORHEOSTOSIS, ISOLATED
C3203509 BXGD018562 Neuropsychiatric syndrome
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein