Showing entry for Liver Failure, Acute


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD003956
Disease NameLiver Failure, Acute
Disease CUI IdC0162557
MeSH Codes C06  
Disease Class NameDigestive System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0025031  
Human Phenotype Ontology TermAbnormality of the digestive system
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14763 BXGT004093 Tumor necrosis factor receptor superfamily member 10B 8795 reviewed
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O15540 BXGT004178 Fatty acid-binding protein, brain 2173 reviewed
O15553 BXGT004181 Pyrin 4210 reviewed
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 6885 reviewed Kinase
O43521 BXGT004598 Bcl-2-like protein 11 10018 reviewed
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O75015 BXGT005095 Low affinity immunoglobulin gamma Fc region receptor III-B 2215 reviewed Cell adhesion
O75880 BXGT005158 Protein SCO1 homolog, mitochondrial 6341 reviewed Enzyme
P00480 BXGT005551 Ornithine carbamoyltransferase, mitochondrial 5009 reviewed
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P01008 BXGT005713 Antithrombin-III 462 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01215 BXGT005743 Glycoprotein hormones alpha chain 1081 reviewed
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01574 BXGT005768 Interferon beta 3456 reviewed
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P02671 BXGT005914 Fibrinogen alpha chain 2243 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02753 BXGT005945 Retinol-binding protein 4 5950 reviewed Transporter
P02765 BXGT005952 Alpha-2-HS-glycoprotein 197 reviewed Enzyme modulator
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02774 BXGT005959 Vitamin D-binding protein 2638 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05062 BXGT006305 Fructose-bisphosphate aldolase B 229 reviewed
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05177 BXGT006336 Cytochrome P450 1A2 1544 reviewed Enzyme
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05787 BXGT006385 Keratin, type II cytoskeletal 8 3856 reviewed
P06276 BXGT006430 Cholinesterase 590 reviewed
P07148 BXGT006559 Fatty acid-binding protein, liver 2168 reviewed
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08476 BXGT006774 Inhibin beta A chain 3624 reviewed Signaling
P08574 BXGT006792 Cytochrome c1, heme protein, mitochondrial 1537 reviewed
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08697 BXGT006815 Alpha-2-antiplasmin 5345 reviewed Enzyme modulator
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09467 BXGT006893 Fructose-1,6-bisphosphatase 1 2203 reviewed Enzyme
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10599 BXGT007583 Thioredoxin 7295 reviewed
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP 3309 reviewed
P11142 BXGT007658 Heat shock cognate 71 kDa protein 3312 reviewed
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 5292 reviewed Kinase
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P13196 BXGT007886 5-aminolevulinate synthase, nonspecific, mitochondrial 211 reviewed Enzyme
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P15309 BXGT008105 Prostatic acid phosphatase 55 reviewed Enzyme
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 7364 reviewed
P16930 BXGT008272 Fumarylacetoacetase 2184 reviewed
P18827 BXGT008427 Syndecan-1 6382 reviewed Extracellular structure
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P20810 BXGT008602 Calpastatin 831 reviewed
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21580 BXGT008666 Tumor necrosis factor alpha-induced protein 3 7128 reviewed Enzyme
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21817 BXGT008693 Ryanodine receptor 1 6261 reviewed Ion channel
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P25105 BXGT009021 Platelet-activating factor receptor 5724 reviewed G-protein coupled receptor
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30086 BXGT009400 Phosphatidylethanolamine-binding protein 1 5037 reviewed Enzyme modulator
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41235 BXGT010241 Hepatocyte nuclear factor 4-alpha 3172 reviewed Nuclear receptor
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P43652 BXGT010405 Afamin 173 reviewed Transporter
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48065 BXGT010617 Sodium- and chloride-dependent betaine transporter 6539 reviewed Transporter
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P55789 BXGT011126 FAD-linked sulfhydryl oxidase ALR 2671 reviewed Enzyme
P55957 BXGT011137 BH3-interacting domain death agonist 637 reviewed
P56192 BXGT011149 Methionine--tRNA ligase, cytoplasmic 4141 reviewed
P57764 BXGT011217 Gasdermin-D 79792 reviewed
P58004 BXGT011222 Sestrin-2 83667 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60903 BXGT011339 Protein S100-A10 6281 reviewed Calcium-binding protein
P78508 BXGT011845 ATP-sensitive inward rectifier potassium channel 10 3766 reviewed Ion channel
P80511 BXGT011914 Protein S100-A12 6283 reviewed Calcium-binding protein
P81172 BXGT011935 Hepcidin 57817 reviewed
P98066 BXGT012225 Tumor necrosis factor-inducible gene 6 protein 7130 reviewed
P98160 BXGT012228 Basement membrane-specific heparan sulfate proteoglycan core protein 3339 reviewed Enzyme modulator
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q10589 BXGT013203 Bone marrow stromal antigen 2 684 reviewed
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13427 BXGT013354 Peptidyl-prolyl cis-trans isomerase G 9360 reviewed
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13546 BXGT013372 Receptor-interacting serine/threonine-protein kinase 1 8737 reviewed Kinase
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S 779 reviewed Ion channel
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15493 BXGT013575 Regucalcin 9104 reviewed Enzyme
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16836 BXGT013679 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 3033 reviewed
Q16873 BXGT013684 Leukotriene C4 synthase 4056 reviewed Enzyme
Q2TU34 BXGT014223 Fructose-1,6-bisphosphatase 1 2203 unreviewed
Q5JAM2 BXGT015430 5-aminolevulinate synthase 211 unreviewed
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q7LG56 BXGT016999 Ribonucleoside-diphosphate reductase subunit M2 B 50484 reviewed Enzyme
Q86V86 BXGT017617 Serine/threonine-protein kinase pim-3 415116 reviewed
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 22933 reviewed Epigenetic regulator
Q92769 BXGT019370 Histone deacetylase 2 3066 reviewed Epigenetic regulator
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q96D42 BXGT019636 Hepatitis A virus cellular receptor 1 26762 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96J02 BXGT019679 E3 ubiquitin-protein ligase Itchy homolog 83737 reviewed Enzyme
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9H0A0 BXGT020434 RNA cytidine acetyltransferase 55226 reviewed
Q9H3M7 BXGT020462 Thioredoxin-interacting protein 10628 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9HC97 BXGT020527 G-protein coupled receptor 35 2859 reviewed G-protein coupled receptor
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9P2J5 BXGT021301 Leucine--tRNA ligase, cytoplasmic 51520 reviewed
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 10800 reviewed G-protein coupled receptor
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 5564 reviewed Kinase
Q9UNS1 BXGT022882 Protein timeless homolog 8914 reviewed
P35670 BXGT023695 Copper-transporting ATPase 2 540 reviewed Transporter
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
P08123 BXGT024477 Collagen alpha-2(I) chain 1278 reviewed
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
Q9BYE2 BXGT024631 Transmembrane protease serine 13 84000 reviewed Enzyme
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
Q96RD7 BXGT025890 Pannexin-1 24145 reviewed Ion channel
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease