Showing entry for Pulmonary Hypertension


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001425
Disease NamePulmonary Hypertension
Disease CUI IdC0020542
MeSH Codes C08  
Disease Class NameRespiratory Tract Diseases
Semantic TypePathologic Function
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00238 BXGT003900 Bone morphogenetic protein receptor type-1B 658 reviewed Kinase
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15392 BXGT004162 Baculoviral IAP repeat-containing protein 5 332 reviewed Enzyme modulator
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O60895 BXGT004907 Receptor activity-modifying protein 2 10266 reviewed Receptor
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02462 BXGT005881 Collagen alpha-1(IV) chain 1282 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02671 BXGT005914 Fibrinogen alpha chain 2243 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3156 reviewed
P04062 BXGT006140 Lysosomal acid glucosylceramidase 2629 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P04839 BXGT006273 Cytochrome b-245 heavy chain 1536 reviewed Ion channel
P05089 BXGT006310 Arginase-1 383 reviewed Enzyme
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10909 BXGT007630 Clusterin 1191 reviewed
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13196 BXGT007886 5-aminolevulinate synthase, nonspecific, mitochondrial 211 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13726 BXGT007950 Tissue factor 2152 reviewed Receptor
P14672 BXGT008037 Solute carrier family 2, facilitated glucose transporter member 4 6517 reviewed Transporter
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16109 BXGT008194 P-selectin 6403 reviewed
P18075 BXGT008375 Bone morphogenetic protein 7 655 reviewed Signaling
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19367 BXGT008476 Hexokinase-1 3098 reviewed Kinase
P20292 BXGT008561 Arachidonate 5-lipoxygenase-activating protein 241 reviewed Enzyme
P21452 BXGT008653 Substance-K receptor 6865 reviewed G-protein coupled receptor
P22460 BXGT008774 Potassium voltage-gated channel subfamily A member 5 3741 reviewed Ion channel
P24530 BXGT008975 Endothelin receptor type B 1910 reviewed G-protein coupled receptor
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P25103 BXGT009020 Substance-P receptor 6869 reviewed G-protein coupled receptor
P25705 BXGT009060 ATP synthase subunit alpha, mitochondrial 498 reviewed Transporter
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30101 BXGT009402 Protein disulfide-isomerase A3 2923 reviewed
P30411 BXGT009424 B2 bradykinin receptor 624 reviewed G-protein coupled receptor
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P34913 BXGT009770 Bifunctional epoxide hydrolase 2 2053 reviewed Enzyme
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37023 BXGT009953 Serine/threonine-protein kinase receptor R3 94 reviewed Kinase
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P41595 BXGT010267 5-hydroxytryptamine receptor 2B 3357 reviewed G-protein coupled receptor
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase 10135 reviewed Signaling
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P61586 BXGT011375 Transforming protein RhoA 387 reviewed Enzyme modulator
P78540 BXGT011848 Arginase-2, mitochondrial 384 reviewed Enzyme
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q07817 BXGT012941 Bcl-2-like protein 1 598 reviewed Signaling
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q12791 BXGT013264 Calcium-activated potassium channel subunit alpha-1 3778 reviewed Ion channel
Q12794 BXGT013265 Hyaluronidase-1 3373 reviewed Enzyme
Q13093 BXGT013310 Platelet-activating factor acetylhydrolase 7941 reviewed Enzyme
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13873 BXGT013398 Bone morphogenetic protein receptor type-2 659 reviewed Kinase
Q13976 BXGT013409 cGMP-dependent protein kinase 1 5592 reviewed Kinase
Q14432 BXGT013469 cGMP-inhibited 3',5'-cyclic phosphodiesterase A 5139 reviewed
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q16647 BXGT013648 Prostacyclin synthase 5740 reviewed
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q5JAM2 BXGT015430 5-aminolevulinate synthase 211 unreviewed
Q8IWA4 BXGT018353 Mitofusin-1 55669 reviewed Enzyme
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 2034 reviewed Transcription factor
Q9NPH5 BXGT021159 NADPH oxidase 4 50507 reviewed Enzyme
Q9NY59 BXGT021251 Sphingomyelin phosphodiesterase 3 55512 reviewed
Q9P2K8 BXGT021302 eIF-2-alpha kinase GCN2 440275 reviewed
Q9UQL6 BXGT021813 Histone deacetylase 5 10014 reviewed Epigenetic regulator
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 10800 reviewed G-protein coupled receptor
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P16284 BXGT022972 Platelet endothelial cell adhesion molecule 5175 reviewed Cell adhesion
Q9UK05 BXGT023094 Growth/differentiation factor 2 2658 reviewed Signaling
P17752 BXGT023118 Tryptophan 5-hydroxylase 1 7166 reviewed
P16615 BXGT023653 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 488 reviewed Transporter
O15198 BXGT024049 Mothers against decapentaplegic homolog 9 4093 reviewed Transcription factor
O95399 BXGT024237 Urotensin-2 10911 reviewed
O14649 BXGT025486 Potassium channel subfamily K member 3 3777 reviewed Ion channel
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease