Showing entry for Aspartate--tRNA ligase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008062
Protein NameAspartate--tRNA ligase, cytoplasmic
Uniport IdP14868
GeneDARS1
Gene Id1615
DomaintRNA-synt_2; tRNA_anti-codon
Pfam PF00152   PF01336  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006422 aspartyl-tRNA aminoacylation
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0006412 translation
Biological Process GO:0006418 tRNA aminoacylation for protein translation
molecular function GO:0004046 aminoacylase activity
molecular function GO:0004815 aspartate-tRNA ligase activity
molecular function GO:0005524 ATP binding
molecular function GO:0003723 RNA binding
cellular component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0034935 BXGD002497 Babinski Reflex
C0041296 BXGD002903 Tuberculosis Infections
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0200633 BXGD004040 Neutrophil count (procedure)
C0200637 BXGD004042 Monocyte count procedure
C0269269 BXGD006058 Inversion of nipple (disorder) Skin and Connective Tissue Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0748903 BXGD010206 spinal cord involvement
C0750880 BXGD010239 Monocyte count result
C1271100 BXGD012007 Lower limb spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1386048 BXGD012950 Intrauterine retardation
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836830 BXGD014165 Developmental regression Mental Disorders
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C1969084 BXGD016755 Pontocerebellar Hypoplasia Type 6 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1970180 BXGD016813 Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation Nutritional and Metabolic Diseases; Nervous System Diseases
C2677180 BXGD017366 Congenital microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3809008 BXGD019570 HYPOMYELINATION WITH BRAINSTEM AND SPINAL CORD INVOLVEMENT AND LEG SPASTICITY
C3894553 BXGD020038 response to simvastatin
C4021085 BXGD020544 Abnormality of brain morphology
C4025616 BXGD021697 CNS hypomyelination
C4553743 BXGD023548 Spasticity, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4755254 BXGD024087 Hypomyelination with brain stem and spinal cord involvement and leg spasticity
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0006186 L-Aspartic acid 133.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein