adisease

Showing entry for Leukodystrophy

General Disease Information
BXGD Id	BXGD001678
Disease Name	Leukodystrophy
Disease CUI Id	C0023520
MeSH Codes	C16 C18 C10
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00217	BXGT003898	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	4728	reviewed	Enzyme
O00483	BXGT003930	Cytochrome c oxidase subunit NDUFA4	4697	reviewed	Enzyme
O15239	BXGT004139	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	4694	reviewed
O43181	BXGT004576	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	4724	reviewed
O43676	BXGT004611	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	4709	reviewed
O43678	BXGT004613	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	4695	reviewed	Enzyme
O75251	BXGT005107	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	374291	reviewed
O75306	BXGT005108	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	4720	reviewed	Enzyme
O75380	BXGT005120	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	4726	reviewed	Enzyme
O75489	BXGT005131	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	4722	reviewed
O95169	BXGT005356	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	4714	reviewed	Enzyme
O95299	BXGT005372	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	4705	reviewed	Enzyme
O95831	BXGT005399	Apoptosis-inducing factor 1, mitochondrial	9131	reviewed	Enzyme
O96000	BXGT005412	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	4716	reviewed
P02462	BXGT005881	Collagen alpha-1(IV) chain	1282	reviewed
P03886	BXGT006108	NADH-ubiquinone oxidoreductase chain 1	4535	reviewed	Enzyme
P03891	BXGT006110	NADH-ubiquinone oxidoreductase chain 2	4536	reviewed
P03897	BXGT006111	NADH-ubiquinone oxidoreductase chain 3	4537	reviewed
P04004	BXGT006125	Vitronectin	7448	reviewed
P04054	BXGT006136	Phospholipase A2	5319	reviewed	Enzyme
P04350	BXGT006193	Tubulin beta-4A chain	10382	reviewed	Cellular structure
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07602	BXGT006646	Prosaposin	5660	reviewed
P07814	BXGT006680	Bifunctional glutamate/proline--tRNA ligase	2058	reviewed	Enzyme
P08034	BXGT006716	Gap junction beta-1 protein	2705	reviewed	Cell-cell junction
P08514	BXGT006781	Integrin alpha-IIb	3674	reviewed
P08559	BXGT006788	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	5160	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P14868	BXGT008062	Aspartate--tRNA ligase, cytoplasmic	1615	reviewed	Enzyme
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P19404	BXGT008477	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	4729	reviewed
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P19971	BXGT008537	Thymidine phosphorylase	1890	reviewed	Enzyme
P20132	BXGT008546	L-serine dehydratase/L-threonine deaminase	10993	reviewed	Enzyme
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P28331	BXGT009252	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	4719	reviewed	Enzyme
P30044	BXGT009395	Peroxiredoxin-5, mitochondrial	25824	reviewed
P30084	BXGT009398	Enoyl-CoA hydratase, mitochondrial	1892	reviewed	Enzyme
P31040	BXGT009503	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	6389	reviewed	Enzyme
P31327	BXGT009523	Carbamoyl-phosphate synthase [ammonia], mitochondrial	1373	reviewed	Enzyme
P36021	BXGT009893	Monocarboxylate transporter 8	6567	reviewed	Transporter
P45381	BXGT010460	Aspartoacylase	443	reviewed
P49411	BXGT010703	Elongation factor Tu, mitochondrial	7284	reviewed	Enzyme
P49821	BXGT010748	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	4723	reviewed
P54136	BXGT011033	Arginine--tRNA ligase, cytoplasmic	5917	reviewed
P54803	BXGT011082	Galactocerebrosidase	2581	reviewed
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P55265	BXGT011117	Double-stranded RNA-specific adenosine deaminase	103	reviewed	Enzyme
P56556	BXGT011179	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	4700	reviewed	Enzyme
P63104	BXGT011499	14-3-3 protein zeta/delta	7534	reviewed	Chaperone
P80404	BXGT011907	4-aminobutyrate aminotransferase, mitochondrial	18	reviewed	Enzyme
Q00796	BXGT012549	Sorbitol dehydrogenase	6652	reviewed	Enzyme
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q04446	BXGT012764	1,4-alpha-glucan-branching enzyme	2632	reviewed	Enzyme
Q12840	BXGT013269	Kinesin heavy chain isoform 5A	3798	reviewed	Cellular structure
Q13144	BXGT013317	Translation initiation factor eIF-2B subunit epsilon	8893	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q14118	BXGT013444	Dystroglycan	1605	reviewed	Receptor
Q14232	BXGT013457	Translation initiation factor eIF-2B subunit alpha	1967	reviewed
Q15046	BXGT013527	Lysine--tRNA ligase	3735	reviewed	Enzyme
Q15067	BXGT013532	Peroxisomal acyl-coenzyme A oxidase 1	51	reviewed	Enzyme
Q16795	BXGT013671	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	4704	reviewed	Enzyme
Q5JTZ9	BXGT015458	Alanine--tRNA ligase, mitochondrial	57505	reviewed	Nucleic acid binding
Q6PI48	BXGT016471	Aspartate--tRNA ligase, mitochondrial	55157	reviewed	Enzyme
Q86SX6	BXGT017601	Glutaredoxin-related protein 5, mitochondrial	51218	reviewed	Enzyme
Q86Y39	BXGT017632	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	126328	reviewed
Q8N183	BXGT018497	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2	91942	reviewed
Q8TCS8	BXGT018799	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	87178	reviewed	Enzyme
Q96C36	BXGT019631	Pyrroline-5-carboxylate reductase 2	29920	reviewed
Q96GD0	BXGT019665	Pyridoxal phosphate phosphatase	57026	reviewed	Enzyme
Q99720	BXGT019955	Sigma non-opioid intracellular receptor 1	10280	reviewed
Q9BU61	BXGT020131	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3	25915	reviewed
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NX14	BXGT021242	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	54539	reviewed	Enzyme
Q9P032	BXGT021286	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4	29078	reviewed
Q9P0J0	BXGT021287	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	51079	reviewed	Enzyme
Q9P2K8	BXGT021302	eIF-2-alpha kinase GCN2	440275	reviewed
Q9UI09	BXGT021710	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	55967	reviewed
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9Y234	BXGT022211	Lipoyltransferase 1, mitochondrial	51601	reviewed	Enzyme
Q9Y375	BXGT022253	Complex I intermediate-associated protein 30, mitochondrial	51103	reviewed
Q9Y3Z3	BXGT022268	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	25939	reviewed
Q9Y6M9	BXGT022336	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	4715	reviewed	Enzyme
Q96C86	BXGT022803	m7GpppX diphosphatase	28960	reviewed	Enzyme
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
P38646	BXGT024954	Stress-70 protein, mitochondrial	3313	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}