Showing entry for Ventricular Septal Defects


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001236
Disease NameVentricular Septal Defects
Disease CUI IdC0018818
MeSH Codes C16   C14  
Disease Class NameCongenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
Semantic TypeCongenital Abnormality
Human Phenotype Ontology Id HP:0001626  
Human Phenotype Ontology TermAbnormality of the cardiovascular system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00217 BXGT003898 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial 4728 reviewed Enzyme
O00459 BXGT003924 Phosphatidylinositol 3-kinase regulatory subunit beta 5296 reviewed Enzyme modulator
O00483 BXGT003930 Cytochrome c oxidase subunit NDUFA4 4697 reviewed Enzyme
O14770 BXGT004095 Homeobox protein Meis2 4212 reviewed Enzyme
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O14936 BXGT004114 Peripheral plasma membrane protein CASK 8573 reviewed Kinase
O15119 BXGT004128 T-box transcription factor TBX3 6926 reviewed Transcription factor
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O43175 BXGT004575 D-3-phosphoglycerate dehydrogenase 26227 reviewed Enzyme
O43181 BXGT004576 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 4724 reviewed
O43678 BXGT004613 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 4695 reviewed Enzyme
O75251 BXGT005107 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 374291 reviewed
O75306 BXGT005108 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 4720 reviewed Enzyme
O75369 BXGT005119 Filamin-B 2317 reviewed
O75385 BXGT005121 Serine/threonine-protein kinase ULK1 8408 reviewed Kinase
O75489 BXGT005131 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 4722 reviewed
O76039 BXGT005171 Cyclin-dependent kinase-like 5 6792 reviewed Kinase
O95299 BXGT005372 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 4705 reviewed Enzyme
O95644 BXGT005389 Nuclear factor of activated T-cells, cytoplasmic 1 4772 reviewed Transcription factor
O96028 BXGT005417 Histone-lysine N-methyltransferase NSD2 7468 reviewed Epigenetic regulator
P00439 BXGT005539 Phenylalanine-4-hydroxylase 5053 reviewed
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05141 BXGT006325 ADP/ATP translocase 2 292 reviewed Transporter
P05413 BXGT006355 Fatty acid-binding protein, heart 2170 reviewed
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P07947 BXGT006701 Tyrosine-protein kinase Yes 7525 reviewed Kinase
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08559 BXGT006788 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 5160 reviewed
P09884 BXGT006937 DNA polymerase alpha catalytic subunit 5422 reviewed
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P14868 BXGT008062 Aspartate--tRNA ligase, cytoplasmic 1615 reviewed Enzyme
P14921 BXGT008068 Protein C-ets-1 2113 reviewed Transcription factor
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15086 BXGT008078 Carboxypeptidase B 1360 reviewed Enzyme
P15289 BXGT008102 Arylsulfatase A 410 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P17252 BXGT008294 Protein kinase C alpha type 5578 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P19404 BXGT008477 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 4729 reviewed
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P24468 BXGT008969 COUP transcription factor 2 7026 reviewed Nuclear receptor
P25098 BXGT009015 Beta-adrenergic receptor kinase 1 156 reviewed Kinase
P28331 BXGT009252 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 4719 reviewed Enzyme
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29401 BXGT009344 Transketolase 7086 reviewed Enzyme
P30084 BXGT009398 Enoyl-CoA hydratase, mitochondrial 1892 reviewed Enzyme
P30279 BXGT009415 G1/S-specific cyclin-D2 894 reviewed Enzyme modulator
P30533 BXGT009434 Alpha-2-macroglobulin receptor-associated protein 4043 reviewed
P31040 BXGT009503 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 6389 reviewed Enzyme
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P33681 BXGT009739 T-lymphocyte activation antigen CD80 941 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35499 BXGT009839 Sodium channel protein type 4 subunit alpha 6329 reviewed Ion channel
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P41143 BXGT010223 Delta-type opioid receptor 4985 reviewed G-protein coupled receptor
P41227 BXGT010238 N-alpha-acetyltransferase 10 8260 reviewed Enzyme
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P48740 BXGT010659 Mannan-binding lectin serine protease 1 5648 reviewed Enzyme
P49748 BXGT010733 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 37 reviewed Enzyme
P49767 BXGT010739 Vascular endothelial growth factor C 7424 reviewed Signaling
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49821 BXGT010748 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 4723 reviewed
P50281 BXGT010788 Matrix metalloproteinase-14 4323 reviewed Enzyme
P50542 BXGT010808 Peroxisomal targeting signal 1 receptor 5830 reviewed Transporter
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 6197 reviewed Kinase
P52952 BXGT010966 Homeobox protein Nkx-2.5 1482 reviewed Transcription factor
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P57059 BXGT011210 Serine/threonine-protein kinase SIK1 150094 reviewed
P58400 BXGT011235 Neurexin-1-beta 9378 reviewed
P61978 BXGT011399 Heterogeneous nuclear ribonucleoprotein K 3190 reviewed Enzyme
P62993 BXGT011480 Growth factor receptor-bound protein 2 2885 reviewed
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P63165 BXGT011506 Small ubiquitin-related modifier 1 7341 reviewed
P78504 BXGT011844 Protein jagged-1 182 reviewed
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D 776 reviewed Ion channel
Q01974 BXGT012628 Tyrosine-protein kinase transmembrane receptor ROR2 4920 reviewed Kinase
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 5604 reviewed Kinase
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q07889 BXGT012946 Son of sevenless homolog 1 6654 reviewed Enzyme modulator
Q09470 BXGT013037 Potassium voltage-gated channel subfamily A member 1 3736 reviewed Ion channel
Q09472 BXGT013038 Histone acetyltransferase p300 2033 reviewed
Q10469 BXGT013200 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 4247 reviewed Enzyme
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q13705 BXGT013393 Activin receptor type-2B 93 reviewed Kinase
Q14004 BXGT013435 Cyclin-dependent kinase 13 8621 reviewed Kinase
Q14683 BXGT013500 Structural maintenance of chromosomes protein 1A 8243 reviewed
Q15029 BXGT013524 116 kDa U5 small nuclear ribonucleoprotein component 9343 reviewed Enzyme
Q15031 BXGT013525 Probable leucine--tRNA ligase, mitochondrial 23395 reviewed Enzyme
Q15233 BXGT013552 Non-POU domain-containing octamer-binding protein 4841 reviewed Nucleic acid binding
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q16288 BXGT013625 NT-3 growth factor receptor 4916 reviewed Kinase
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q16795 BXGT013671 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 4704 reviewed Enzyme
Q7Z3B3 BXGT017249 KAT8 regulatory NSL complex subunit 1 284058 reviewed
Q86YC2 BXGT017633 Partner and localizer of BRCA2 79728 reviewed
Q8N183 BXGT018497 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 91942 reviewed
Q8NFD5 BXGT018560 AT-rich interactive domain-containing protein 1B 57492 reviewed
Q8TD19 BXGT018804 Serine/threonine-protein kinase Nek9 91754 reviewed Kinase
Q8WVQ1 BXGT018996 Soluble calcium-activated nucleotidase 1 124583 reviewed
Q8WWY3 BXGT019006 U4/U6 small nuclear ribonucleoprotein Prp31 26121 reviewed Nucleic acid binding
Q92736 BXGT019367 Ryanodine receptor 2 6262 reviewed Ion channel
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92794 BXGT019375 Histone acetyltransferase KAT6A 7994 reviewed Enzyme
Q92963 BXGT019401 GTP-binding protein Rit1 6016 reviewed Enzyme modulator
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96T60 BXGT019745 Bifunctional polynucleotide phosphatase/kinase 11284 reviewed
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha 6326 reviewed Ion channel
Q99593 BXGT019939 T-box transcription factor TBX5 6910 reviewed Transcription factor
Q99707 BXGT019952 Methionine synthase 4548 reviewed
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO 79068 reviewed
Q9NX14 BXGT021242 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial 54539 reviewed Enzyme
Q9P0J0 BXGT021287 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 51079 reviewed Enzyme
Q9UBC3 BXGT021650 DNA (cytosine-5)-methyltransferase 3B 1789 reviewed
Q9UBK8 BXGT021655 Methionine synthase reductase 4552 reviewed
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase 1717 reviewed Enzyme
Q9UHX1 BXGT021707 Poly(U)-binding-splicing factor PUF60 22827 reviewed
Q9UI09 BXGT021710 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 55967 reviewed
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UPN9 BXGT021799 E3 ubiquitin-protein ligase TRIM33 51592 reviewed
Q9UQM7 BXGT021814 Calcium/calmodulin-dependent protein kinase type II subunit alpha 815 reviewed Kinase
Q9Y234 BXGT022211 Lipoyltransferase 1, mitochondrial 51601 reviewed Enzyme
Q9Y243 BXGT022214 RAC-gamma serine/threonine-protein kinase 10000 reviewed Kinase
Q01543 BXGT023137 Friend leukemia integration 1 transcription factor 2313 reviewed Transcription factor
Q99958 BXGT023732 Forkhead box protein C2 2303 reviewed Transcription factor
Q96L73 BXGT024676 Histone-lysine N-methyltransferase, H3 lysine-36 specific 64324 reviewed Epigenetic regulator
Q9H0W8 BXGT024746 Protein SMG9 56006 reviewed
P35250 BXGT025854 Replication factor C subunit 2 5982 reviewed Enzyme
Q9UQE7 BXGT025899 Structural maintenance of chromosomes protein 3 9126 reviewed
P09471 BXGT026153 Guanine nucleotide-binding protein G(o) subunit alpha 2775 reviewed Enzyme modulator
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease