Showing entry for Cytoplasmic protein NCK1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008219
Protein NameCytoplasmic protein NCK1
Uniport IdP16333
GeneNCK1
Gene Id4690
DomainSH2; SH3_1; SH3_9
Pfam PF00017   PF00018   PF14604  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04012 ErbB signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05130 Pathogenic Escherichia coli infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
Biological Process GO:0046627 negative regulation of insulin receptor signaling pathway
Biological Process GO:0033137 negative regulation of peptidyl-serine phosphorylation
Biological Process GO:1903898 negative regulation of PERK-mediated unfolded protein response
Biological Process GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Biological Process GO:0070262 peptidyl-serine dephosphorylation
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:1903676 positive regulation of cap-dependent translational initiation
Biological Process GO:1903679 positive regulation of cap-independent translational initiation
Biological Process GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0051707 response to other organism
Biological Process GO:0007172 signal complex assembly
Biological Process GO:0006930 substrate-dependent cell migration, cell extension
Biological Process GO:0042110 T cell activation
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0048010 vascular endothelial growth factor receptor signaling pathway
molecular function GO:0045296 cadherin binding
molecular function GO:0008093 cytoskeletal anchor activity
molecular function GO:0046875 ephrin receptor binding
molecular function GO:0071074 eukaryotic initiation factor eIF2 binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0004860 protein kinase inhibitor activity
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0030971 receptor tyrosine kinase binding
molecular function GO:0035591 signaling adaptor activity
molecular function GO:0005102 signaling receptor binding
molecular function GO:0030159 signaling receptor complex adaptor activity
cellular component GO:0005911 cell-cell junction
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0000164 protein phosphatase type 1 complex
cellular component GO:0005840 ribosome
cellular component GO:0012506 vesicle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-1500931 Cell-Cell communication
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-186763 Downstream signal transduction
R-HSA-186797 Signaling by PDGF
R-HSA-194138 Signaling by VEGF
R-HSA-194315 Signaling by Rho GTPases
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-195258 RHO GTPase Effectors
R-HSA-202403 TCR signaling
R-HSA-202433 Generation of second messenger molecules
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-373752 Netrin-1 signaling
R-HSA-373752 Netrin-1 signaling
R-HSA-373753 Nephrin family interactions
R-HSA-376176 Signaling by ROBO receptors
R-HSA-418885 DCC mediated attractive signaling
R-HSA-418885 DCC mediated attractive signaling
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-428540 Activation of RAC1
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9658195 Leishmania infection
R-HSA-9658195 Leishmania infection
R-HSA-9664407 Parasite infection
R-HSA-9664407 Parasite infection
R-HSA-9664417 Leishmania phagocytosis
R-HSA-9664417 Leishmania phagocytosis
R-HSA-9664422 FCGR3A-mediated phagocytosis
R-HSA-9664422 FCGR3A-mediated phagocytosis
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001925 BXGD000090 Albuminuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005845 BXGD000341 Blood urea nitrogen measurement
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0855095 BXGD011071 Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1512433 BXGD013191 Cervical high grade squamous intraepithelial lesion Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049993 BXGD021957 Aristolochic Acid Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006109 2-Aminoquinoline 144.17
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein