Showing entry for Heat shock 70 kDa protein 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008279
Protein NameHeat shock 70 kDa protein 6
Uniport IdP17066
GeneHSPA6
Gene Id3310
DomainHSP70
Pfam PF00012  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.9 Aging hsa04213 Longevity regulating pathway - multiple species
5. Organismal Systems 5.1 Immune system hsa04612 Antigen processing and presentation
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05134 Legionellosis
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05145 Toxoplasmosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0034620 cellular response to unfolded protein
Biological Process GO:0051085 chaperone cofactor-dependent protein refolding
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0042026 protein refolding
Biological Process GO:0006986 response to unfolded protein
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0016887 ATPase activity
molecular function GO:0005524 ATP binding
molecular function GO:0019899 enzyme binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0051787 misfolded protein binding
molecular function GO:0044183 protein folding chaperone
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0051082 unfolded protein binding
cellular component GO:0072562 blood microparticle
cellular component GO:0005814 centriole
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2262752 Cellular responses to stress
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-6798695 Neutrophil degranulation
R-HSA-8953897 Cellular responses to external stimuli
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0087031 BXGD003319 Juvenile-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0151971 BXGD003512 Primary ulcer of intestine Digestive System Diseases
C0302142 BXGD006831 Deformity Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0333523 BXGD006959 Deep caries Pathological Conditions, Signs and Symptoms; Stomatognathic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2718001 BXGD017521 Protein Misfolding Disorders Nutritional and Metabolic Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714758 BXGD019431 Juvenile psoriatic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3888534 BXGD019978 Gastrointestinal wall thickening
C4552091 BXGD023485 Polyarthritis, Juvenile, Rheumatoid Factor Negative Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4704862 BXGD023681 Polyarthritis, Juvenile, Rheumatoid Factor Positive Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0015284 2,3-dihydro-3beta-O-sulfate withaferin A 568.23
BXGC0021676 Withaferin A 470.27
BXGC0022098 Withanolide A 470.27
BXGC0035824 Viscosalactone B 488.28
BXGC0038100 Dihydrowithaferin A 472.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein