Showing entry for Glycine receptor subunit alpha-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008865
Protein NameGlycine receptor subunit alpha-2
Uniport IdP23416
GeneGLRA2
Gene Id2742
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0071361 cellular response to ethanol
Biological Process GO:0071294 cellular response to zinc ion
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0050877 nervous system process
Biological Process GO:0007218 neuropeptide signaling pathway
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0043200 response to amino acid
Biological Process GO:0007165 signal transduction
Biological Process GO:0060012 synaptic transmission, glycinergic
molecular function GO:0016934 extracellularly glycine-gated chloride channel activity
molecular function GO:0016594 glycine binding
molecular function GO:0022852 glycine-gated chloride ion channel activity
molecular function GO:0046872 metal ion binding
molecular function GO:0030594 neurotransmitter receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
cellular component GO:0034707 chloride channel complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0733682 BXGD009968 Hypophosphatemic Rickets, X-Linked Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000434 Ethanol 46.07
BXGC0002374 Taurine 125.15
BXGC0008379 Ginkgolide B 424.4
BXGC0008380 Ginkgolide A 408.4
BXGC0016417 Picrotoxin 310.11
BXGC0039213 Ginkgolide M 424.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein