adisease

Showing entry for Rett Syndrome

General Disease Information
BXGD Id	BXGD002544
Disease Name	Rett Syndrome
Disease CUI Id	C0035372
MeSH Codes	C16 C10
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:150
Disease Ontology Class Name	disease of mental health
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00757	BXGT003946	Fructose-1,6-bisphosphatase isozyme 2	8789	reviewed	Enzyme
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	2563	reviewed	Ion channel
O14936	BXGT004114	Peripheral plasma membrane protein CASK	8573	reviewed	Kinase
O75311	BXGT005109	Glycine receptor subunit alpha-3	8001	reviewed	Ion channel
O75628	BXGT005140	GTP-binding protein REM 1	28954	reviewed
O75899	BXGT005161	Gamma-aminobutyric acid type B receptor subunit 2	9568	reviewed	G-protein coupled receptor
O76039	BXGT005171	Cyclin-dependent kinase-like 5	6792	reviewed	Kinase
O95278	BXGT005370	Laforin	7957	reviewed
P00367	BXGT005517	Glutamate dehydrogenase 1, mitochondrial	2746	reviewed	Enzyme
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	3251	reviewed	Enzyme
P01130	BXGT005735	Low-density lipoprotein receptor	3949	reviewed
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02746	BXGT005938	Complement C1q subcomponent subunit B	713	reviewed
P02747	BXGT005939	Complement C1q subcomponent subunit C	714	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04731	BXGT006251	Metallothionein-1A	4489	reviewed
P06730	BXGT006487	Eukaryotic translation initiation factor 4E	1977	reviewed	Nucleic acid binding
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08620	BXGT006800	Fibroblast growth factor 4	2249	reviewed	Signaling
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09467	BXGT006893	Fructose-1,6-bisphosphatase 1	2203	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10909	BXGT007630	Clusterin	1191	reviewed
P11137	BXGT007656	Microtubule-associated protein 2	4133	reviewed
P12235	BXGT007774	ADP/ATP translocase 1	291	reviewed	Transporter
P14207	BXGT007993	Folate receptor beta	2350	reviewed
P15328	BXGT008108	Folate receptor alpha	2348	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16050	BXGT008184	Arachidonate 15-lipoxygenase	246	reviewed	Enzyme
P16220	BXGT008206	Cyclic AMP-responsive element-binding protein 1	1385	reviewed
P16389	BXGT008221	Potassium voltage-gated channel subfamily A member 2	3737	reviewed	Ion channel
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	5770	reviewed
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P22314	BXGT008755	Ubiquitin-like modifier-activating enzyme 1	7317	reviewed	Enzyme
P23416	BXGT008865	Glycine receptor subunit alpha-2	2742	reviewed	Ion channel
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P26358	BXGT009104	DNA (cytosine-5)-methyltransferase 1	1786	reviewed	Epigenetic regulator
P27815	BXGT009208	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	5141	reviewed
P28329	BXGT009251	Choline O-acetyltransferase	1103	reviewed	Enzyme
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	2562	reviewed	Ion channel
P29074	BXGT009313	Tyrosine-protein phosphatase non-receptor type 4	5775	reviewed
P30626	BXGT009450	Sorcin	6717	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32004	BXGT009594	Neural cell adhesion molecule L1	3897	reviewed
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	2556	reviewed	Ion channel
P34969	BXGT009777	5-hydroxytryptamine receptor 7	3363	reviewed	G-protein coupled receptor
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35498	BXGT009838	Sodium channel protein type 1 subunit alpha	6323	reviewed	Ion channel
P40933	BXGT010209	Interleukin-15	3600	reviewed
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P42262	BXGT010294	Glutamate receptor 2	2891	reviewed	Ion channel
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P48029	BXGT010606	Sodium- and chloride-dependent creatine transporter 1	6535	reviewed	Transporter
P49448	BXGT010709	Glutamate dehydrogenase 2, mitochondrial	2747	reviewed	Enzyme
P49711	BXGT010728	Transcriptional repressor CTCF	10664	reviewed	Transcription factor
P49810	BXGT010747	Presenilin-2	5664	reviewed	Enzyme
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P51617	BXGT010868	Interleukin-1 receptor-associated kinase 1	3654	reviewed	Kinase
P51649	BXGT010872	Succinate-semialdehyde dehydrogenase, mitochondrial	7915	reviewed	Enzyme
P54132	BXGT011032	Bloom syndrome protein	641	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61106	BXGT011360	Ras-related protein Rab-14	51552	reviewed
P62805	BXGT011457	Histone H4	8370	reviewed
P63279	BXGT011514	SUMO-conjugating enzyme UBC9	7329	reviewed
P68363	BXGT011594	Tubulin alpha-1B chain	10376	reviewed	Cellular structure
P78563	BXGT011850	Double-stranded RNA-specific editase 1	104	reviewed	Enzyme
Q02363	BXGT012650	DNA-binding protein inhibitor ID-2	3398	reviewed	Transcription factor
Q05193	BXGT012810	Dynamin-1	1759	reviewed	Enzyme modulator
Q05586	BXGT012826	Glutamate receptor ionotropic, NMDA 1	2902	reviewed	Ion channel
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q09472	BXGT013038	Histone acetyltransferase p300	2033	reviewed
Q12756	BXGT013261	Kinesin-like protein KIF1A	547	reviewed	Cellular structure
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q14204	BXGT013456	Cytoplasmic dynein 1 heavy chain 1	1778	reviewed	Enzyme
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q14721	BXGT013502	Potassium voltage-gated channel subfamily B member 1	3745	reviewed	Ion channel
Q14831	BXGT013506	Metabotropic glutamate receptor 7	2917	reviewed	G-protein coupled receptor
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15118	BXGT013540	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	5163	reviewed	Kinase
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16775	BXGT013669	Hydroxyacylglutathione hydrolase, mitochondrial	3029	reviewed
Q2TU34	BXGT014223	Fructose-1,6-bisphosphatase 1	2203	unreviewed
Q86TM3	BXGT017607	Probable ATP-dependent RNA helicase DDX53	168400	reviewed
Q8IXJ6	BXGT018362	NAD-dependent protein deacetylase sirtuin-2	22933	reviewed	Epigenetic regulator
Q92769	BXGT019370	Histone deacetylase 2	3066	reviewed	Epigenetic regulator
Q92793	BXGT019374	CREB-binding protein	1387	reviewed
Q96CW9	BXGT019634	Netrin-G2	84628	reviewed	Enzyme modulator
Q99623	BXGT019941	Prohibitin-2	11331	reviewed
Q99653	BXGT019945	Calcineurin B homologous protein 1	11261	reviewed
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9H2X9	BXGT020459	Solute carrier family 12 member 5	57468	reviewed	Transporter
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UBN7	BXGT021658	Histone deacetylase 6	10013	reviewed	Epigenetic regulator
Q9UBS5	BXGT021662	Gamma-aminobutyric acid type B receptor subunit 1	2550	reviewed	G-protein coupled receptor
Q9Y2I2	BXGT022236	Netrin-G1	22854	reviewed	Enzyme modulator
Q9Y2T6	BXGT022247	G-protein coupled receptor 55	9290	reviewed	G-protein coupled receptor
Q9Y618	BXGT022315	Nuclear receptor corepressor 2	9612	reviewed	Transcription factor
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
Q05086	BXGT025648	Ubiquitin-protein ligase E3A	7337	reviewed
Q8TAB3	BXGT025819	Protocadherin-19	57526	reviewed
Q96AE4	BXGT025980	Far upstream element-binding protein 1	8880	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}