Showing entry for Mitogen-activated protein kinase 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009511
Protein NameMitogen-activated protein kinase 4
Uniport IdP31152
GeneMAPK4
Gene Id5596
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04657 IL-17 signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0010468 regulation of gene expression
molecular function GO:0005524 ATP binding
molecular function GO:0004707 MAP kinase activity
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5687128 MAPK6/MAPK4 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0027651 BXGD002009 Neoplasms Neoplasms
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200633 BXGD004040 Neutrophil count (procedure)
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0857490 BXGD011150 Granulocyte count
C0871470 BXGD011316 Systolic Pressure
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein