adisease

Showing entry for Leishmaniasis

General Disease Information
BXGD Id	BXGD001628
Disease Name	Leishmaniasis
Disease CUI Id	C0023281
MeSH Codes	C01 C17
Disease Class Name	Infections; Skin and Connective Tissue Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:7 DOID:0050117
Disease Ontology Class Name	disease of anatomical entity; disease by infectious agent
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00341	BXGT003913	Excitatory amino acid transporter 5	6512	reviewed	Transporter
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O43813	BXGT004628	Glutathione S-transferase LANCL1	10314	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O94788	BXGT005333	Retinal dehydrogenase 2	8854	reviewed	Enzyme
P00156	BXGT005469	Cytochrome b	4519	reviewed
P00352	BXGT005510	Retinal dehydrogenase 1	216	reviewed	Enzyme
P00374	BXGT005520	Dihydrofolate reductase	1719	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00813	BXGT005667	Adenosine deaminase	100	reviewed	Enzyme
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01574	BXGT005768	Interferon beta	3456	reviewed
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P04083	BXGT006147	Annexin A1	301	reviewed
P04406	BXGT006207	Glyceraldehyde-3-phosphate dehydrogenase	2597	reviewed	Enzyme
P05089	BXGT006310	Arginase-1	383	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06126	BXGT006412	T-cell surface glycoprotein CD1a	909	reviewed
P07384	BXGT006619	Calpain-1 catalytic subunit	823	reviewed	Enzyme
P07711	BXGT006661	Cathepsin L1	1514	reviewed	Enzyme
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07858	BXGT006689	Cathepsin B	1508	reviewed	Enzyme
P08865	BXGT006832	40S ribosomal protein SA	3921	reviewed	Nucleic acid binding
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10747	BXGT007609	T-cell-specific surface glycoprotein CD28	940	reviewed
P10809	BXGT007617	60 kDa heat shock protein, mitochondrial	3329	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11940	BXGT007762	Polyadenylate-binding protein 1	26986	reviewed
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P13051	BXGT007877	Uracil-DNA glycosylase	7374	reviewed
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13612	BXGT007928	Integrin alpha-4	3676	reviewed
P13639	BXGT007934	Elongation factor 2	1938	reviewed	Enzyme
P15086	BXGT008078	Carboxypeptidase B	1360	reviewed	Enzyme
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P16070	BXGT008186	CD44 antigen	960	reviewed
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P17706	BXGT008330	Tyrosine-protein phosphatase non-receptor type 2	5771	reviewed
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	5770	reviewed
P19525	BXGT008492	Interferon-induced, double-stranded RNA-activated protein kinase	5610	reviewed	Kinase
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P22830	BXGT008809	Ferrochelatase, mitochondrial	2235	reviewed	Enzyme
P22897	BXGT008816	Macrophage mannose receptor 1	4360	reviewed
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P25325	BXGT009038	3-mercaptopyruvate sulfurtransferase	4357	reviewed	Enzyme
P25942	BXGT009079	Tumor necrosis factor receptor superfamily member 5	958	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29350	BXGT009335	Tyrosine-protein phosphatase non-receptor type 6	5777	reviewed
P29372	BXGT009336	DNA-3-methyladenine glycosylase	4350	reviewed	Enzyme
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30044	BXGT009395	Peroxiredoxin-5, mitochondrial	25824	reviewed
P30046	BXGT009396	D-dopachrome decarboxylase	1652	reviewed	Enzyme
P31152	BXGT009511	Mitogen-activated protein kinase 4	5596	reviewed	Kinase
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35557	BXGT009846	Glucokinase	2645	reviewed	Kinase
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42224	BXGT010286	Signal transducer and activator of transcription 1-alpha/beta	6772	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P51665	BXGT010874	26S proteasome non-ATPase regulatory subunit 7	5713	reviewed	Enzyme
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P62753	BXGT011454	40S ribosomal protein S6	6194	reviewed	Nucleic acid binding
P80075	BXGT011876	C-C motif chemokine 8	6355	reviewed	Signaling
Q02779	BXGT012670	Mitogen-activated protein kinase kinase kinase 10	4294	reviewed	Kinase
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q07812	BXGT012940	Apoptosis regulator BAX	581	reviewed	Signaling
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13535	BXGT013370	Serine/threonine-protein kinase ATR	545	reviewed	Kinase
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14232	BXGT013457	Translation initiation factor eIF-2B subunit alpha	1967	reviewed
Q15078	BXGT013534	Cyclin-dependent kinase 5 activator 1	8851	reviewed	Enzyme modulator
Q15485	BXGT013574	Ficolin-2	2220	reviewed	Signaling
Q15758	BXGT013594	Neutral amino acid transporter B(0)	6510	reviewed	Transporter
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16850	BXGT013681	Lanosterol 14-alpha demethylase	1595	reviewed	Enzyme
Q8TCT9	BXGT018801	Minor histocompatibility antigen H13	81502	reviewed	Enzyme
Q96GD0	BXGT019665	Pyridoxal phosphate phosphatase	57026	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9C098	BXGT020208	Serine/threonine-protein kinase DCLK3	85443	reviewed	Kinase
Q9H0R8	BXGT020441	Gamma-aminobutyric acid receptor-associated protein-like 1	23710	reviewed	Cellular structure
Q9H3H5	BXGT020461	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	1798	reviewed	Enzyme
Q9HD26	BXGT020540	Golgi-associated PDZ and coiled-coil motif-containing protein	57120	reviewed
Q9NR19	BXGT021175	Acetyl-coenzyme A synthetase, cytoplasmic	55902	reviewed	Enzyme
Q9NYA1	BXGT021254	Sphingosine kinase 1	8877	reviewed	Kinase
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9Y275	BXGT022223	Tumor necrosis factor ligand superfamily member 13B	10673	reviewed
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
Q9Y5S8	BXGT022302	NADPH oxidase 1	27035	reviewed
P35232	BXGT022663	Prohibitin	5245	reviewed
Q01543	BXGT023137	Friend leukemia integration 1 transcription factor	2313	reviewed	Transcription factor
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q9BYE2	BXGT024631	Transmembrane protease serine 13	84000	reviewed	Enzyme
P25090	BXGT025102	N-formyl peptide receptor 2	2358	reviewed	G-protein coupled receptor

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}