Showing entry for Metabotropic glutamate receptor 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009542
Protein NameMetabotropic glutamate receptor 5
Uniport IdP31424
GeneGrm5
Gene Id24418
Domain7tm_3; ANF_receptor; GluR_Homer-bdg; NCD3G
Pfam PF00003   PF01094   PF10606   PF07562  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000185 activation of MAPKKK activity
Biological Process GO:0035584 calcium-mediated signaling using intracellular calcium source
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0050890 cognition
Biological Process GO:0002029 desensitization of G protein-coupled receptor signaling pathway
Biological Process GO:0007216 G protein-coupled glutamate receptor signaling pathway
Biological Process GO:0007612 learning
Biological Process GO:0007611 learning or memory
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0090647 modulation of age-related behavioral decline
Biological Process GO:0040013 negative regulation of locomotion
Biological Process GO:0048015 phosphatidylinositol-mediated signaling
Biological Process GO:0007206 phospholipase C-activating G protein-coupled glutamate receptor signaling pathway
Biological Process GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Biological Process GO:0048170 positive regulation of long-term neuronal synaptic plasticity
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission
Biological Process GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:1902938 regulation of intracellular calcium activated chloride channel activity
Biological Process GO:0048169 regulation of long-term neuronal synaptic plasticity
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0006448 regulation of translational elongation
Biological Process GO:0050808 synapse organization
Biological Process GO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
molecular function GO:0031687 A2A adenosine receptor binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0008066 glutamate receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
molecular function GO:0042802 identical protein binding
molecular function GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
molecular function GO:0030165 PDZ domain binding
molecular function GO:0001639 PLC activating G protein-coupled glutamate receptor activity
molecular function GO:1990782 protein tyrosine kinase binding
cellular component GO:0097449 astrocyte projection
cellular component GO:0005737 cytoplasm
cellular component GO:0043198 dendritic shaft
cellular component GO:0043197 dendritic spine
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0016020 membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0098685 Schaffer collateral - CA1 synapse
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000651 Harmalan 184.24
BXGC0001545 Harmine 212.25
BXGC0006162 L-Glutamic acid 147.13
BXGC0006163 Glutamic acid 147.13
BXGC0023948 (S)-2-Aminoadipic Acid 161.07
BXGC0036441 Quisqualate 189.04
BXGC0036476 D-Glutamate 147.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein