Showing entry for Harmine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001545
Compound NameHarmine
Structure
FormulaC13H12N2O
InchiKeyBXNJHAXVSOCGBA-UHFFFAOYSA-N
SMILESCOC1=CC=C2C(NC3=C2C=CN=C3C)=C1
InchiInChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
IUPAC7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
Molecular Weight212.25
Pubchem Id5280953
Chembl IdCHEMBL269538
Targets of Information Source
DrugBank DB07919
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA experimental -
PDB HRM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA - - - - -
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed DYRK1A Kinase - - - -
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed DYRK3 Kinase - 800 - -
Binding DB 100152
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT010752 Kallikrein-7 reviewed Enzyme KLK7 - - - 24845
reviewed BXGT022235 Nischarin reviewed Enzyme modulator NISCH 22 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 1130 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 >10000 - - -
reviewed BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 >10000 - - -
reviewed BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 >10000 - - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 50000 - - -
reviewed BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA - >250000 - -
reviewed BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 - 21000 - -
reviewed BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 - 35000 - -
reviewed BXGT006445 Cyclin-dependent kinase 1 reviewed Kinase CDK1 - 18000 - -
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - >250000 - -
reviewed BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN - >250000 - -
reviewed BXGT006702 Tyrosine-protein kinase Lyn reviewed Kinase LYN - >250000 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 60 - -
reviewed BXGT010594 5-hydroxytryptamine receptor 5A reviewed G-protein coupled receptor HTR5A >10000 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 7790 - - -
reviewed BXGT009540 Metabotropic glutamate receptor 3 reviewed Grm3 >10000 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 5500 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B >10000 - - -
reviewed BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 >10000 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A >10000 - - -
reviewed BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B >10000 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 810 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 1480 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A >10000 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 2540 - - -
reviewed BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D >10000 - - -
reviewed BXGT009214 Sodium-dependent dopamine transporter reviewed SLC6A3 >10000 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 9340 - - -
reviewed BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 3260 - - -
reviewed BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 >10000 - - -
reviewed BXGT021176 Dual specificity tyrosine-phosphorylation-regulated kinase 4 reviewed Kinase DYRK4 - 74000 - -
reviewed BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 - 2000 - -
reviewed BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B - 166 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 33 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 80 - -
reviewed BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 - 3000 - -
reviewed BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B - 180 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 130 - -
reviewed BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 - 220 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 400 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 29 - -
reviewed BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B - >10000 - -
reviewed BXGT010725 Casein kinase I isoform epsilon reviewed CSNK1E - 1500 - -
reviewed BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 - 72 - -
reviewed BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 - 26 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 30 - -
reviewed BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 - >10000 - -
reviewed BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA 5 - - -
reviewed BXGT022235 Nischarin reviewed Enzyme modulator NISCH 13800 - - -
reviewed BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA 17 - - -
reviewed BXGT009172 Amine oxidase [flavin-containing] B reviewed MAOB 120800 - - -
reviewed BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D - 1500 - -
reviewed BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 - 900 - -
reviewed BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 - 800 - -
reviewed BXGT017617 Serine/threonine-protein kinase pim-3 reviewed PIM3 - 4300 - -
reviewed BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 - 690 - -
reviewed BXGT018826 Serine/threonine-protein kinase haspin reviewed Kinase HASPIN - 590 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 22890 - -
reviewed BXGT010749 Glycogen synthase kinase-3 alpha reviewed Kinase GSK3A - >10000 - -
reviewed BXGT011494 Mitogen-activated protein kinase 1 reviewed Mapk1 - >30000 - -
reviewed BXGT021176 Dual specificity tyrosine-phosphorylation-regulated kinase 4 reviewed Kinase DYRK4 - 9500 - -
reviewed BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 - 210 - -
reviewed BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 - 120 - -
reviewed BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B - 28 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A - 85 - -
reviewed BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Dyrk1a - 34 - -
reviewed BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Dyrk1a - 56 - -
reviewed BXGT004532 Dual specificity protein kinase CLK4 reviewed Clk4 - 50 - -
reviewed BXGT004531 Dual specificity protein kinase CLK3 reviewed Clk3 - >10000 - -
reviewed BXGT004530 Dual specificity protein kinase CLK2 reviewed Clk2 - 280 - -
reviewed BXGT004883 Cyclin-T1 reviewed Enzyme modulator CCNT1 - 720 - -
reviewed BXGT010907 Cyclin-H reviewed Enzyme modulator CCNH - >10000 - -
reviewed BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 - 8000 - -
reviewed BXGT008779 Dual specificity protein kinase CLK1 reviewed Clk1 - 72 - -
reviewed BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Dyrk1a - 29 - -
reviewed BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A 33 - - -
reviewed BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B 166 - - -
CHEMBL CHEMBL269538
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 85 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a IC50 '=' 34 nM
P78396 BXGT011842 Cyclin-A1 reviewed Enzyme modulator CCNA1 IC50 '>' 30000 nM
P20248 BXGT008554 Cyclin-A2 reviewed Enzyme modulator CCNA2 IC50 '>' 30000 nM
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 IC50 '>' 30000 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 3548 nM
P49137 BXGT010680 MAP kinase-activated protein kinase 2 reviewed Kinase MAPKAPK2 Activity '=' 110 %
Q8TDX7 BXGT018817 Serine/threonine-protein kinase Nek7 reviewed Kinase NEK7 Activity '=' 108 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 10000 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 89125 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 5011 nM
P35368 BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B Ki '>' 10000 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki '>' 10000 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '>' 10000 nM
Q9Y2I1 BXGT022235 Nischarin reviewed Enzyme modulator NISCH Ki '=' 13800 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 50118 nM
P47898 BXGT010594 5-hydroxytryptamine receptor 5A reviewed G-protein coupled receptor HTR5A Ki '>' 10000 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki '=' 1130 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 7790 nM
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A Ki '>' 10000 nM
Q9Y2I1 BXGT022235 Nischarin reviewed Enzyme modulator NISCH Ki '=' 22 nM
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 IC50 '=' 3000 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 80 nM
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 IC50 '=' 26 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki '=' 50000 nM
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 IC50 '=' 8000 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 IC50 '=' 8000 nM
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 reviewed Kinase SGK1 Activity '=' 83 %
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 reviewed Kinase CHEK2 Activity '=' 100 %
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki '=' 5 nM
Q9HBH9 BXGT020521 MAP kinase-interacting serine/threonine-protein kinase 2 reviewed Kinase MKNK2 Activity '=' 80 %
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Activity '=' 95 %
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 reviewed Kinase PDPK1 Activity '=' 87 %
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Activity '=' 86 %
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle reviewed Kinase MYLK Activity '=' 87 %
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 IC50 '>' 10000 nM
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 IC50 '=' 900 nM
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B Inhibition - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 7943 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 10000 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a IC50 '=' 29 nM
Q9NR20 BXGT021176 Dual specificity tyrosine-phosphorylation-regulated kinase 4 reviewed Kinase DYRK4 IC50 '=' 74000 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Activity '=' 97 %
Q96SB4 BXGT019740 SRSF protein kinase 1 reviewed Kinase SRPK1 Activity '=' 86 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Activity '=' 105 %
Q8IW41 BXGT018352 MAP kinase-activated protein kinase 5 reviewed Kinase MAPKAPK5 Activity '=' 90 %
P41240 BXGT010242 Tyrosine-protein kinase CSK reviewed Kinase CSK Activity '=' 86 %
Q9HAZ1 BXGT020511 Dual specificity protein kinase CLK4 reviewed - CLK4 Potency - 67 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 400 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9441 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '>' 10000 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '>' 10000 nM
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Ki '>' 10000 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki '>' 10000 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '>' 10000 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki '>' 10000 nM
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki '>' 10000 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki '>' 10000 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki '>' 10000 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki '>' 10000 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 35481 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 11220 nM
P78396 BXGT011842 Cyclin-A1 reviewed Enzyme modulator CCNA1 IC50 '=' 35000 nM
P20248 BXGT008554 Cyclin-A2 reviewed Enzyme modulator CCNA2 IC50 '=' 35000 nM
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 IC50 '=' 35000 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 25118 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki '=' 16 nM
Q8WXA8 BXGT019008 5-hydroxytryptamine receptor 3C reviewed Ion channel HTR3C Ki '>' 10000 nM
Q70Z44 BXGT016686 5-hydroxytryptamine receptor 3D reviewed Ion channel HTR3D Ki '>' 10000 nM
O95264 BXGT005367 5-hydroxytryptamine receptor 3B reviewed Ion channel HTR3B Ki '>' 10000 nM
A5X5Y0 BXGT001376 5-hydroxytryptamine receptor 3E reviewed Ion channel HTR3E Ki '>' 10000 nM
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A Ki '>' 10000 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 105 %
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 8912 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 12589 nM
Q16644 BXGT013647 MAP kinase-activated protein kinase 3 reviewed Kinase MAPKAPK3 Activity '=' 98 %
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 AC50 '=' 23 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 28183 nM
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ Activity '=' 83 %
Q9NQU5 BXGT021169 Serine/threonine-protein kinase PAK 6 reviewed - PAK6 Activity '=' 83 %
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Activity - - -
Q9H2X6 BXGT020458 Homeodomain-interacting protein kinase 2 reviewed Kinase HIPK2 Activity '=' 108 %
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 101 %
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki '=' 2540 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Activity '=' 4 %
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Ki '>' 10000 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki '=' 1480 nM
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki '=' 3260 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 28183 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 Activity '=' 15 %
P78396 BXGT011842 Cyclin-A1 reviewed Enzyme modulator CCNA1 Activity '=' 86 %
P20248 BXGT008554 Cyclin-A2 reviewed Enzyme modulator CCNA2 Activity '=' 86 %
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Activity '=' 86 %
Q9H422 BXGT020469 Homeodomain-interacting protein kinase 3 reviewed Kinase HIPK3 Activity '=' 87 %
P28222 BXGT009238 5-hydroxytryptamine receptor 1B reviewed G-protein coupled receptor HTR1B Ki '>' 10000 nM
P34969 BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 Ki '=' 5500 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki '=' 810 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Ki '=' 33 nM
P06240 BXGT006428 Proto-oncogene tyrosine-protein kinase LCK reviewed - Lck Activity '=' 81 %
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB Activity '=' 73 %
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Activity '=' 68 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Activity '=' 68 %
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Activity '=' 68 %
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 82 %
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 31622 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 12589 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 14125 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 7943 nM
O00418 BXGT003918 Eukaryotic elongation factor 2 kinase reviewed Kinase EEF2K Activity '=' 104 %
P28593 BXGT009278 Trypanothione reductase reviewed - TPR Inhibition '=' 11 %
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Ki '=' 120800 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 Inhibition '=' 68 %
Q8TF76 BXGT018826 Serine/threonine-protein kinase haspin reviewed Kinase HASPIN IC50 '=' 590 nM
P29030 BXGT009307 Endochitinase reviewed - Inhibition - - -
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Activity '=' 80 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Activity '=' 104 %
P49840 BXGT010749 Glycogen synthase kinase-3 alpha reviewed Kinase GSK3A IC50 '>' 10000 nM
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D Activity '=' 60 %
P53779 BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 Activity '=' 91 %
Q8IWQ3 BXGT018355 Serine/threonine-protein kinase BRSK2 reviewed Kinase BRSK2 Activity '=' 83 %
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha reviewed Kinase PRKACA Activity '=' 80 %
Q16513 BXGT013632 Serine/threonine-protein kinase N2 reviewed Kinase PKN2 Activity '=' 86 %
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase reviewed Kinase MELK Activity '=' 8 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Activity '=' 87 %
Q96GD4 BXGT019667 Aurora kinase B reviewed Kinase AURKB Activity '=' 81 %
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Activity '=' 101 %
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 IC50 '=' 410 nM
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 IC50 '=' 2000 nM
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 Activity '=' 80 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 15848 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 39810 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 29 nM
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B IC50 '>' 10000 nM
P49840 BXGT010749 Glycogen synthase kinase-3 alpha reviewed Kinase GSK3A IC50 '>' 10000 nM
Q9UQB9 BXGT021810 Aurora kinase C reviewed Kinase AURKC Activity '=' 83 %
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D IC50 '=' 1500 nM
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 IC50 '=' 800 nM
Q86V86 BXGT017617 Serine/threonine-protein kinase pim-3 reviewed - PIM3 IC50 '=' 4300 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 60 nM
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 AC50 '=' 11 nM
P50750 BXGT010818 Cyclin-dependent kinase 9 reviewed Kinase CDK9 IC50 '=' 720 nM
O60563 BXGT004883 Cyclin-T1 reviewed Enzyme modulator CCNT1 IC50 '=' 720 nM
P63086 BXGT011494 Mitogen-activated protein kinase 1 reviewed - Mapk1 IC50 '>' 30000 nM
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 IC50 '>' 10000 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 IC50 '>' 10000 nM
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B Ki '=' 166 nM
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 Activity '=' 3 %
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Activity '=' 88 %
P23385 BXGT008861 Metabotropic glutamate receptor 1 reviewed - Grm1 Ki '>' 10000 nM
P35400 BXGT009826 Metabotropic glutamate receptor 7 reviewed - Grm7 Ki '>' 10000 nM
P35349 BXGT009815 Metabotropic glutamate receptor 6 reviewed - Grm6 Ki '>' 10000 nM
P31422 BXGT009540 Metabotropic glutamate receptor 3 reviewed - Grm3 Ki '>' 10000 nM
P31421 BXGT009539 Metabotropic glutamate receptor 2 reviewed - Grm2 Ki '>' 10000 nM
P31423 BXGT009541 Metabotropic glutamate receptor 4 reviewed - Grm4 Ki '>' 10000 nM
P70579 BXGT011675 Metabotropic glutamate receptor 8 reviewed - Grm8 Ki '>' 10000 nM
P31424 BXGT009542 Metabotropic glutamate receptor 5 reviewed - Grm5 Ki '>' 10000 nM
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase reviewed Kinase AKT2 Activity '=' 90 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 10000 nM
O35492 BXGT004531 Dual specificity protein kinase CLK3 reviewed - Clk3 IC50 '>' 10000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 9340 nM
O75582 BXGT005137 Ribosomal protein S6 kinase alpha-5 reviewed Kinase RPS6KA5 Activity '=' 83 %
Q8TD08 BXGT018803 Mitogen-activated protein kinase 15 reviewed Kinase MAPK15 Activity '=' 80 %
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 6309 nM
Q9ES14 BXGT020314 Gamma-aminobutyric acid receptor subunit epsilon reviewed - Gabre Ki '>' 10000 nM
Q91ZM7 BXGT019327 GABA theta subunit unreviewed - Gabrq Ki '>' 10000 nM
P63138 BXGT011502 Gamma-aminobutyric acid receptor subunit beta-2 reviewed - Gabrb2 Ki '>' 10000 nM
P63079 BXGT011491 Gamma-aminobutyric acid receptor subunit beta-3 reviewed - Gabrb3 Ki '>' 10000 nM
P62813 BXGT011460 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed - Gabra1 Ki '>' 10000 nM
P30191 BXGT009410 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed - Gabra6 Ki '>' 10000 nM
P28473 BXGT009261 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed - Gabrg3 Ki '>' 10000 nM
P28471 BXGT009259 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed - Gabra4 Ki '>' 10000 nM
P23576 BXGT008885 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed - Gabra2 Ki '>' 10000 nM
P23574 BXGT008884 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed - Gabrg1 Ki '>' 10000 nM
P20236 BXGT008551 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed - Gabra3 Ki '>' 10000 nM
P19969 BXGT008536 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed - Gabra5 Ki '>' 10000 nM
P18508 BXGT008412 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed - Gabrg2 Ki '>' 10000 nM
P18506 BXGT008410 Gamma-aminobutyric acid receptor subunit delta reviewed - Gabrd Ki '>' 10000 nM
P15431 BXGT008122 Gamma-aminobutyric acid receptor subunit beta-1 reviewed - Gabrb1 Ki '>' 10000 nM
O09028 BXGT004049 Gamma-aminobutyric acid receptor subunit pi reviewed - Gabrp Ki '>' 10000 nM
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Inhibition '=' 62 %
Q04759 BXGT012781 Protein kinase C theta type reviewed Kinase PRKCQ IC50 '>' 250000 nM
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 IC50 '>' 250000 nM
P24723 BXGT008989 Protein kinase C eta type reviewed Kinase PRKCH IC50 '>' 250000 nM
Q02156 BXGT012639 Protein kinase C epsilon type reviewed Kinase PRKCE IC50 '>' 250000 nM
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ IC50 '>' 250000 nM
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB IC50 '>' 250000 nM
Q05655 BXGT012832 Protein kinase C delta type reviewed Kinase PRKCD IC50 '>' 250000 nM
P05129 BXGT006322 Protein kinase C gamma type reviewed Kinase PRKCG IC50 '>' 250000 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 '>' 250000 nM
P41743 BXGT010270 Protein kinase C iota type reviewed Kinase PRKCI IC50 '>' 250000 nM
O94806 BXGT005335 Serine/threonine-protein kinase D3 reviewed Kinase PRKD3 IC50 '>' 250000 nM
Q13188 BXGT013324 Serine/threonine-protein kinase 3 reviewed Kinase STK3 Activity '=' 85 %
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Activity '=' 89 %
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 15848 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '>' 250000 nM
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 reviewed Kinase PIM2 Activity '=' 88 %
P08238 BXGT006753 Heat shock protein HSP 90-beta reviewed Chaperone HSP90AB1 Activity - - -
P07900 BXGT006696 Heat shock protein HSP 90-alpha reviewed Chaperone HSP90AA1 Activity - - -
Q96RR4 BXGT019734 Calcium/calmodulin-dependent protein kinase kinase 2 reviewed Kinase CAMKK2 Activity '=' 81 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 5623 nM
P50613 BXGT010815 Cyclin-dependent kinase 7 reviewed Kinase CDK7 IC50 '>' 10000 nM
P51946 BXGT010907 Cyclin-H reviewed Enzyme modulator CCNH IC50 '>' 10000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11582 nM
P07948 BXGT006702 Tyrosine-protein kinase Lyn reviewed Kinase LYN IC50 '>' 250000 nM
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 '>' 250000 nM
O95067 BXGT005347 G2/mitotic-specific cyclin-B2 reviewed Enzyme modulator CCNB2 IC50 '=' 18000 nM
Q8WWL7 BXGT019000 G2/mitotic-specific cyclin-B3 reviewed Enzyme modulator CCNB3 IC50 '=' 18000 nM
P14635 BXGT008031 G2/mitotic-specific cyclin-B1 reviewed Enzyme modulator CCNB1 IC50 '=' 18000 nM
P06493 BXGT006445 Cyclin-dependent kinase 1 reviewed Kinase CDK1 IC50 '=' 18000 nM
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 IC50 '=' 21000 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 IC50 '=' 21000 nM
P51955 BXGT010908 Serine/threonine-protein kinase Nek2 reviewed Kinase NEK2 Activity '=' 94 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 22890 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 23 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 8912 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a IC50 '=' 56 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 7943 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 12589 nM
Q9P286 BXGT021299 Serine/threonine-protein kinase PAK 5 reviewed Kinase PAK5 Activity '=' 92 %
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Activity '=' 103 %
P00523 BXGT005572 Proto-oncogene tyrosine-protein kinase Src reviewed - SRC Activity '=' 88 %
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 19952 nM
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 99 %
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 3162 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 398 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 12995 nM
P49761 BXGT010736 Dual specificity protein kinase CLK3 reviewed Kinase CLK3 Activity - - -
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a Inhibition - - -
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 31622 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 15848 nM
Q9NR20 BXGT021176 Dual specificity tyrosine-phosphorylation-regulated kinase 4 reviewed Kinase DYRK4 IC50 '=' 80000 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 33 nM
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 reviewed Kinase MKNK1 Activity '=' 82 %
P28221 BXGT009237 5-hydroxytryptamine receptor 1D reviewed G-protein coupled receptor HTR1D Ki '>' 10000 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki '>' 10000 nM
P27922 BXGT009214 Sodium-dependent dopamine transporter reviewed - SLC6A3 Ki '>' 10000 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
Q14012 BXGT013437 Calcium/calmodulin-dependent protein kinase type 1 reviewed Kinase CAMK1 Activity '=' 94 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Activity '=' 73 %
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B IC50 '=' 28 nM
I6LNT8 BXGT026102 [Tau protein] kinase unreviewed - GSK3A IC50 '>' 10000 nM
B2LUN4 BXGT026103 Glycogen synthase kinase-3 beta unreviewed - GSK3-beta IC50 '>' 10000 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Activity '=' 95 %
P17405 BXGT008304 Sphingomyelin phosphodiesterase reviewed Enzyme SMPD1 Activity '=' 92 %
O96013 BXGT005414 Serine/threonine-protein kinase PAK 4 reviewed Kinase PAK4 Activity '=' 96 %
O43293 BXGT004584 Death-associated protein kinase 3 reviewed Kinase DAPK3 Activity '=' 69 %
Q9H2X6 BXGT020458 Homeodomain-interacting protein kinase 2 reviewed Kinase HIPK2 Activity '=' 8 %
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 reviewed Kinase RPS6KB1 Activity '=' 93 %
Q9HC98 BXGT020528 Serine/threonine-protein kinase Nek6 reviewed Kinase NEK6 Activity '=' 87 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B IC50 - - -
Q25615 BXGT013900 Chitinase unreviewed - Ki '=' 3780 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki '=' 17 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Inhibition '>' 60 %
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 130 nM
P05771 BXGT006384 Protein kinase C beta type reviewed Kinase PRKCB IC50 - - -
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B IC50 '=' 166 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 15848 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 30 nM
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 Activity '=' 6 %
P45984 BXGT010495 Mitogen-activated protein kinase 9 reviewed Kinase MAPK9 Activity '=' 91 %
Q8N5S9 BXGT018520 Calcium/calmodulin-dependent protein kinase kinase 1 reviewed Kinase CAMKK1 Activity '=' 95 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B IC50 '>' 10000 nM
Q9NR20 BXGT021176 Dual specificity tyrosine-phosphorylation-regulated kinase 4 reviewed Kinase DYRK4 IC50 '=' 9500 nM
P50613 BXGT010815 Cyclin-dependent kinase 7 reviewed Kinase CDK7 Activity '=' 21 %
P78368 BXGT011840 Casein kinase I isoform gamma-2 reviewed Kinase CSNK1G2 Activity '=' 19 %
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 IC50 '=' 210 nM
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 IC50 '=' 120 nM
O35493 BXGT004532 Dual specificity protein kinase CLK4 reviewed - Clk4 IC50 '=' 50 nM
O35491 BXGT004530 Dual specificity protein kinase CLK2 reviewed - Clk2 IC50 '=' 280 nM
P22518 BXGT008779 Dual specificity protein kinase CLK1 reviewed - Clk1 IC50 '=' 72 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 19952 nM
P49760 BXGT010735 Dual specificity protein kinase CLK2 reviewed Kinase CLK2 Activity - - -
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 Activity - - -
O75676 BXGT005144 Ribosomal protein S6 kinase alpha-4 reviewed Kinase RPS6KA4 Activity '=' 40 %
Q9HAZ1 BXGT020511 Dual specificity protein kinase CLK4 reviewed - CLK4 Activity - - -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 11220 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 31622 nM
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D Activity '=' 13 %
P49674 BXGT010725 Casein kinase I isoform epsilon reviewed - CSNK1E Activity '=' 1 %
Q9UBF8 BXGT021653 Phosphatidylinositol 4-kinase beta reviewed Kinase PI4KB Activity '=' 12 %
P27448 BXGT009183 MAP/microtubule affinity-regulating kinase 3 reviewed Kinase MARK3 Activity '=' 83 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Activity '=' 100 %
I6LNT8 BXGT026102 [Tau protein] kinase unreviewed - GSK3A IC50 '=' 19000 nM
B2LUN4 BXGT026103 Glycogen synthase kinase-3 beta unreviewed - GSK3-beta IC50 '=' 19000 nM
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B Activity - - -
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B Activity '=' 6 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 2059 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 41 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11885 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 2310 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 1636 nM
Q86V86 BXGT017617 Serine/threonine-protein kinase pim-3 reviewed - PIM3 Activity '=' 64 %
O75116 BXGT005100 Rho-associated protein kinase 2 reviewed Kinase ROCK2 Activity '=' 80 %
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B IC50 '=' 180 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 8 nM
Q86Z02 BXGT017638 Homeodomain-interacting protein kinase 1 reviewed Kinase HIPK1 Activity '=' 21 %
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 IC50 '=' 690 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 23109 nM
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 IC50 '=' 72 nM
Q25615 BXGT013900 Chitinase unreviewed - IC50 '=' 7060 nM
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Inhibition - - -
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Inhibition - - -
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Inhibition - - -
P37173 BXGT009970 TGF-beta receptor type-2 reviewed Kinase TGFBR2 Activity '=' 78 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 4109 nM
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 Activity - - -
P53355 BXGT010985 Death-associated protein kinase 1 reviewed Kinase DAPK1 Activity '=' 78 %
O95644 BXGT005389 Nuclear factor of activated T-cells, cytoplasmic 1 reviewed Transcription factor NFATC1 EC50 - - -
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 56234 nM
P49674 BXGT010725 Casein kinase I isoform epsilon reviewed - CSNK1E IC50 '=' 1500 nM
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D IC50 '=' 1500 nM
I6LNT8 BXGT026102 [Tau protein] kinase unreviewed - GSK3A IC50 '<' 10000 nM
B2LUN4 BXGT026103 Glycogen synthase kinase-3 beta unreviewed - GSK3-beta IC50 '<' 10000 nM
Q9Y463 BXGT022269 Dual specificity tyrosine-phosphorylation-regulated kinase 1B reviewed Kinase DYRK1B IC50 '=' 160 nM
P51617 BXGT010868 Interleukin-1 receptor-associated kinase 1 reviewed Kinase IRAK1 Activity '=' 17 %
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 IC50 '>' 10000 nM
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 IC50 '>' 10000 nM
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 IC50 '>' 10000 nM
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 IC50 '>' 10000 nM
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 IC50 '>' 10000 nM
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 IC50 '>' 10000 nM
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 IC50 '>' 10000 nM
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 IC50 '>' 10000 nM
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 IC50 '>' 10000 nM
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 IC50 '>' 10000 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 '>' 10000 nM
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 IC50 - - -
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 - - -
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 74 %
P20248 BXGT008554 Cyclin-A2 reviewed Enzyme modulator CCNA2 IC50 '<' 10000 nM
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 IC50 '<' 10000 nM
P49336 BXGT010697 Cyclin-dependent kinase 8 reviewed Kinase CDK8 Activity '=' 55 %
P49760 BXGT010735 Dual specificity protein kinase CLK2 reviewed Kinase CLK2 Activity '=' 2 %
Q9HAZ1 BXGT020511 Dual specificity protein kinase CLK4 reviewed - CLK4 Activity '=' 13 %
P48729 BXGT010655 Casein kinase I isoform alpha reviewed Kinase CSNK1A1 Activity '=' 15 %
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Activity '=' 23 %
O94768 BXGT005331 Serine/threonine-protein kinase 17B reviewed Kinase STK17B Activity '=' 73 %
Q9Y616 BXGT022313 Interleukin-1 receptor-associated kinase 3 reviewed Kinase IRAK3 Activity '=' 15 %
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 reviewed Kinase PIM2 Activity '=' 39 %
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 IC50 '=' 220 nM
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 Inhibition - - -
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 7943 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Activity '=' 0 %
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 700 nM
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Activity '=' 11 %
Q9H422 BXGT020469 Homeodomain-interacting protein kinase 3 reviewed Kinase HIPK3 Activity '=' 9 %
P49759 BXGT010734 Dual specificity protein kinase CLK1 reviewed Kinase CLK1 Activity '=' 0 %
Q9BWU1 BXGT020156 Cyclin-dependent kinase 19 reviewed Kinase CDK19 Activity '=' 83 %
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Inhibition - - -
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A FC '=' 2 -
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 56 nM
O76039 BXGT005171 Cyclin-dependent kinase-like 5 reviewed Kinase CDKL5 Activity '=' 100 %
Q8NEB9 BXGT018553 Phosphatidylinositol 3-kinase catalytic subunit type 3 reviewed Kinase PIK3C3 Activity '=' 13 %
Q8TBX8 BXGT018791 Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma reviewed Kinase PIP4K2C Activity '=' 36 %
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Activity '=' 45 %
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A IC50 '=' 48 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 '>' 1000 nM
O14578 BXGT004072 Citron Rho-interacting kinase reviewed Kinase CIT Activity '=' 29 %
Q9UIK4 BXGT021720 Death-associated protein kinase 2 reviewed Kinase DAPK2 Activity '=' 72 %
Q8TF76 BXGT018826 Serine/threonine-protein kinase haspin reviewed Kinase HASPIN Activity '=' 2 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00823 Fruits Fruits
BXGF01008 Peganum harmala Peganum harmala Medicinal Plant
BXGF04966 Symplocos setchuensis Symplocos setchuensis Others
BXGF05158 Elaeagnus angustifolia Elaeagnus angustifolia Medicinal Plant
BXGF05837 Tribulus terrestris Tribulus terrestris Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease