Showing entry for D-Glutamate


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0036476
Compound NameD-Glutamate
Structure
FormulaC5H9NO4
InchiKeyWHUUTDBJXJRKMK-GSVOUGTGSA-N
SMILESOC(=O)CC[C@H](C(=O)O)N
InchiInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
IUPAC(2R)-2-aminopentanedioic acid
Molecular Weight147.05
Pubchem Id23327
Chembl IdCHEMBL76232
Targets of Information Source
DrugBank DB02517
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P43133 BXGT010359 Thermolysin reviewed - nprS experimental -
PDB DGL
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P41052 BXGT010221 Membrane-bound lytic murein transglycosylase B reviewed mltB - - - - -
P00800 BXGT005661 Thermolysin reviewed npr - - - - -
P94556 BXGT012138 Glutamate racemase 1 reviewed racE - - - - -
Q81UL8 BXGT017371 Glutamate racemase unreviewed racE1 - - - - -
A0A0J1HKB2 BXGT000499 Glutamate racemase unreviewed racE2 - - - - -
P15057 BXGT008076 Lysozyme reviewed CPL1 - - - - -
Q836J0 BXGT017467 Glutamate racemase reviewed murI - - - - -
Q6GHT5 BXGT016309 Glutamate racemase reviewed murI - - - - -
Q9ZLT0 BXGT022468 Glutamate racemase reviewed murI - - - - -
P56254 BXGT011160 Kalata-B1 reviewed OAK1 - - - - -
P01308 BXGT005749 Insulin reviewed INS - - - - -
Q736M3 BXGT016774 Gamma-D-glutamyl-L-lysine dipeptidyl-peptidase reviewed ykfC - - - - -
Q8A861 BXGT017860 L-Ala-D/L-Glu epimerase reviewed BT_1313 - - - - -
Q8IIS0 BXGT018280 D-aminoacyl-tRNA deacylase reviewed dtd - - - - -
Q62645 BXGT016035 Glutamate receptor ionotropic, NMDA 2D reviewed Grin2d - - - - -
Q5NFN6 BXGT015587 Glutamate racemase unreviewed murI - - - - -
Q9GK12 BXGT020403 Peptidoglycan recognition protein 1 reviewed PGLYRP1 - - - - -
B0TZW0 BXGT001861 L-amino acid-D/L-Glu epimerase reviewed Fphi_1647 - - - - -
P02640 BXGT005907 Villin-1 reviewed VIL1 - - - - -
O53223 BXGT004700 L,D-transpeptidase 2 reviewed ldtB - - - - -
Q9PM24 BXGT021336 Glutamate racemase reviewed murI - - - - -
Q4Q159 BXGT014860 Cysteine synthase unreviewed LMJF_36_3590 - - - - -
Q9HVZ7 BXGT020627 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase unreviewed murF - - - - -
Q6NY42 BXGT016435 Folate gamma-glutamyl hydrolase unreviewed ggh - - - - -
Q9Y606 BXGT022312 tRNA pseudouridine synthase A reviewed PUS1 Enzyme - - - -
Q948Z4 BXGT019557 Snakin-1 reviewed SN1 - - - - -
P62987 BXGT011478 Ubiquitin-60S ribosomal protein L40 reviewed UBA52 Nucleic acid binding - - - -
P9WPW9 BXGT012473 Glutamate racemase reviewed murI - - - - -
A0R1X0 BXGT000934 Glutamate racemase reviewed murI - - - - -
P22629 BXGT008788 Streptavidin reviewed - - - - -
Q9RBQ1 BXGT021439 Beta-lactamase unreviewed blaL2 - 0.084 - - -
A0A1J1ER74 BXGT000728 Glutamate racemase unreviewed murI - - - - -
K2K6A3 BXGT003773 Glutamate racemase unreviewed murI - - - - -
Q9RNB4 BXGT021477 McyF unreviewed mcyF - - - - -
P0CG47 BXGT007467 Polyubiquitin-B reviewed UBB Nucleic acid binding - - - -
Q9HZI6 BXGT020676 Probable soluble lytic transglycosylase unreviewed PA3020 - - - - -
Q10Z45 BXGT013214 Extracellular solute-binding protein, family 1 unreviewed Tery_3377 - - - - -
A9W3S0 BXGT025527 Tungsten-containing formylmethanofuran dehydrogenase, subunit B unreviewed Mext_1827 - - - - -
A9W3R7 BXGT025528 Formylmethanofuran dehydrogenase subunit C unreviewed Mext_1824 - - - - -
A9W3R8 BXGT025529 Formylmethanofuran--tetrahydromethanopterin formyltransferase unreviewed ffsA - - - - -
A9W3R9 BXGT025526 Formylmethanofuran dehydrogenase subunit A unreviewed Mext_1826 - - - - -
Binding DB 26431
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009831 Glutamate receptor ionotropic, NMDA 1 reviewed Grin1 8100 - - -
reviewed BXGT009831 Glutamate receptor ionotropic, NMDA 1 reviewed Grin1 8600 - - -
reviewed BXGT009831 Glutamate receptor ionotropic, NMDA 1 reviewed Grin1 9600 - - -
reviewed BXGT012717 Glutamate racemase reviewed murI 56000 - - -
reviewed BXGT012717 Glutamate racemase reviewed murI 190000 - - -
reviewed BXGT013468 Metabotropic glutamate receptor 2 reviewed G-protein coupled receptor GRM2 - - - 18250
reviewed BXGT009541 Metabotropic glutamate receptor 4 reviewed Grm4 - - - 12570
reviewed BXGT009815 Metabotropic glutamate receptor 6 reviewed Grm6 - - - 82210
reviewed BXGT009826 Metabotropic glutamate receptor 7 reviewed Grm7 - - - >100000
reviewed BXGT011675 Metabotropic glutamate receptor 8 reviewed Grm8 - - - 21470
reviewed BXGT008861 Metabotropic glutamate receptor 1 reviewed Grm1 - - - 23160
reviewed BXGT009542 Metabotropic glutamate receptor 5 reviewed Grm5 - - - 13650
reviewed BXGT010093 Glutamate receptor ionotropic, kainate 1 reviewed Ion channel GRIK1 - - - 75000
reviewed BXGT013303 Glutamate receptor ionotropic, kainate 2 reviewed Ion channel GRIK2 - - - 25000
reviewed BXGT013303 Glutamate receptor ionotropic, kainate 2 reviewed Ion channel GRIK2 1106 - - -
reviewed BXGT010294 Glutamate receptor 2 reviewed Ion channel GRIA2 940 - - -
reviewed BXGT010293 Glutamate receptor 1 reviewed Ion channel GRIA1 1362 - - -
reviewed BXGT013304 Glutamate receptor ionotropic, kainate 3 reviewed Ion channel GRIK3 789 - - -
reviewed BXGT010093 Glutamate receptor ionotropic, kainate 1 reviewed Ion channel GRIK1 701 - - -
reviewed BXGT010614 Glutamate receptor 4 reviewed Ion channel GRIA4 868 - - -
reviewed BXGT013630 Glutamate receptor ionotropic, kainate 5 reviewed Ion channel GRIK5 750 - - -
reviewed BXGT008861 Metabotropic glutamate receptor 1 reviewed Grm1 - - - 10000
reviewed BXGT009541 Metabotropic glutamate receptor 4 reviewed Grm4 - - - 12000
reviewed BXGT013468 Metabotropic glutamate receptor 2 reviewed G-protein coupled receptor GRM2 - - - 4000
reviewed BXGT009542 Metabotropic glutamate receptor 5 reviewed Grm5 - - - 4400
reviewed BXGT010292 Glutamate receptor ionotropic, kainate 2 reviewed Grik2 3280 - - -
reviewed BXGT010093 Glutamate receptor ionotropic, kainate 1 reviewed Ion channel GRIK1 - - - 22000
reviewed BXGT013332 Metabotropic glutamate receptor 1 reviewed G-protein coupled receptor GRM1 - - - >1000000
reviewed BXGT004150 Metabotropic glutamate receptor 6 reviewed G-protein coupled receptor GRM6 - - - >1000000
reviewed BXGT013468 Metabotropic glutamate receptor 2 reviewed G-protein coupled receptor GRM2 - - - >1000000
reviewed BXGT009826 Metabotropic glutamate receptor 7 reviewed Grm7 - - - 5400000
reviewed BXGT009540 Metabotropic glutamate receptor 3 reviewed Grm3 - - - 9000
reviewed BXGT009815 Metabotropic glutamate receptor 6 reviewed Grm6 - - - 20000
reviewed BXGT010266 Metabotropic glutamate receptor 5 reviewed G-protein coupled receptor GRM5 - - - 3100
reviewed BXGT004150 Metabotropic glutamate receptor 6 reviewed G-protein coupled receptor GRM6 - - - 4900
reviewed BXGT013468 Metabotropic glutamate receptor 2 reviewed G-protein coupled receptor GRM2 - - - 290
reviewed BXGT013332 Metabotropic glutamate receptor 1 reviewed G-protein coupled receptor GRM1 - - - 4900
reviewed BXGT013508 Metabotropic glutamate receptor 4 reviewed G-protein coupled receptor GRM4 - - - 9800
reviewed BXGT008861 Metabotropic glutamate receptor 1 reviewed Grm1 340 - - -
reviewed BXGT013468 Metabotropic glutamate receptor 2 reviewed G-protein coupled receptor GRM2 1200 - - -
reviewed BXGT013508 Metabotropic glutamate receptor 4 reviewed G-protein coupled receptor GRM4 1600 - - -
reviewed BXGT011141 Glutamate racemase reviewed murI 5800 - - -
reviewed BXGT010266 Metabotropic glutamate receptor 5 reviewed G-protein coupled receptor GRM5 - - - 631000
reviewed BXGT004150 Metabotropic glutamate receptor 6 reviewed G-protein coupled receptor GRM6 - - - 270000
reviewed BXGT009541 Metabotropic glutamate receptor 4 reviewed Grm4 - - - 2880
reviewed BXGT013468 Metabotropic glutamate receptor 2 reviewed G-protein coupled receptor GRM2 - - - 12589.25
reviewed BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO reviewed FTO - >1000000 - -
CHEMBL CHEMBL76232
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 4466 nM
P23385 BXGT008861 Metabotropic glutamate receptor 1 reviewed - Grm1 EC50 '=' 10000 nM
P31422 BXGT009540 Metabotropic glutamate receptor 3 reviewed - Grm3 EC50 '=' 9000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 25118 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 44668 nM
P31424 BXGT009542 Metabotropic glutamate receptor 5 reviewed - Grm5 EC50 '=' 4400 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 31622 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 10000 nM
P31423 BXGT009541 Metabotropic glutamate receptor 4 reviewed - Grm4 EC50 '<' 100000 nM
Q836J0 BXGT017467 Glutamate racemase reviewed - murI Km '=' 250000 nM
Q03469 BXGT012717 Glutamate racemase reviewed - murI Km '=' 300000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 25118 nM
P56068 BXGT011141 Glutamate racemase reviewed - murI Kcat '=' 5 /min
P19490 BXGT008488 Glutamate receptor 1 reviewed - Gria1 IC50 '~' 100000 nM
P19493 BXGT008491 Glutamate receptor 4 reviewed - Gria4 IC50 '~' 100000 nM
P19492 BXGT008490 Glutamate receptor 3 reviewed - Gria3 IC50 '~' 100000 nM
P19491 BXGT008489 Glutamate receptor 2 reviewed - Gria2 IC50 '~' 100000 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 56234 nM
Q03469 BXGT012717 Glutamate racemase reviewed - murI Ki '=' 56000 nM
Q14833 BXGT013508 Metabotropic glutamate receptor 4 reviewed G-protein coupled receptor GRM4 EC50 '=' - -
P56068 BXGT011141 Glutamate racemase reviewed - murI Km '=' 63000 nM
Q13255 BXGT013332 Metabotropic glutamate receptor 1 reviewed G-protein coupled receptor GRM1 EC50 '>' 1000000 nM
P56068 BXGT011141 Glutamate racemase reviewed - murI Kcat '=' 12 /min
P56068 BXGT011141 Glutamate racemase reviewed - murI Km '=' 275000 nM
Q63273 BXGT016064 Glutamate receptor ionotropic, kainate 5 reviewed - Grik5 IC50 '=' 78000 nM
P42264 BXGT010296 Glutamate receptor ionotropic, kainate 3 reviewed - Grik3 IC50 '=' 78000 nM
P42260 BXGT010292 Glutamate receptor ionotropic, kainate 2 reviewed - Grik2 IC50 '=' 78000 nM
Q01812 BXGT012617 Glutamate receptor ionotropic, kainate 4 reviewed - Grik4 IC50 '=' 78000 nM
P22756 BXGT008804 Glutamate receptor ionotropic, kainate 1 reviewed - Grik1 IC50 '=' 78000 nM
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM Potency '=' 5 nM
Q14416 BXGT013468 Metabotropic glutamate receptor 2 reviewed G-protein coupled receptor GRM2 EC50 '>' 1000000 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 31622 nM
Q4CVY4 BXGT026093 Carbonic anhydrase-like protein, putative unreviewed - Tc00.1047053509597.20 KA '>' 100 uM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 15848 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 12589 nM
P35349 BXGT009815 Metabotropic glutamate receptor 6 reviewed - Grm6 EC50 '=' 20000 nM
P35400 BXGT009826 Metabotropic glutamate receptor 7 reviewed - Grm7 EC50 '=' 5400000 nM
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO reviewed - FTO IC50 '>' 1000000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q03469 BXGT012717 Glutamate racemase reviewed - murI Ki '=' 190000 nM
P56068 BXGT011141 Glutamate racemase reviewed - murI Ki '=' 661000 nM
P56068 BXGT011141 Glutamate racemase reviewed - murI Km '=' 282000 nM
P56068 BXGT011141 Glutamate racemase reviewed - murI Ki '>' 100000000 nM
P31421 BXGT009539 Metabotropic glutamate receptor 2 reviewed - Grm2 EC50 '=' 4000 nM
P56068 BXGT011141 Glutamate racemase reviewed - murI Kcat '=' 3 /min
Q836J0 BXGT017467 Glutamate racemase reviewed - murI Kcat '=' 704 /min
P56068 BXGT011141 Glutamate racemase reviewed - murI Ki '=' 5800 nM
O15303 BXGT004150 Metabotropic glutamate receptor 6 reviewed G-protein coupled receptor GRM6 EC50 '>' 1000000 nM
P31423 BXGT009541 Metabotropic glutamate receptor 4 reviewed - Grm4 EC50 '=' 12000 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 39810 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 KA '=' 10 uM
P9WPW9 BXGT012473 Glutamate racemase reviewed - murI Delta Tm '=' 2 degrees C
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 KA '>' 100 uM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00008 Garlic Allium sativum Herbs and Spices
BXGF00027 Chinese mustard Brassica juncea Vegetables
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF01771 Achyranthes fauriei Achyranthes fauriei Medicinal Plant
BXGF01960 Achyranthes bidentata Achyranthes bidentata Medicinal Plant
BXGF03608 Achyranthes japonica Achyranthes japonica Medicinal Plant
BXGF05421 Tussilago farfara Tussilago farfara Medicinal Plant
BXGF05511 Acorus gramineus Acorus gramineus Medicinal Plant
BXGF06071 Acorus tatarinowii Acorus tatarinowii Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease