acompound

Showing entry for Quisqualate

General Compound Information
BXGC Id	BXGC0036441
Compound Name	Quisqualate
Structure
Formula	C5H7N3O5
InchiKey	ASNFTDCKZKHJSW-REOHCLBHSA-N
SMILES	OC(=O)[C@H](Cn1oc(=O)nc1O)N
Inchi	InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
IUPAC	(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Molecular Weight	189.04
Pubchem Id	40539
Chembl Id	CHEMBL279956

Targets of Information Source

DrugBank

DB02999

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
P42262	BXGT010294	Glutamate receptor 2	reviewed	Ion channel	GRIA2	experimental	-
Q13002	BXGT013303	Glutamate receptor ionotropic, kainate 2	reviewed	Ion channel	GRIK2	experimental	-

PDB

QUS

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
P19491	BXGT008489	Glutamate receptor 2	reviewed	Gria2	-	-	20	-	-
P19491	BXGT008489	Glutamate receptor 2	reviewed	Gria2	-	-	-	1740	-
P42260	BXGT010292	Glutamate receptor ionotropic, kainate 2	reviewed	Grik2	-	253	-	-	-
P19491	BXGT008489	Glutamate receptor 2	reviewed	Gria2	-	-	-	-	-
Q04609	BXGT012768	Glutamate carboxypeptidase 2	reviewed	FOLH1	Enzyme	-	-	-	-
Q04609	BXGT012768	Glutamate carboxypeptidase 2	reviewed	FOLH1	Enzyme	-	9500	-	-
Q9Y3Q0	BXGT022263	N-acetylated-alpha-linked acidic dipeptidase 2	reviewed	NAALAD2	Enzyme	230	-	-	-
P19492	BXGT008490	Glutamate receptor 3	reviewed	Gria3	-	168	-	-	-
P19492	BXGT008490	Glutamate receptor 3	reviewed	Gria3	-	42	-	-	-
P41594	BXGT010266	Metabotropic glutamate receptor 5	reviewed	GRM5	G-protein coupled receptor	-	-	-	-

Binding DB

17660

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT009831	Glutamate receptor ionotropic, NMDA 1	reviewed		Grin1	>10000	-	-	-
reviewed	BXGT009831	Glutamate receptor ionotropic, NMDA 1	reviewed		Grin1	260	-	-	-
reviewed	BXGT013620	Glutamate receptor ionotropic, kainate 4	reviewed	Ion channel	GRIK4	6.43	-	-	-
reviewed	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	30	-	-	-
reviewed	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	420	-	-	-
reviewed	BXGT013507	Metabotropic glutamate receptor 3	reviewed	G-protein coupled receptor	GRM3	250	-	-	-
reviewed	BXGT013507	Metabotropic glutamate receptor 3	reviewed	G-protein coupled receptor	GRM3	6000	-	-	-
reviewed	BXGT013507	Metabotropic glutamate receptor 3	reviewed	G-protein coupled receptor	GRM3	>10000	-	-	-
reviewed	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	>10000	-	-	-
reviewed	BXGT009541	Metabotropic glutamate receptor 4	reviewed		Grm4	>10000	-	-	-
reviewed	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	200	-	-	-
reviewed	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	>10000	-	-	-
reviewed	BXGT010266	Metabotropic glutamate receptor 5	reviewed	G-protein coupled receptor	GRM5	30	-	-	-
reviewed	BXGT004150	Metabotropic glutamate receptor 6	reviewed	G-protein coupled receptor	GRM6	>10000	-	-	-
reviewed	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	178	-	-	-
reviewed	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	10	-	-	-
reviewed	BXGT010266	Metabotropic glutamate receptor 5	reviewed	G-protein coupled receptor	GRM5	29	-	-	-
reviewed	BXGT008490	Glutamate receptor 3	reviewed		Gria3	>10000	-	-	-
reviewed	BXGT008861	Metabotropic glutamate receptor 1	reviewed		Grm1	-	-	-	750
reviewed	BXGT009542	Metabotropic glutamate receptor 5	reviewed		Grm5	-	-	-	200
reviewed	BXGT008861	Metabotropic glutamate receptor 1	reviewed		Grm1	-	-	-	16400
reviewed	BXGT009541	Metabotropic glutamate receptor 4	reviewed		Grm4	-	-	-	>100000
reviewed	BXGT008861	Metabotropic glutamate receptor 1	reviewed		Grm1	-	-	-	700
reviewed	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	-	-	-	>500000
reviewed	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	-	-	-	200
reviewed	BXGT021803	Cystine/glutamate transporter	reviewed	Transporter	SLC7A11	-	5000	-	-
reviewed	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	-	-	-	>1000000
reviewed	BXGT010580	Metabotropic glutamate receptor 8	reviewed		Grm8	-	-	-	>100000
reviewed	BXGT010266	Metabotropic glutamate receptor 5	reviewed	G-protein coupled receptor	GRM5	-	-	-	150
reviewed	BXGT009826	Metabotropic glutamate receptor 7	reviewed		Grm7	-	-	-	>1000000
reviewed	BXGT009540	Metabotropic glutamate receptor 3	reviewed		Grm3	-	-	-	40000
reviewed	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	-	-	-	>500000
reviewed	BXGT008861	Metabotropic glutamate receptor 1	reviewed		Grm1	-	-	-	2500
reviewed	BXGT009815	Metabotropic glutamate receptor 6	reviewed		Grm6	-	-	-	1000000
reviewed	BXGT013506	Metabotropic glutamate receptor 7	reviewed	G-protein coupled receptor	GRM7	-	-	-	>1000000
reviewed	BXGT004150	Metabotropic glutamate receptor 6	reviewed	G-protein coupled receptor	GRM6	1000000	-	-	-
reviewed	BXGT010266	Metabotropic glutamate receptor 5	reviewed	G-protein coupled receptor	GRM5	55	-	-	-
reviewed	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	1100	-	-	-
reviewed	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	1000000	-	-	-
reviewed	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	>1000000	-	-	-
reviewed	BXGT013507	Metabotropic glutamate receptor 3	reviewed	G-protein coupled receptor	GRM3	40000	-	-	-
reviewed	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	112000	-	-	-
reviewed	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	113000	-	-	-
reviewed	BXGT008861	Metabotropic glutamate receptor 1	reviewed		Grm1	10	-	-	-
reviewed	BXGT010296	Glutamate receptor ionotropic, kainate 3	reviewed		Grik3	1670	-	-	-
reviewed	BXGT008804	Glutamate receptor ionotropic, kainate 1	reviewed		Grik1	171	-	-	-
reviewed	BXGT010292	Glutamate receptor ionotropic, kainate 2	reviewed		Grik2	134	-	-	-

CHEMBL

CHEMBL279956

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P19490	BXGT008488	Glutamate receptor 1	reviewed	-	Gria1	IC50	'='	7000	nM
P19493	BXGT008491	Glutamate receptor 4	reviewed	-	Gria4	IC50	'='	7000	nM
P19492	BXGT008490	Glutamate receptor 3	reviewed	-	Gria3	IC50	'='	7000	nM
P19491	BXGT008489	Glutamate receptor 2	reviewed	-	Gria2	IC50	'='	7000	nM
Q9Z2W9	BXGT022414	Glutamate receptor 3	reviewed	-	Gria3	IC50	'='	80	nM
Q9Z2W8	BXGT022413	Glutamate receptor 4	reviewed	-	Gria4	IC50	'='	80	nM
P23818	BXGT008911	Glutamate receptor 1	reviewed	-	Gria1	IC50	'='	80	nM
P23819	BXGT008912	Glutamate receptor 2	reviewed	-	Gria2	IC50	'='	80	nM
Q14832	BXGT013507	Metabotropic glutamate receptor 3	reviewed	G-protein coupled receptor	GRM3	Ki	'='	40000	nM
P23385	BXGT008861	Metabotropic glutamate receptor 1	reviewed	-	Grm1	EC50	'='	700	nM
P31422	BXGT009540	Metabotropic glutamate receptor 3	reviewed	-	Grm3	EC50	'='	40000	nM
Q14833	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	EC50	'>'	500000	nM
P31424	BXGT009542	Metabotropic glutamate receptor 5	reviewed	-	Grm5	EC50	'='	200	nM
P54132	BXGT011032	Bloom syndrome protein	reviewed	-	BLM	Potency	'='	2	nM
P42260	BXGT010292	Glutamate receptor ionotropic, kainate 2	reviewed	-	Grik2	Ki	'='	131	nM
P42260	BXGT010292	Glutamate receptor ionotropic, kainate 2	reviewed	-	Grik2	Ki	'='	134	nM
Q14833	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	Ki	'='	112000	nM
P19490	BXGT008488	Glutamate receptor 1	reviewed	-	Gria1	IC50	'='	1300	nM
P19493	BXGT008491	Glutamate receptor 4	reviewed	-	Gria4	IC50	'='	1300	nM
P19492	BXGT008490	Glutamate receptor 3	reviewed	-	Gria3	IC50	'='	1300	nM
P19491	BXGT008489	Glutamate receptor 2	reviewed	-	Gria2	IC50	'='	1300	nM
O15303	BXGT004150	Metabotropic glutamate receptor 6	reviewed	G-protein coupled receptor	GRM6	Ki	'='	1000000	nM
Q9UPY5	BXGT021803	Cystine/glutamate transporter	reviewed	Transporter	SLC7A11	IC50	'='	5000	nM
P23385	BXGT008861	Metabotropic glutamate receptor 1	reviewed	-	Grm1	EC50 ratio	'='	0	-
Q13255	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	Ki	'='	1100	nM
Q14416	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	Ki	'>'	1000000	nM
P0A6C1	BXGT007045	Endonuclease 4	reviewed	-	nfo	Potency	'='	44668	nM
P42264	BXGT010296	Glutamate receptor ionotropic, kainate 3	reviewed	-	Grik3	Ki	'='	1670	nM
O75164	BXGT005104	Lysine-specific demethylase 4A	reviewed	-	KDM4A	Potency	-	3981	nM
Q14416	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	EC50	'>'	1000000	nM
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	39810	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	39810	nM
P00352	BXGT005510	Retinal dehydrogenase 1	reviewed	Enzyme	ALDH1A1	Potency	'='	8912	nM
P42264	BXGT010296	Glutamate receptor ionotropic, kainate 3	reviewed	-	Grik3	Ki	'='	1380	nM
P23385	BXGT008861	Metabotropic glutamate receptor 1	reviewed	-	Grm1	EC50	'='	2500	nM
Q13255	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	Ratio	'='	0	-
Q14831	BXGT013506	Metabotropic glutamate receptor 7	reviewed	G-protein coupled receptor	GRM7	EC50	'>'	1000000	nM
Q04609	BXGT012768	Glutamate carboxypeptidase 2	reviewed	Enzyme	FOLH1	IC50	'='	9500	nM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Potency	'='	1000	nM
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	10000	nM
Q9F4F7	BXGT020344	4'-phosphopantetheinyl transferase ffp	reviewed	-	ffp	Potency	'='	89125	nM
P31423	BXGT009541	Metabotropic glutamate receptor 4	reviewed	-	Grm4	EC50	'='	129000	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	'='	3	nM
Q14416	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	Ki	'='	113000	nM
Q99549	BXGT019932	M-phase phosphoprotein 8	reviewed	Epigenetic regulator	MPHOSPH8	Potency	-	794	nM
P23385	BXGT008861	Metabotropic glutamate receptor 1	reviewed	-	Grm1	EC50	'='	200	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Potency	'='	19952	nM
P31421	BXGT009539	Metabotropic glutamate receptor 2	reviewed	-	Grm2	EC50 ratio	'>'	90	-
P31424	BXGT009542	Metabotropic glutamate receptor 5	reviewed	-	Grm5	EC50	'='	300	nM
P35349	BXGT009815	Metabotropic glutamate receptor 6	reviewed	-	Grm6	EC50	'='	1000000	nM
Q13255	BXGT013332	Metabotropic glutamate receptor 1	reviewed	G-protein coupled receptor	GRM1	EC50	'='	200	nM
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	reviewed	Transcription factor	NFKB1	Potency	'='	10	nM
P10635	BXGT007595	Cytochrome P450 2D6	reviewed	-	CYP2D6	AC50	-	-	-
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	23	%
Q9UBT6	BXGT021664	DNA polymerase kappa	reviewed	-	POLK	Potency	-	1000	nM
P33261	BXGT009707	Cytochrome P450 2C19	reviewed	-	CYP2C19	AC50	-	-	-
Q14833	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	Ki	'='	1000000	nM
P23385	BXGT008861	Metabotropic glutamate receptor 1	reviewed	-	Grm1	Ki	'='	10	nM
P23385	BXGT008861	Metabotropic glutamate receptor 1	reviewed	-	Grm1	EC50	'='	16400	nM
B2RXH2	BXGT002006	Lysine-specific demethylase 4E	reviewed	-	KDM4E	Potency	'='	10000	nM
Q9F4F7	BXGT020344	4'-phosphopantetheinyl transferase ffp	reviewed	-	ffp	Potency	'='	44668	nM
Q14416	BXGT013468	Metabotropic glutamate receptor 2	reviewed	G-protein coupled receptor	GRM2	Ratio	'='	108	-
Q14833	BXGT013508	Metabotropic glutamate receptor 4	reviewed	G-protein coupled receptor	GRM4	Ratio	'='	593	-
P31423	BXGT009541	Metabotropic glutamate receptor 4	reviewed	-	Grm4	EC50	'>'	100000	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	1000	nM
P08482	BXGT006775	Muscarinic acetylcholine receptor M1	reviewed	-	Chrm1	Potency	'='	17	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	707	nM
P47743	BXGT010580	Metabotropic glutamate receptor 8	reviewed	-	Grm8	EC50	'>'	100000	nM
P31421	BXGT009539	Metabotropic glutamate receptor 2	reviewed	-	Grm2	EC50	'>'	1000000	nM
P41594	BXGT010266	Metabotropic glutamate receptor 5	reviewed	G-protein coupled receptor	GRM5	Ki	'='	55	nM
P05177	BXGT006336	Cytochrome P450 1A2	reviewed	Enzyme	CYP1A2	AC50	'='	39810	nM
Q194T2	BXGT013743	Non-structural protein 1	unreviewed	-	NS1	Potency	'='	5011	nM
P23385	BXGT008861	Metabotropic glutamate receptor 1	reviewed	-	Grm1	EC50	'='	750	nM
P31421	BXGT009539	Metabotropic glutamate receptor 2	reviewed	-	Grm2	EC50	'>'	500000	nM
P35400	BXGT009826	Metabotropic glutamate receptor 7	reviewed	-	Grm7	EC50	'>'	1000000	nM
O89049	BXGT005293	Thioredoxin reductase 1, cytoplasmic	reviewed	-	Txnrd1	Potency	-	4744	nM
P49798	BXGT010745	Regulator of G-protein signaling 4	reviewed	Enzyme modulator	RGS4	Potency	-	946	nM
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	AC50	'='	1000	nM
P11712	BXGT007738	Cytochrome P450 2C9	reviewed	-	CYP2C9	AC50	-	-	-
Q63273	BXGT016064	Glutamate receptor ionotropic, kainate 5	reviewed	-	Grik5	IC50	'='	150	nM
P42264	BXGT010296	Glutamate receptor ionotropic, kainate 3	reviewed	-	Grik3	IC50	'='	150	nM
P42260	BXGT010292	Glutamate receptor ionotropic, kainate 2	reviewed	-	Grik2	IC50	'='	150	nM
Q01812	BXGT012617	Glutamate receptor ionotropic, kainate 4	reviewed	-	Grik4	IC50	'='	150	nM
P22756	BXGT008804	Glutamate receptor ionotropic, kainate 1	reviewed	-	Grik1	IC50	'='	150	nM
P41594	BXGT010266	Metabotropic glutamate receptor 5	reviewed	G-protein coupled receptor	GRM5	EC50	'='	150	nM
P22756	BXGT008804	Glutamate receptor ionotropic, kainate 1	reviewed	-	Grik1	Ki	'='	171	nM
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	2	%
Q9R1M7	BXGT021417	Glutamate receptor ionotropic, NMDA 3A	reviewed	-	Grin3a	IC50	'>'	100000	nM
Q8VHN2	BXGT018931	Glutamate receptor ionotropic, NMDA 3B	reviewed	-	Grin3b	IC50	'>'	100000	nM
Q62645	BXGT016035	Glutamate receptor ionotropic, NMDA 2D	reviewed	-	Grin2d	IC50	'>'	100000	nM
Q00961	BXGT012556	Glutamate receptor ionotropic, NMDA 2C	reviewed	-	Grin2c	IC50	'>'	100000	nM
Q00960	BXGT012555	Glutamate receptor ionotropic, NMDA 2B	reviewed	-	Grin2b	IC50	'>'	100000	nM
Q00959	BXGT012554	Glutamate receptor ionotropic, NMDA 2A	reviewed	-	Grin2a	IC50	'>'	100000	nM
P35439	BXGT009831	Glutamate receptor ionotropic, NMDA 1	reviewed	-	Grin1	IC50	'>'	100000	nM
P28482	BXGT009263	Mitogen-activated protein kinase 1	reviewed	Kinase	MAPK1	Potency	'='	12589	nM
Q9Z1J7	BXGT022405	Amino acid transporter	unreviewed	-	Slc1a5	Inhibition	'>='	25	%
P83916	BXGT012025	Chromobox protein homolog 1	reviewed	Epigenetic regulator	CBX1	Potency	-	31622	nM
P31424	BXGT009542	Metabotropic glutamate receptor 5	reviewed	-	Grm5	EC80	'='	100	nM
P22756	BXGT008804	Glutamate receptor ionotropic, kainate 1	reviewed	-	Grik1	Ki	'='	169	nM
O94782	BXGT005332	Ubiquitin carboxyl-terminal hydrolase 1	reviewed	Enzyme	USP1	Potency	-	2993	nM
P15289	BXGT008102	Arylsulfatase A	reviewed	Enzyme	ARSA	Potency	-	23934	nM
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	35481	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF03199	Combretum indicum	Combretum indicum	Medicinal Plant
BXGF03267	Thalictrum simplex	Thalictrum simplex	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}