Showing entry for Lys-63-specific deubiquitinase BRCC36


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010538
Protein NameLys-63-specific deubiquitinase BRCC36
Uniport IdP46736
GeneBRCC3
Gene Id79184
DomainBRCC36_C; JAB
Pfam PF18110   PF01398  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03440 Homologous recombination
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0051301 cell division
Biological Process GO:0006281 DNA repair
Biological Process GO:0006302 double-strand break repair
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0070537 histone H2A K63-linked deubiquitination
Biological Process GO:0045739 positive regulation of DNA repair
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0070536 protein K63-linked deubiquitination
Biological Process GO:0010212 response to ionizing radiation
Biological Process GO:0010165 response to X-ray
Biological Process GO:0072425 signal transduction involved in G2 DNA damage checkpoint
molecular function GO:0030234 enzyme regulator activity
molecular function GO:0070122 isopeptidase activity
molecular function GO:0061578 Lys63-specific deubiquitinase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0008237 metallopeptidase activity
molecular function GO:0031593 polyubiquitin modification-dependent protein binding
molecular function GO:0004843 thiol-dependent ubiquitin-specific protease activity
molecular function GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
cellular component GO:0070531 BRCA1-A complex
cellular component GO:0070552 BRISC complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0000152 nuclear ubiquitin ligase complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000922 spindle pole
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-392499 Metabolism of proteins
R-HSA-5688426 Deubiquitination
R-HSA-5689901 Metalloprotease DUBs
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693538 Homology Directed Repair
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-5693606 DNA Double Strand Break Response
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-597592 Post-translational protein modification
R-HSA-69473 G2/M DNA damage checkpoint
R-HSA-69481 G2/M Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0013238 BXGD000806 Dry Eye Syndromes Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0272322 BXGD006343 Severe hereditary factor VIII deficiency disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0314719 BXGD006890 Dryness of eye Eye Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1301355 BXGD012287 Myelodysplastic-Myeloproliferative Diseases Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2955673 BXGD018191 Urate nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3151857 BXGD018451 MOYAMOYA DISEASE 4 WITH SHORT STATURE, HYPERGONADOTROPIC HYPOGONADISM, AND FACIAL DYSMORPHISM
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002682 Zinc 65.41
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein