Showing entry for MYELODYSPLASTIC SYNDROME



                               
General Disease Information
BXGD IdBXGD018899
Disease NameMYELODYSPLASTIC SYNDROME
Disease CUI IdC3463824
MeSH Codes C15  
Disease Class NameHemic and Lymphatic Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0002664   HP:0001871  
Human Phenotype Ontology TermNeoplasm; Abnormality of blood and blood-forming tissues
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00142 BXGT003883 Thymidine kinase 2, mitochondrial 7084 reviewed Kinase
O00182 BXGT003889 Galectin-9 3965 reviewed Signaling
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00429 BXGT003919 Dynamin-1-like protein 10059 reviewed Enzyme modulator
O00444 BXGT003921 Serine/threonine-protein kinase PLK4 10733 reviewed Kinase
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A 773 reviewed Ion channel
O14656 BXGT004080 Torsin-1A 1861 reviewed Chaperone
O14727 BXGT004084 Apoptotic protease-activating factor 1 317 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 1111 reviewed Kinase
O14763 BXGT004093 Tumor necrosis factor receptor superfamily member 10B 8795 reviewed
O14818 BXGT004103 Proteasome subunit alpha type-7 5688 reviewed
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O15054 BXGT004121 Lysine-specific demethylase 6B 23135 reviewed Epigenetic regulator
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15297 BXGT004149 Protein phosphatase 1D 8493 reviewed Enzyme
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O15392 BXGT004162 Baculoviral IAP repeat-containing protein 5 332 reviewed Enzyme modulator
O15527 BXGT004176 N-glycosylase/DNA lyase 4968 reviewed
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O15553 BXGT004181 Pyrin 4210 reviewed
O43293 BXGT004584 Death-associated protein kinase 3 1613 reviewed Kinase
O43324 BXGT004588 Eukaryotic translation elongation factor 1 epsilon-1 9521 reviewed
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O43683 BXGT004614 Mitotic checkpoint serine/threonine-protein kinase BUB1 699 reviewed Kinase
O43913 BXGT004634 Origin recognition complex subunit 5 5001 reviewed Nucleic acid binding
O60566 BXGT004884 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 701 reviewed Kinase
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75015 BXGT005095 Low affinity immunoglobulin gamma Fc region receptor III-B 2215 reviewed Cell adhesion
O75340 BXGT005112 Programmed cell death protein 6 10016 reviewed
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O75475 BXGT005130 PC4 and SFRS1-interacting protein 11168 reviewed Signaling
O75521 BXGT005134 Enoyl-CoA delta isomerase 2, mitochondrial 10455 reviewed Enzyme modulator
O75530 BXGT005135 Polycomb protein EED 8726 reviewed
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
O76082 BXGT005175 Solute carrier family 22 member 5 6584 reviewed Transporter
O76094 BXGT005177 Signal recognition particle subunit SRP72 6731 reviewed
O95390 BXGT005377 Growth/differentiation factor 11 10220 reviewed Signaling
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00558 BXGT005579 Phosphoglycerate kinase 1 5230 reviewed Kinase
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02724 BXGT005934 Glycophorin-A 2993 reviewed
P02765 BXGT005952 Alpha-2-HS-glycoprotein 197 reviewed Enzyme modulator
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03950 BXGT006116 Angiogenin 283 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04183 BXGT006166 Thymidine kinase, cytosolic 7083 reviewed Kinase
P04279 BXGT006183 Semenogelin-1 6406 reviewed
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04732 BXGT006252 Metallothionein-1E 4493 reviewed
P05089 BXGT006310 Arginase-1 383 reviewed Enzyme
P05106 BXGT006315 Integrin beta-3 3690 reviewed Receptor
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05230 BXGT006344 Fibroblast growth factor 1 2246 reviewed Signaling
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06276 BXGT006430 Cholinesterase 590 reviewed
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06744 BXGT006494 Glucose-6-phosphate isomerase 2821 reviewed Enzyme
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07333 BXGT006602 Macrophage colony-stimulating factor 1 receptor 1436 reviewed Kinase
P07355 BXGT006609 Annexin A2 302 reviewed
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P07477 BXGT006629 Trypsin-1 5644 reviewed Enzyme
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 1132 reviewed G-protein coupled receptor
P08174 BXGT006739 Complement decay-accelerating factor 1604 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08246 BXGT006756 Neutrophil elastase 1991 reviewed Enzyme
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08514 BXGT006781 Integrin alpha-IIb 3674 reviewed
P08572 BXGT006791 Collagen alpha-2(IV) chain 1284 reviewed
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08631 BXGT006801 Tyrosine-protein kinase HCK 3055 reviewed Kinase
P08637 BXGT006802 Low affinity immunoglobulin gamma Fc region receptor III-A 2214 reviewed Cell adhesion
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08700 BXGT006816 Interleukin-3 3562 reviewed
P08758 BXGT006821 Annexin A5 308 reviewed
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09486 BXGT006897 SPARC 6678 reviewed Signaling
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P09651 BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 3178 reviewed
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09914 BXGT006940 Interferon-induced protein with tetratricopeptide repeats 1 3434 reviewed
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P09923 BXGT006942 Intestinal-type alkaline phosphatase 248 reviewed Enzyme
P10144 BXGT007541 Granzyme B 3002 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10276 BXGT007553 Retinoic acid receptor alpha 5914 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P10997 BXGT007643 Islet amyloid polypeptide 3375 reviewed Signaling
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11308 BXGT007684 Transcriptional regulator ERG 2078 reviewed Transcription factor
P11388 BXGT007697 DNA topoisomerase 2-alpha 7153 reviewed
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12830 BXGT007852 Cadherin-1 999 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13612 BXGT007928 Integrin alpha-4 3676 reviewed
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14921 BXGT008068 Protein C-ets-1 2113 reviewed Transcription factor
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15531 BXGT008136 Nucleoside diphosphate kinase A 4830 reviewed Kinase
P15559 BXGT008139 NAD(P)H dehydrogenase [quinone] 1 1728 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15884 BXGT008166 Transcription factor 4 6925 reviewed Transcription factor
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16144 BXGT008200 Integrin beta-4 3691 reviewed Receptor
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16442 BXGT008227 Histo-blood group ABO system transferase 28 reviewed Enzyme
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P16581 BXGT008245 E-selectin 6401 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P17174 BXGT008289 Aspartate aminotransferase, cytoplasmic 2805 reviewed
P17252 BXGT008294 Protein kinase C alpha type 5578 reviewed Kinase
P17643 BXGT008323 5,6-dihydroxyindole-2-carboxylic acid oxidase 7306 reviewed Enzyme
P17936 BXGT008357 Insulin-like growth factor-binding protein 3 3486 reviewed Enzyme modulator
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18074 BXGT008374 General transcription and DNA repair factor IIH helicase subunit XPD 2068 reviewed Enzyme
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P18887 BXGT008437 DNA repair protein XRCC1 7515 reviewed
P19174 BXGT008467 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 5335 reviewed Enzyme
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P19525 BXGT008492 Interferon-induced, double-stranded RNA-activated protein kinase 5610 reviewed Kinase
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P20273 BXGT008557 B-cell receptor CD22 933 reviewed
P20810 BXGT008602 Calpastatin 831 reviewed
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P20815 BXGT008604 Cytochrome P450 3A5 1577 reviewed Enzyme
P21359 BXGT008640 Neurofibromin 4763 reviewed Enzyme modulator
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21583 BXGT008667 Kit ligand 4254 reviewed
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P22352 BXGT008758 Glutathione peroxidase 3 2878 reviewed Enzyme
P22557 BXGT008783 5-aminolevulinate synthase, erythroid-specific, mitochondrial 212 reviewed Enzyme
P22681 BXGT008795 E3 ubiquitin-protein ligase CBL 867 reviewed Enzyme
P22736 BXGT008800 Nuclear receptor subfamily 4 group A member 1 3164 reviewed Nuclear receptor
P22830 BXGT008809 Ferrochelatase, mitochondrial 2235 reviewed Enzyme
P23458 BXGT008868 Tyrosine-protein kinase JAK1 3716 reviewed Kinase
P23528 BXGT008879 Cofilin-1 1072 reviewed
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P23786 BXGT008906 Carnitine O-palmitoyltransferase 2, mitochondrial 1376 reviewed Enzyme
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P25311 BXGT009036 Zinc-alpha-2-glycoprotein 563 reviewed
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P26368 BXGT009106 Splicing factor U2AF 65 kDa subunit 11338 reviewed
P26951 BXGT009147 Interleukin-3 receptor subunit alpha 3563 reviewed Signaling
P27037 BXGT009153 Activin receptor type-2A 92 reviewed Kinase
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P27707 BXGT009201 Deoxycytidine kinase 1633 reviewed Kinase
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P27815 BXGT009208 cAMP-specific 3',5'-cyclic phosphodiesterase 4A 5141 reviewed
P28072 BXGT009231 Proteasome subunit beta type-6 5694 reviewed
P28222 BXGT009238 5-hydroxytryptamine receptor 1B 3351 reviewed G-protein coupled receptor
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28562 BXGT009270 Dual specificity protein phosphatase 1 1843 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29320 BXGT009332 Ephrin type-A receptor 3 2042 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29350 BXGT009335 Tyrosine-protein phosphatase non-receptor type 6 5777 reviewed
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30043 BXGT009394 Flavin reductase (NADPH) 645 reviewed Enzyme
P30101 BXGT009402 Protein disulfide-isomerase A3 2923 reviewed
P30281 BXGT009416 G1/S-specific cyclin-D3 896 reviewed Enzyme modulator
P30307 BXGT009421 M-phase inducer phosphatase 3 995 reviewed Enzyme
P30530 BXGT009431 Tyrosine-protein kinase receptor UFO 558 reviewed Kinase
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31350 BXGT009526 Ribonucleoside-diphosphate reductase subunit M2 6241 reviewed Enzyme
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31946 BXGT009588 14-3-3 protein beta/alpha 7529 reviewed Chaperone
P31997 BXGT009593 Carcinoembryonic antigen-related cell adhesion molecule 8 1088 reviewed
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P32320 BXGT009622 Cytidine deaminase 978 reviewed Enzyme
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35221 BXGT009798 Catenin alpha-1 1495 reviewed Cellular structure
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35499 BXGT009839 Sodium channel protein type 4 subunit alpha 6329 reviewed Ion channel
P35590 BXGT009854 Tyrosine-protein kinase receptor Tie-1 7075 reviewed Kinase
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35658 BXGT009859 Nuclear pore complex protein Nup214 8021 reviewed Nucleic acid binding
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 2322 reviewed Kinase
P36897 BXGT009941 TGF-beta receptor type-1 7046 reviewed Kinase
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P40337 BXGT010174 von Hippel-Lindau disease tumor suppressor 7428 reviewed Enzyme
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41145 BXGT010225 Kappa-type opioid receptor 4986 reviewed G-protein coupled receptor
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P41440 BXGT010261 Folate transporter 1 6573 reviewed Transporter
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43155 BXGT010363 Carnitine O-acetyltransferase 1384 reviewed Enzyme
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43351 BXGT010380 DNA repair protein RAD52 homolog 5893 reviewed Nucleic acid binding
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P43405 BXGT010386 Tyrosine-protein kinase SYK 6850 reviewed Kinase
P43489 BXGT010394 Tumor necrosis factor receptor superfamily member 4 7293 reviewed
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46736 BXGT010538 Lys-63-specific deubiquitinase BRCC36 79184 reviewed Enzyme
P47712 BXGT010577 Cytosolic phospholipase A2 5321 reviewed Enzyme
P47736 BXGT010579 Rap1 GTPase-activating protein 1 5909 reviewed Enzyme modulator
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48060 BXGT010615 Glioma pathogenesis-related protein 1 11010 reviewed Immune response
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P48426 BXGT010630 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 5305 reviewed Kinase
P48729 BXGT010655 Casein kinase I isoform alpha 1452 reviewed Kinase
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial 3418 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49792 BXGT010743 E3 SUMO-protein ligase RanBP2 5903 reviewed Enzyme modulator
P49840 BXGT010749 Glycogen synthase kinase-3 alpha 2931 reviewed Kinase
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P49913 BXGT010761 Cathelicidin antimicrobial peptide 820 reviewed
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P50281 BXGT010788 Matrix metalloproteinase-14 4323 reviewed Enzyme
P50416 BXGT010797 Carnitine O-palmitoyltransferase 1, liver isoform 1374 reviewed Enzyme
P50479 BXGT010804 PDZ and LIM domain protein 4 8572 reviewed Cellular structure
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P51580 BXGT010864 Thiopurine S-methyltransferase 7172 reviewed
P51617 BXGT010868 Interleukin-1 receptor-associated kinase 1 3654 reviewed Kinase
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P51878 BXGT010902 Caspase-5 838 reviewed Enzyme
P51946 BXGT010907 Cyclin-H 902 reviewed Enzyme modulator
P52333 BXGT010928 Tyrosine-protein kinase JAK3 3718 reviewed Kinase
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P54132 BXGT011032 Bloom syndrome protein 641 reviewed
P54136 BXGT011033 Arginine--tRNA ligase, cytoplasmic 5917 reviewed
P54802 BXGT011081 Alpha-N-acetylglucosaminidase 4669 reviewed
P55040 BXGT011099 GTP-binding protein GEM 2669 reviewed
P55055 BXGT011101 Oxysterols receptor LXR-beta 7376 reviewed Nuclear receptor
P55157 BXGT011108 Microsomal triglyceride transfer protein large subunit 4547 reviewed Transporter
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61011 BXGT011346 Signal recognition particle 54 kDa protein 6729 reviewed Nucleic acid binding
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61088 BXGT011358 Ubiquitin-conjugating enzyme E2 N 7334 reviewed
P61224 BXGT011370 Ras-related protein Rap-1b 5908 reviewed Enzyme modulator
P61978 BXGT011399 Heterogeneous nuclear ribonucleoprotein K 3190 reviewed Enzyme
P62258 BXGT011415 14-3-3 protein epsilon 7531 reviewed Chaperone
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P62993 BXGT011480 Growth factor receptor-bound protein 2 2885 reviewed
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P63279 BXGT011514 SUMO-conjugating enzyme UBC9 7329 reviewed
P69891 BXGT011646 Hemoglobin subunit gamma-1 3047 reviewed
P69892 BXGT011647 Hemoglobin subunit gamma-2 3048 reviewed
P69905 BXGT011649 Hemoglobin subunit alpha 3040 reviewed
P78358 BXGT011838 Cancer/testis antigen 1 246100 reviewed
P78504 BXGT011844 Protein jagged-1 182 reviewed
P78556 BXGT011849 C-C motif chemokine 20 6364 reviewed Signaling
P80404 BXGT011907 4-aminobutyrate aminotransferase, mitochondrial 18 reviewed Enzyme
P81172 BXGT011935 Hepcidin 57817 reviewed
P98170 BXGT012231 E3 ubiquitin-protein ligase XIAP 331 reviewed Enzyme modulator
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01081 BXGT012566 Splicing factor U2AF 35 kDa subunit 7307 reviewed
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01118 BXGT012570 Sodium channel protein type 7 subunit alpha 6332 reviewed Ion channel
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q01538 BXGT012597 Myelin transcription factor 1 4661 reviewed Transcription factor
Q01650 BXGT012603 Large neutral amino acids transporter small subunit 1 8140 reviewed Transporter
Q02083 BXGT012633 N-acylethanolamine-hydrolyzing acid amidase 27163 reviewed Enzyme
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q03468 BXGT012716 DNA excision repair protein ERCC-6 2074 reviewed
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q05397 BXGT012815 Focal adhesion kinase 1 5747 reviewed Kinase
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06187 BXGT012860 Tyrosine-protein kinase BTK 695 reviewed Kinase
Q06609 BXGT012884 DNA repair protein RAD51 homolog 1 5888 reviewed
Q07075 BXGT012917 Glutamyl aminopeptidase 2028 reviewed Enzyme
Q07108 BXGT012919 Early activation antigen CD69 969 reviewed
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q07954 BXGT012950 Prolow-density lipoprotein receptor-related protein 1 4035 reviewed
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 5530 reviewed
Q08722 BXGT013002 Leukocyte surface antigen CD47 961 reviewed
Q09472 BXGT013038 Histone acetyltransferase p300 2033 reviewed
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q12852 BXGT013272 Mitogen-activated protein kinase kinase kinase 12 7786 reviewed Kinase
Q12923 BXGT013281 Tyrosine-protein phosphatase non-receptor type 13 5783 reviewed
Q13043 BXGT013307 Serine/threonine-protein kinase 4 6789 reviewed Kinase
Q13105 BXGT013311 Zinc finger and BTB domain-containing protein 17 7709 reviewed
Q13153 BXGT013319 Serine/threonine-protein kinase PAK 1 5058 reviewed Kinase
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13206 BXGT013326 Probable ATP-dependent RNA helicase DDX10 1662 reviewed
Q13257 BXGT013333 Mitotic spindle assembly checkpoint protein MAD2A 4085 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13489 BXGT013364 Baculoviral IAP repeat-containing protein 3 330 reviewed Enzyme modulator
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q13546 BXGT013372 Receptor-interacting serine/threonine-protein kinase 1 8737 reviewed Kinase
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13569 BXGT013378 G/T mismatch-specific thymine DNA glycosylase 6996 reviewed
Q13951 BXGT013407 Core-binding factor subunit beta 865 reviewed
Q14032 BXGT013438 Bile acid-CoA:amino acid N-acyltransferase 570 reviewed
Q14103 BXGT013439 Heterogeneous nuclear ribonucleoprotein D0 3184 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 9817 reviewed
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase 7486 reviewed Enzyme
Q14469 BXGT013473 Transcription factor HES-1 3280 reviewed Transcription factor
Q14527 BXGT013479 Helicase-like transcription factor 6596 reviewed
Q14542 BXGT013482 Equilibrative nucleoside transporter 2 3177 reviewed Transporter
Q14624 BXGT013491 Inter-alpha-trypsin inhibitor heavy chain H4 3700 reviewed Enzyme modulator
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15022 BXGT013523 Polycomb protein SUZ12 23512 reviewed Nucleic acid binding
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 10682 reviewed Enzyme
Q15257 BXGT013554 Serine/threonine-protein phosphatase 2A activator 5524 reviewed Enzyme modulator
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q15582 BXGT013581 Transforming growth factor-beta-induced protein ig-h3 7045 reviewed Signaling
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15843 BXGT013608 NEDD8 4738 reviewed Nucleic acid binding
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16678 BXGT013656 Cytochrome P450 1B1 1545 reviewed Enzyme
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q6P2Q9 BXGT016446 Pre-mRNA-processing-splicing factor 8 10594 reviewed Nucleic acid binding
Q6PCD5 BXGT016464 E3 ubiquitin-protein ligase RFWD3 55159 reviewed Enzyme
Q6ZVN8 BXGT016641 Hemojuvelin 148738 reviewed
Q7LG56 BXGT016999 Ribonucleoside-diphosphate reductase subunit M2 B 50484 reviewed Enzyme
Q86YC2 BXGT017633 Partner and localizer of BRCA2 79728 reviewed
Q8IVW4 BXGT018350 Cyclin-dependent kinase-like 3 51265 reviewed Kinase
Q8IWS0 BXGT018356 PHD finger protein 6 84295 reviewed Nucleic acid binding
Q8IYD8 BXGT018367 Fanconi anemia group M protein 57697 reviewed Enzyme
Q8N159 BXGT018496 N-acetylglutamate synthase, mitochondrial 162417 reviewed
Q8N4E7 BXGT018511 Ferritin, mitochondrial 94033 reviewed Storage
Q8NB16 BXGT018535 Mixed lineage kinase domain-like protein 197259 reviewed Kinase
Q8NBL1 BXGT018539 Protein O-glucosyltransferase 1 56983 reviewed
Q8TCG1 BXGT018797 Protein CIP2A 57650 reviewed
Q8TDQ0 BXGT018810 Hepatitis A virus cellular receptor 2 84868 reviewed
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q92835 BXGT019382 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 3635 reviewed
Q92963 BXGT019401 GTP-binding protein Rit1 6016 reviewed Enzyme modulator
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96EP1 BXGT019651 E3 ubiquitin-protein ligase CHFR 55743 reviewed Enzyme
Q96GD4 BXGT019667 Aurora kinase B 9212 reviewed Kinase
Q96HC4 BXGT019671 PDZ and LIM domain protein 5 10611 reviewed Cellular structure
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96SW2 BXGT019743 Protein cereblon 51185 reviewed Enzyme
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 11315 reviewed Enzyme
Q99572 BXGT019935 P2X purinoceptor 7 5027 reviewed Ion channel
Q99640 BXGT019944 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 9088 reviewed Kinase
Q99808 BXGT019964 Equilibrative nucleoside transporter 1 2030 reviewed Transporter
Q99828 BXGT019967 Calcium and integrin-binding protein 1 10519 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q99873 BXGT019972 Protein arginine N-methyltransferase 1 3276 reviewed Epigenetic regulator
Q9BQ65 BXGT020107 U6 snRNA phosphodiesterase 79650 reviewed
Q9BXH1 BXGT020167 Bcl-2-binding component 3 27113 reviewed
Q9BY41 BXGT020180 Histone deacetylase 8 55869 reviewed Epigenetic regulator
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9BZ23 BXGT020194 Pantothenate kinase 2, mitochondrial 80025 reviewed Kinase
Q9BZ95 BXGT020196 Histone-lysine N-methyltransferase NSD3 54904 reviewed Epigenetic regulator
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H2X6 BXGT020458 Homeodomain-interacting protein kinase 2 28996 reviewed Kinase
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9HA47 BXGT020503 Uridine-cytidine kinase 1 83549 reviewed Kinase
Q9HCN6 BXGT020535 Platelet glycoprotein VI 51206 reviewed Receptor
Q9HD36 BXGT020541 Bcl-2-like protein 10 10017 reviewed Signaling
Q9NPD8 BXGT021152 Ubiquitin-conjugating enzyme E2 T 29089 reviewed
Q9NPI8 BXGT021161 Fanconi anemia group F protein 2188 reviewed
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NW38 BXGT021230 E3 ubiquitin-protein ligase FANCL 55120 reviewed Enzyme
Q9NWZ3 BXGT021239 Interleukin-1 receptor-associated kinase 4 51135 reviewed Kinase
Q9NY59 BXGT021251 Sphingomyelin phosphodiesterase 3 55512 reviewed
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9NYK1 BXGT021258 Toll-like receptor 7 51284 reviewed
Q9NYY3 BXGT021264 Serine/threonine-protein kinase PLK2 10769 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 11040 reviewed Kinase
Q9P212 BXGT021297 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 51196 reviewed Enzyme
Q9UBB5 BXGT021649 Methyl-CpG-binding domain protein 2 8932 reviewed Epigenetic regulator
Q9UH17 BXGT021691 DNA dC->dU-editing enzyme APOBEC-3B 9582 reviewed Enzyme
Q9UHD8 BXGT021698 Septin-9 10801 reviewed Enzyme modulator
Q9UI95 BXGT021714 Mitotic spindle assembly checkpoint protein MAD2B 10459 reviewed
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9UJV9 BXGT021731 Probable ATP-dependent RNA helicase DDX41 51428 reviewed
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9ULC5 BXGT021758 Long-chain-fatty-acid--CoA ligase 5 51703 reviewed Enzyme
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9UPN9 BXGT021799 E3 ubiquitin-protein ligase TRIM33 51592 reviewed
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 26013 reviewed Epigenetic regulator
Q9Y572 BXGT022289 Receptor-interacting serine/threonine-protein kinase 3 11035 reviewed Kinase
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
Q9Y6K9 BXGT022333 NF-kappa-B essential modulator 8517 reviewed Kinase
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
Q13029 BXGT022688 PR domain zinc finger protein 2 7799 reviewed
P43146 BXGT022852 Netrin receptor DCC 1630 reviewed
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
P25054 BXGT022961 Adenomatous polyposis coli protein 324 reviewed
Q01543 BXGT023137 Friend leukemia integration 1 transcription factor 2313 reviewed Transcription factor
Q9GZQ8 BXGT023414 Microtubule-associated proteins 1A/1B light chain 3B 81631 reviewed Cellular structure
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
Q59FF6 BXGT023693 Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant 2074 unreviewed
P20138 BXGT023857 Myeloid cell surface antigen CD33 945 reviewed Receptor
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
Q9HCK4 BXGT024280 Roundabout homolog 2 6092 reviewed
P16104 BXGT024571 Histone H2AX 3014 reviewed Nucleic acid binding
Q96L73 BXGT024676 Histone-lysine N-methyltransferase, H3 lysine-36 specific 64324 reviewed Epigenetic regulator
Q8NEZ4 BXGT024850 Histone-lysine N-methyltransferase 2C 58508 reviewed
Q12888 BXGT024878 TP53-binding protein 1 7158 reviewed Epigenetic regulator
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
Q9UNE7 BXGT025000 E3 ubiquitin-protein ligase CHIP 10273 reviewed
P98082 BXGT025047 Disabled homolog 2 1601 reviewed Signaling
P31358 BXGT025061 CAMPATH-1 antigen 1043 reviewed
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
Q9NRR4 BXGT025788 Ribonuclease 3 29102 reviewed Enzyme
Q86SQ9 BXGT025875 Dehydrodolichyl diphosphate synthase complex subunit DHDDS 79947 reviewed Enzyme
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
P62263 BXGT026033 40S ribosomal protein S14 6208 reviewed Nucleic acid binding
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease