Showing entry for Dual specificity protein phosphatase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010849
Protein NameDual specificity protein phosphatase 3
Uniport IdP51452
GeneDUSP3
Gene Id1845
DomainDSPc
Pfam PF00782  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0016311 dephosphorylation
Biological Process GO:0000188 inactivation of MAPK activity
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0050922 negative regulation of chemotaxis
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0046329 negative regulation of JNK cascade
Biological Process GO:0043409 negative regulation of MAPK cascade
Biological Process GO:0050868 negative regulation of T cell activation
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
Biological Process GO:0120183 positive regulation of focal adhesion disassembly
Biological Process GO:0045931 positive regulation of mitotic cell cycle
Biological Process GO:0051893 regulation of focal adhesion assembly
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0033549 MAP kinase phosphatase activity
molecular function GO:0016791 phosphatase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0008138 protein tyrosine/serine/threonine phosphatase activity
molecular function GO:1990782 protein tyrosine kinase binding
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0030971 receptor tyrosine kinase binding
cellular component GO:0005829 cytosol
cellular component GO:0001772 immunological synapse
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-198753 ERK/MAPK targets
R-HSA-202670 ERKs are inactivated
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-450294 MAP kinase activation
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0019326 BXGD001318 Ventral Hernia Pathological Conditions, Signs and Symptoms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0041296 BXGD002903 Tuberculosis Infections
C0151332 BXGD003415 Active tuberculosis Infections
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0205748 BXGD004117 Dysplastic Nevus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318973 BXGD012407 Staphylococcus aureus infection Infections
C3665593 BXGD019294 Melanocytic nevus of skin Neoplasms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001857 Caffeic acid 180.16
BXGC0001879 Chlorogenic acid 354.31
BXGC0003627 alpha-Linoleic acid 280.45
BXGC0005535 Licoagrone 742.81
BXGC0006193 Ellagic acid 302.19
BXGC0006326 Imperatorin 270.28
BXGC0006466 Oleanolic acid 456.71
BXGC0007171 Licoagroaurone 338.35
BXGC0011167 Moracin O 326.34
BXGC0011169 Moracin P 326.34
BXGC0013084 Kuwanon L 626.18
BXGC0016006 5-Methoxycanthinone 250.07
BXGC0017212 Glycybenzofuran 354.15
BXGC0020328 stigmasterol glucoside 574.42
BXGC0021441 Glisoflavone 368.13
BXGC0021929 Mulberrofuran C 580.17
BXGC0029191 5-hydroxy-2-hydroxymethylpyridine 125.05
BXGC0033435 Sanggenon G 694.24
BXGC0037549 Picrasidine L 250.07
BXGC0039611 Eurycomine E 280.08
BXGC0042336 7-Amino-4-Hydroxynaphthalene-2-Sulfonic Acid 239.03
BXGC0042410 10Z,13Z-Nonadecadienoic Acid 294.26
BXGC0046524 (R)-5-Ethyl-3-Hexadecanoyl-4-Methyl-5H-Furan-2-Oneo 368.26
BXGC0049247 dotriacontanoic acid 480.49
BXGC0049929 Isobavachalcone 324.14
BXGC0050191 Sanggenon C 708.22
BXGC0052172 12-octadecenoic acid 282.26
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein