Showing entry for Toll/interleukin-1 receptor domain-containing adapter protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011247
Protein NameToll/interleukin-1 receptor domain-containing adapter protein
Uniport IdP58753
GeneTIRAP
Gene Id114609
DomainTIR_2
Pfam PF13676  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
5. Organismal Systems 5.1 Immune system hsa04620 Toll-like receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
6. Human Diseases 6.1 Cancers: Overview hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070935 3'-UTR-mediated mRNA stabilization
Biological Process GO:0007250 activation of NF-kappaB-inducing kinase activity
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071221 cellular response to bacterial lipopeptide
Biological Process GO:0071223 cellular response to lipoteichoic acid
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0002755 MyD88-dependent toll-like receptor signaling pathway
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:0030890 positive regulation of B cell proliferation
Biological Process GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production
Biological Process GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0032735 positive regulation of interleukin-12 production
Biological Process GO:0032738 positive regulation of interleukin-15 production
Biological Process GO:0032755 positive regulation of interleukin-6 production
Biological Process GO:0032757 positive regulation of interleukin-8 production
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0090023 positive regulation of neutrophil chemotaxis
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0031334 positive regulation of protein-containing complex assembly
Biological Process GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
Biological Process GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
Biological Process GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0045088 regulation of innate immune response
Biological Process GO:0032648 regulation of interferon-beta production
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway
molecular function GO:0042802 identical protein binding
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
molecular function GO:0005080 protein kinase C binding
molecular function GO:0030674 protein-macromolecule adaptor activity
molecular function GO:0035663 Toll-like receptor 2 binding
molecular function GO:0035662 Toll-like receptor 4 binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0030139 endocytic vesicle
cellular component GO:0005886 plasma membrane
cellular component GO:0032587 ruffle membrane
Reactome
Pathway Id Pathway Name
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1280218 Adaptive Immune System
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-5260271 Diseases of Immune System
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000833 BXGD000014 Abscess Pathological Conditions, Signs and Symptoms; Infections
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0004623 BXGD000282 Bacterial Infections Infections
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007930 BXGD000502 Chagas Cardiomyopathy Infections; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011311 BXGD000714 Dengue Fever Infections
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019100 BXGD001283 Severe Dengue Infections
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023343 BXGD001635 Leprosy Infections
C0023462 BXGD001654 Acute Megakaryocytic Leukemias Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0024535 BXGD001785 Malaria, Falciparum Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0032269 BXGD002342 Pneumococcal Infections Infections
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0041296 BXGD002903 Tuberculosis Infections
C0041318 BXGD002909 Tuberculosis, Meningeal Infections; Nervous System Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085166 BXGD003136 Bacterial Vaginosis Female Urogenital Diseases and Pregnancy Complications; Infections
C0149725 BXGD003351 Lower respiratory tract infection Infections; Respiratory Tract Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0175697 BXGD004004 Van der Woude syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0242172 BXGD005138 Pelvic Inflammatory Disease Female Urogenital Diseases and Pregnancy Complications; Infections
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262380 BXGD005232 Asymptomatic bacteriuria Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0343804 BXGD007648 Chronic Chagas' disease Infections
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0744130 BXGD010088 Diabetic foot infection
C0877445 BXGD011350 Candidemia Pathological Conditions, Signs and Symptoms; Infections
C0919659 BXGD011434 Oropharyngeal candidiasis Infections
C0949690 BXGD011584 Spondylarthritis Musculoskeletal Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1609538 BXGD013444 Latent Tuberculosis Infections
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1834752 BXGD013995 MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding)
C1835828 BXGD014058 Invasive Pneumococcal Disease, Recurrent Isolated, 1 Infections; Immune System Diseases
C2169794 BXGD016933 Recurrent streptococcus pneumoniae infections
C2363741 BXGD017100 HIV-1 infection
C2747816 BXGD017577 Complicated malaria Infections
C3274515 BXGD018653 Severe Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C3714514 BXGD019409 Infection Infections
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4290046 BXGD022507 trachomatis
C4505163 BXGD022954 Food Addiction Mental Disorders; Behavior and Behavior Mechanisms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein