Showing entry for Acute Megakaryocytic Leukemias


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001654
Disease NameAcute Megakaryocytic Leukemias
Disease CUI IdC0023462
MeSH Codes C04  
Disease Class NameNeoplasms
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id HP:0002715   HP:0002664   HP:0001871  
Human Phenotype Ontology TermAbnormality of the immune system; Neoplasm; Abnormality of blood and blood-forming tissues
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O14965 BXGT004117 Aurora kinase A 6790 reviewed Kinase
O15392 BXGT004162 Baculoviral IAP repeat-containing protein 5 332 reviewed Enzyme modulator
O15439 BXGT004169 Multidrug resistance-associated protein 4 10257 reviewed Transporter
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01732 BXGT005782 T-cell surface glycoprotein CD8 alpha chain 925 reviewed
P02654 BXGT005911 Apolipoprotein C-I 341 reviewed
P02655 BXGT005912 Apolipoprotein C-II 344 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02743 BXGT005937 Serum amyloid P-component 325 reviewed
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P04049 BXGT006133 RAF proto-oncogene serine/threonine-protein kinase 5894 reviewed Kinase
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase 2597 reviewed Enzyme
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P07204 BXGT006567 Thrombomodulin 7056 reviewed
P07333 BXGT006602 Macrophage colony-stimulating factor 1 receptor 1436 reviewed Kinase
P07359 BXGT006612 Platelet glycoprotein Ib alpha chain 2811 reviewed Receptor
P07737 BXGT006663 Profilin-1 5216 reviewed
P08151 BXGT006731 Zinc finger protein GLI1 2735 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08514 BXGT006781 Integrin alpha-IIb 3674 reviewed
P08700 BXGT006816 Interleukin-3 3562 reviewed
P08887 BXGT006835 Interleukin-6 receptor subunit alpha 3570 reviewed Signaling
P0DN79 BXGT007511 Cystathionine beta-synthase-like protein 875 reviewed
P0DP23 BXGT007520 Calmodulin-1 808 reviewed
P0DP24 BXGT007521 Calmodulin-2 808 reviewed
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11308 BXGT007684 Transcriptional regulator ERG 2078 reviewed Transcription factor
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12724 BXGT007837 Eosinophil cationic protein 6037 reviewed
P13726 BXGT007950 Tissue factor 2152 reviewed Receptor
P15036 BXGT008073 Protein C-ets-2 2114 reviewed Transcription factor
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15531 BXGT008136 Nucleoside diphosphate kinase A 4830 reviewed Kinase
P16157 BXGT008203 Ankyrin-1 286 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P20701 BXGT008591 Integrin alpha-L 3683 reviewed
P22749 BXGT008803 Granulysin 10578 reviewed
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 6198 reviewed Kinase
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29074 BXGT009313 Tyrosine-protein phosphatase non-receptor type 4 5775 reviewed
P29375 BXGT009338 Lysine-specific demethylase 5A 5927 reviewed
P30085 BXGT009399 UMP-CMP kinase 51727 reviewed Kinase
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 7433 reviewed G-protein coupled receptor
P32320 BXGT009622 Cytidine deaminase 978 reviewed Enzyme
P35520 BXGT009842 Cystathionine beta-synthase 875 reviewed
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 2322 reviewed Kinase
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P52333 BXGT010928 Tyrosine-protein kinase JAK3 3718 reviewed Kinase
P58753 BXGT011247 Toll/interleukin-1 receptor domain-containing adapter protein 114609 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P62937 BXGT011471 Peptidyl-prolyl cis-trans isomerase A 5478 reviewed
P69891 BXGT011646 Hemoglobin subunit gamma-1 3047 reviewed
P69892 BXGT011647 Hemoglobin subunit gamma-2 3048 reviewed
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q06710 BXGT012887 Paired box protein Pax-8 7849 reviewed
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q12830 BXGT013268 Nucleosome-remodeling factor subunit BPTF 2186 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q15389 BXGT013564 Angiopoietin-1 284 reviewed Signaling
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q9NYA1 BXGT021254 Sphingosine kinase 1 8877 reviewed Kinase
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9Y6U3 BXGT022341 Adseverin 85477 reviewed Cellular structure
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
P29590 BXGT024350 Protein PML 5371 reviewed
P0DP25 BXGT024595 Calmodulin-3 808 reviewed
P20809 BXGT025043 Interleukin-11 3589 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease