Showing entry for Vesicle-associated membrane protein 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011487
Protein NameVesicle-associated membrane protein 2
Uniport IdP63027
GeneVAMP2
Gene Id6844
DomainSynaptobrevin
Pfam PF00957  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04130 SNARE interactions in vesicular transport
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.5 Excretory system hsa04962 Vasopressin-regulated water reabsorption
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0017156 calcium-ion regulated exocytosis
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0043308 eosinophil degranulation
Biological Process GO:0006887 exocytosis
Biological Process GO:0014047 glutamate secretion
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0061025 membrane fusion
Biological Process GO:0061024 membrane organization
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:0006892 post-Golgi vesicle-mediated transport
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0015031 protein transport
Biological Process GO:1902259 regulation of delayed rectifier potassium channel activity
Biological Process GO:0017157 regulation of exocytosis
Biological Process GO:0060627 regulation of vesicle-mediated transport
Biological Process GO:0009749 response to glucose
Biological Process GO:0035493 SNARE complex assembly
Biological Process GO:0048488 synaptic vesicle endocytosis
Biological Process GO:0016079 synaptic vesicle exocytosis
Biological Process GO:0006906 vesicle fusion
Biological Process GO:0016192 vesicle-mediated transport
molecular function GO:0048306 calcium-dependent protein binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0005543 phospholipid binding
molecular function GO:0043621 protein self-association
molecular function GO:0005484 SNAP receptor activity
molecular function GO:0000149 SNARE binding
molecular function GO:0017075 syntaxin-1 binding
molecular function GO:0019905 syntaxin binding
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0030665 clathrin-coated vesicle membrane
cellular component GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
cellular component GO:0060203 clathrin-sculpted glutamate transport vesicle membrane
cellular component GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0016020 membrane
cellular component GO:0043005 neuron projection
cellular component GO:0044306 neuron projection terminus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0030141 secretory granule
cellular component GO:0030667 secretory granule membrane
cellular component GO:0031201 SNARE complex
cellular component GO:0045202 synapse
cellular component GO:0008021 synaptic vesicle
cellular component GO:0030672 synaptic vesicle membrane
cellular component GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
cellular component GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
cellular component GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
cellular component GO:0005802 trans-Golgi network
cellular component GO:0031982 vesicle
cellular component GO:0042589 zymogen granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1430728 Metabolism
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-163685 Integration of energy metabolism
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-168799 Neurotoxicity of clostridium toxins
R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-199991 Membrane Trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-199992 trans-Golgi Network Vesicle Budding
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-264876 Insulin processing
R-HSA-2980736 Peptide hormone metabolism
R-HSA-392499 Metabolism of proteins
R-HSA-422356 Regulation of insulin secretion
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis
R-HSA-449147 Signaling by Interleukins
R-HSA-449836 Other interleukin signaling
R-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250982 Toxicity of tetanus toxin (TeNT)
R-HSA-5250989 Toxicity of botulinum toxin type G (BoNT/G)
R-HSA-5339562 Uptake and actions of bacterial toxins
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026837 BXGD001937 Muscle Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038271 BXGD002742 Stereotyped Behavior Behavior and Behavior Mechanisms
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0085620 BXGD003208 Flaccid paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0234398 BXGD004664 Visual Cortex Disorder Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1839839 BXGD014416 MAJOR AFFECTIVE DISORDER 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders
C1846135 BXGD014784 Autistic features
C1852197 BXGD015264 MAJOR AFFECTIVE DISORDER 1 Mental Disorders
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1970943 BXGD016852 MAJOR AFFECTIVE DISORDER 4 Mental Disorders
C1970945 BXGD016853 MAJOR AFFECTIVE DISORDER 6 Mental Disorders
C2700438 BXGD017469 MAJOR AFFECTIVE DISORDER 7 Mental Disorders
C2700439 BXGD017470 MAJOR AFFECTIVE DISORDER 8 Mental Disorders
C2700440 BXGD017471 MAJOR AFFECTIVE DISORDER 9 Mental Disorders
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4225275 BXGD022206 MENTAL RETARDATION, AUTOSOMAL DOMINANT 40
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0013764 D-Cysteine 121.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein