adisease

Showing entry for Muscle Rigidity

General Disease Information
BXGD Id	BXGD001937
Disease Name	Muscle Rigidity
Disease CUI Id	C0026837
MeSH Codes	C23 C05 C10
Disease Class Name	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
Semantic Type	Sign or Symptom
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00555	BXGT003936	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	773	reviewed	Ion channel
O14936	BXGT004114	Peripheral plasma membrane protein CASK	8573	reviewed	Kinase
O14980	BXGT004119	Exportin-1	7514	reviewed	Receptor
O15399	BXGT004164	Glutamate receptor ionotropic, NMDA 2D	2906	reviewed	Ion channel
O15455	BXGT004171	Toll-like receptor 3	7098	reviewed	Receptor
O15553	BXGT004181	Pyrin	4210	reviewed
O43464	BXGT004595	Serine protease HTRA2, mitochondrial	27429	reviewed
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O60741	BXGT004897	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	348980	reviewed
O75116	BXGT005100	Rho-associated protein kinase 2	9475	reviewed	Kinase
O75390	BXGT005123	Citrate synthase, mitochondrial	1431	reviewed	Enzyme
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
P00326	BXGT005499	Alcohol dehydrogenase 1C	126	reviewed	Enzyme
P00338	BXGT005504	L-lactate dehydrogenase A chain	3939	reviewed	Enzyme
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00709	BXGT005621	Alpha-lactalbumin	3906	reviewed
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P00918	BXGT005690	Carbonic anhydrase 2	760	reviewed
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01308	BXGT005749	Insulin	3630	reviewed
P02511	BXGT005885	Alpha-crystallin B chain	1410	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02671	BXGT005914	Fibrinogen alpha chain	2243	reviewed
P02675	BXGT005916	Fibrinogen beta chain	2244	reviewed	Signaling
P02679	BXGT005918	Fibrinogen gamma chain	2266	reviewed	Signaling
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02792	BXGT005966	Ferritin light chain	2512	reviewed	Storage
P04062	BXGT006140	Lysosomal acid glucosylceramidase	2629	reviewed
P04156	BXGT006156	Major prion protein	5621	reviewed
P04350	BXGT006193	Tubulin beta-4A chain	10382	reviewed	Cellular structure
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05106	BXGT006315	Integrin beta-3	3690	reviewed	Receptor
P05129	BXGT006322	Protein kinase C gamma type	5582	reviewed	Kinase
P05556	BXGT006368	Integrin beta-1	3688	reviewed	Receptor
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P07339	BXGT006604	Cathepsin D	1509	reviewed	Enzyme
P07478	BXGT006630	Trypsin-2	5645	reviewed	Enzyme
P08195	BXGT006745	4F2 cell-surface antigen heavy chain	6520	reviewed	Transporter
P08670	BXGT006810	Vimentin	7431	reviewed
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09936	BXGT006943	Ubiquitin carboxyl-terminal hydrolase isozyme L1	7345	reviewed	Enzyme
P10070	BXGT007534	Zinc finger protein GLI2	2736	reviewed
P10114	BXGT007539	Ras-related protein Rap-2a	5911	reviewed	Enzyme modulator
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P11309	BXGT007685	Serine/threonine-protein kinase pim-1	5292	reviewed	Kinase
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P16389	BXGT008221	Potassium voltage-gated channel subfamily A member 2	3737	reviewed	Ion channel
P16671	BXGT008255	Platelet glycoprotein 4	948	reviewed	Receptor
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17655	BXGT008325	Calpain-2 catalytic subunit	824	reviewed	Enzyme
P18031	BXGT008369	Tyrosine-protein phosphatase non-receptor type 1	5770	reviewed
P18206	BXGT008389	Vinculin	7414	reviewed
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	2566	reviewed	Ion channel
P19429	BXGT008479	Troponin I, cardiac muscle	7137	reviewed	Cellular structure
P21817	BXGT008693	Ryanodine receptor 1	6261	reviewed	Ion channel
P23415	BXGT008864	Glycine receptor subunit alpha-1	2741	reviewed	Ion channel
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28335	BXGT009255	5-hydroxytryptamine receptor 2C	3358	reviewed	G-protein coupled receptor
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30793	BXGT009466	GTP cyclohydrolase 1	2643	reviewed	Enzyme
P30825	BXGT009469	High affinity cationic amino acid transporter 1	6541	reviewed	Transporter
P32322	BXGT009624	Pyrroline-5-carboxylate reductase 1, mitochondrial	5831	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35270	BXGT009807	Sepiapterin reductase	6697	reviewed
P35499	BXGT009839	Sodium channel protein type 4 subunit alpha	6329	reviewed	Ion channel
P36956	BXGT009947	Sterol regulatory element-binding protein 1	6720	reviewed
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P39687	BXGT010131	Acidic leucine-rich nuclear phosphoprotein 32 family member A	8125	reviewed	Enzyme modulator
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42858	BXGT010341	Huntingtin	3064	reviewed
P43004	BXGT010348	Excitatory amino acid transporter 2	6506	reviewed	Transporter
P43354	BXGT010381	Nuclear receptor subfamily 4 group A member 2	4929	reviewed	Nuclear receptor
P43652	BXGT010405	Afamin	173	reviewed	Transporter
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46937	BXGT010554	Transcriptional coactivator YAP1	10413	reviewed	Enzyme modulator
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	2561	reviewed	Ion channel
P48167	BXGT010621	Glycine receptor subunit beta	2743	reviewed	Ion channel
P49448	BXGT010709	Glutamate dehydrogenase 2, mitochondrial	2747	reviewed	Enzyme
P49588	BXGT010713	Alanine--tRNA ligase, cytoplasmic	16	reviewed	Nucleic acid binding
P49768	BXGT010740	Presenilin-1	5663	reviewed	Enzyme
P49792	BXGT010743	E3 SUMO-protein ligase RanBP2	5903	reviewed	Enzyme modulator
P50453	BXGT010799	Serpin B9	5272	reviewed	Enzyme modulator
P52732	BXGT010948	Kinesin-like protein KIF11	3832	reviewed	Cellular structure
P54098	BXGT011030	DNA polymerase subunit gamma-1	5428	reviewed	Enzyme
P55265	BXGT011117	Double-stranded RNA-specific adenosine deaminase	103	reviewed	Enzyme
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60953	BXGT011342	Cell division control protein 42 homolog	998	reviewed	Enzyme modulator
P61626	BXGT011382	Lysozyme C	4069	reviewed
P61981	BXGT011400	14-3-3 protein gamma	7532	reviewed	Chaperone
P62258	BXGT011415	14-3-3 protein epsilon	7531	reviewed	Chaperone
P63027	BXGT011487	Vesicle-associated membrane protein 2	6844	reviewed
Q00610	BXGT012539	Clathrin heavy chain 1	1213	reviewed	Transporter
Q00975	BXGT012558	Voltage-dependent N-type calcium channel subunit alpha-1B	774	reviewed	Ion channel
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q03393	BXGT012711	6-pyruvoyl tetrahydrobiopterin synthase	5805	reviewed
Q04637	BXGT012771	Eukaryotic translation initiation factor 4 gamma 1	1981	reviewed	Nucleic acid binding
Q05193	BXGT012810	Dynamin-1	1759	reviewed	Enzyme modulator
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q05397	BXGT012815	Focal adhesion kinase 1	5747	reviewed	Kinase
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q06787	BXGT012890	Synaptic functional regulator FMR1	2332	reviewed	Nucleic acid binding
Q08209	BXGT012968	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	5530	reviewed
Q09470	BXGT013037	Potassium voltage-gated channel subfamily A member 1	3736	reviewed	Ion channel
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q13309	BXGT013338	S-phase kinase-associated protein 2	6502	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13586	BXGT013380	Stromal interaction molecule 1	6786	reviewed
Q14203	BXGT013455	Dynactin subunit 1	1639	reviewed	Chaperone
Q14721	BXGT013502	Potassium voltage-gated channel subfamily B member 1	3745	reviewed	Ion channel
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15392	BXGT013566	Delta(24)-sterol reductase	1718	reviewed	Enzyme
Q16620	BXGT013645	BDNF/NT-3 growth factors receptor	4915	reviewed	Kinase
Q16658	BXGT013651	Fascin	6624	reviewed	Cellular structure
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q5S007	BXGT015650	Leucine-rich repeat serine/threonine-protein kinase 2	120892	reviewed	Kinase
Q5VT25	BXGT015887	Serine/threonine-protein kinase MRCK alpha	8476	reviewed	Kinase
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q6N021	BXGT016378	Methylcytosine dioxygenase TET2	54790	reviewed
Q7L3T8	BXGT016994	Probable proline--tRNA ligase, mitochondrial	25973	reviewed	Enzyme
Q86V24	BXGT017615	Adiponectin receptor protein 2	79602	reviewed	Receptor
Q8WXF7	BXGT019011	Atlastin-1	51062	reviewed	Enzyme modulator
Q92743	BXGT019368	Serine protease HTRA1	5654	reviewed	Enzyme
Q96QK1	BXGT019720	Vacuolar protein sorting-associated protein 35	55737	reviewed	Transporter
Q99497	BXGT019926	Protein/nucleic acid deglycase DJ-1	11315	reviewed	Enzyme
Q99700	BXGT019949	Ataxin-2	6311	reviewed	Nucleic acid binding
Q9BXM7	BXGT020172	Serine/threonine-protein kinase PINK1, mitochondrial	65018	reviewed	Kinase
Q9BZ23	BXGT020194	Pantothenate kinase 2, mitochondrial	80025	reviewed	Kinase
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZZ9	BXGT020430	Ubiquitin-like modifier-activating enzyme 5	79876	reviewed	Enzyme
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NQX3	BXGT021172	Gephyrin	10243	reviewed
Q9NY46	BXGT021248	Sodium channel protein type 3 subunit alpha	6328	reviewed	Ion channel
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UQD0	BXGT021811	Sodium channel protein type 8 subunit alpha	6334	reviewed	Ion channel
Q9Y263	BXGT022220	Phospholipase A-2-activating protein	9373	reviewed	Enzyme modulator
Q9Y3I1	BXGT022260	F-box only protein 7	25793	reviewed
Q9Y4I1	BXGT022278	Unconventional myosin-Va	4644	reviewed	Cellular structure
P35523	BXGT023831	Chloride channel protein 1	1180	reviewed	Ion channel
Q9H5Q4	BXGT023970	Dimethyladenosine transferase 2, mitochondrial	64216	reviewed
Q9UNE7	BXGT025000	E3 ubiquitin-protein ligase CHIP	10273	reviewed
Q9Y4W6	BXGT025025	AFG3-like protein 2	10939	reviewed	Enzyme
Q8IZA0	BXGT025026	Dyslexia-associated protein KIAA0319-like protein	79932	reviewed
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
P35251	BXGT025853	Replication factor C subunit 1	5981	reviewed
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
Q96JB6	BXGT026118	Lysyl oxidase homolog 4	84171	reviewed
Q8WXI2	BXGT026145	Connector enhancer of kinase suppressor of ras 2	22866	reviewed
V9HWB9	BXGT026149	L-lactate dehydrogenase	3939	unreviewed
P09471	BXGT026153	Guanine nucleotide-binding protein G(o) subunit alpha	2775	reviewed	Enzyme modulator

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}