Showing entry for G/T mismatch-specific thymine DNA glycosylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013378
Protein NameG/T mismatch-specific thymine DNA glycosylase
Uniport IdQ13569
GeneTDG
Gene Id6996
DomainUDG
Pfam PF03167  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03410 Base excision repair
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006284 base-excision repair
Biological Process GO:0006285 base-excision repair, AP site formation
Biological Process GO:0006325 chromatin organization
Biological Process GO:0045008 depyrimidination
Biological Process GO:0080111 DNA demethylation
Biological Process GO:0006298 mismatch repair
Biological Process GO:0035562 negative regulation of chromatin binding
Biological Process GO:0032091 negative regulation of protein binding
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0035511 oxidative DNA demethylation
Biological Process GO:1902544 regulation of DNA N-glycosylase activity
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0040029 regulation of gene expression, epigenetic
molecular function GO:0005524 ATP binding
molecular function GO:0031404 chloride ion binding
molecular function GO:0003684 damaged DNA binding
molecular function GO:0003677 DNA binding
molecular function GO:0019104 DNA N-glycosylase activity
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity
molecular function GO:0000287 magnesium ion binding
molecular function GO:0030983 mismatched DNA binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0005080 protein kinase C binding
molecular function GO:0043621 protein self-association
molecular function GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity
molecular function GO:0031402 sodium ion binding
molecular function GO:0032183 SUMO binding
molecular function GO:0003712 transcription coregulator activity
molecular function GO:0008134 transcription factor binding
molecular function GO:0004844 uracil DNA N-glycosylase activity
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0016605 PML body
Reactome
Pathway Id Pathway Name
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329 Cleavage of the damaged pyrimidine
R-HSA-110357 Displacement of DNA glycosylase by APEX1
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-2990846 SUMOylation
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-392499 Metabolism of proteins
R-HSA-5221030 TET1,2,3 and TDG demethylate DNA
R-HSA-597592 Post-translational protein modification
R-HSA-73884 Base Excision Repair
R-HSA-73894 DNA Repair
R-HSA-73928 Depyrimidination
R-HSA-73929 Base-Excision Repair, AP Site Formation
R-HSA-73933 Resolution of Abasic Sites (AP sites)
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001857 BXGD000085 AIDS related complex Infections; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0014474 BXGD000917 Ependymoma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0043346 BXGD003043 Xeroderma Pigmentosum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278874 BXGD006605 Adult Ependymoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740345 BXGD009979 Germ Cell Cancer Neoplasms
C0796611 BXGD010835 Newly Diagnosed Childhood Ependymoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1851584 BXGD015221 Childhood Ependymoma Neoplasms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein