Showing entry for Sodium/potassium-transporting ATPase subunit alpha-4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013394
Protein NameSodium/potassium-transporting ATPase subunit alpha-4
Uniport IdQ13733
GeneATP1A4
Gene Id480
DomainCation_ATPase; Cation_ATPase_C; Cation_ATPase_N; E1-E2_ATPase
Pfam PF00689   PF00690  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0030007 cellular potassium ion homeostasis
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0009566 fertilization
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006811 ion transport
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0030641 regulation of cellular pH
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0035725 sodium ion transmembrane transport
Biological Process GO:0006814 sodium ion transport
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0150104 transport across blood-brain barrier
molecular function GO:0019829 ATPase-coupled cation transmembrane transporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0019900 kinase binding
molecular function GO:0046872 metal ion binding
molecular function GO:0005391 sodium:potassium-exchanging ATPase activity
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0045121 membrane raft
cellular component GO:0097733 photoreceptor cell cilium
cellular component GO:0005886 plasma membrane
cellular component GO:0120200 rod photoreceptor outer segment
cellular component GO:0005890 sodium:potassium-exchanging ATPase complex
cellular component GO:0097225 sperm midpiece
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-5663205 Infectious disease
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003165 BXGD000186 Anthracosis Respiratory Tract Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0036631 BXGD002626 Seminoma Neoplasms
C0338484 BXGD007188 Familial Hemiplegic Migraine Nervous System Diseases
C0859918 BXGD011204 Non-seminoma testicular cancer
C1832884 BXGD013880 Hemiplegic migraine, familial type 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003690 Glucokinin 764.94
BXGC0015208 Getiacaulein 288.06
BXGC0020220 panaxatriol 476.39
BXGC0022544 Digoxin 780.43
BXGC0023461 methylswertianin 288.06
BXGC0025733 1,3,5,6-Tetrahydroxyxanthen-9-One 260.03
BXGC0036400 1,3,5-Trihydroxyxanthen-9-One 244.04
BXGC0039507 Digitoxigenin 374.25
BXGC0044158 3,4,5-Trihydroxyxanthen-9-One 244.04
BXGC0048644 1,2,3,7-Tetramethoxyxanthone 316.09
BXGC0050699 \N 260.03
BXGC0051524 Ouabain 584.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein